Salivary Ammonia and its Relation to Dental Caries

Youngburg, Guy E.

doi:10.1177/00220345350150050301

Cited by 13 publications

(1 citation statement)

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“…They suggested that ammonia acted by reducing plaque forma tion. However, several other investigations were unable to substantiate this relationship between caries susceptibility and salivary ammonia concentration [White and Bunt ing, 1935;Youngburg, 1936;Karshan, 1936], Kleinberg and Jenkins [1964] found in vivo plaque pH values to be higher than sal ivary pH values and hypothesized that this was the result of plaque bacterial ureases converting salivary urea to ammonia. Evi dence supporting this theory was provided by Hassell [1972] who showed in vivo drops in oral fluid and interdental plaque pH after applying urease inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Effect of Topical Application of Urea Peroxide on Caries Incidence and Plaque Accumulation in Rats

Firestone¹,

Schmid²,

Mühlemann³

1982

Caries Res

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100 μl of 10.00/o aqueous solutions of the test substances were applied topically 3 times daily to molar teeth in 23-day-old CARA rats previously inoculated with Streptococcus mutans OMZ 176 and Actinomyces viscosus Ny-1 and receiving a highly cariogenic diet (56% sucrose) and tap water ad libitum. The test treatments were: (1) control H₂O, (2) hydrogen peroxide, (3) urea, (4) urea peroxide, (5) sodium percarbonate, and (6) sodium bicarbonate. Solutions were prepared daily. Urea peroxide and hydrogen peroxide were both highly effective in reducing plaque accumulation and caries incidence compared to the water control (p_F < 0.001). Sodium percarbonate was less effective. Urea and sodium bicarbonate were ineffective. The effectiveness of the agents in rats was thus related to their ability to release active oxygen rather than to their in vivo or in vitro ability to neutralize plaque acid.

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Section: Introductionmentioning

confidence: 99%