Salivary alpha amylase activity in migraine patients

Buğdaycı, Güler; Yıldız, Serpil; Altunrende, Burcu; Yıldız, Nebil; Alkoy, Seval

doi:10.1016/j.autneu.2010.01.011

Cited by 20 publications

(26 citation statements)

References 41 publications

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“…Bugdayci et al showed that in patients with migraine pain the level of salivary alpha amylase was elevated. Limited studies have been performed to evaluate the level of salivary alpha amylase in men and women 15. However, Enberg et al and Dezan et al, in contrast to the results of the present study, found no difference between the salivary alpha amylase activity by gender 22,23.…”

Section: Discussioncontrasting

confidence: 92%

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The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis

et al. 2013

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ObjectivesAssessment of dental pain severity is very challenging in dentistry. Previous studies have suggested that elevated salivary alpha amylase may contribute to increased physical stresses. There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. The aim of this study was to evaluate the relationship between pain severity and salivary alpha amylase levels in patients with symptomatic irreversible pulpitis.Materials and MethodsThirty-six patients (20 females and 16 males) with severe tooth pain due to symptomatic irreversible pulpitis were selected. The visual analogue scale (VAS) score was used to assess the pain severity in each patient. Unstimulated whole saliva was collected, and the level of alpha amylase activity was assessed by the spectrophotometric method. Statistical analysis was performed using SPSS 13.ResultsThe level of alpha amylase was significantly increased in the saliva in association with pain severity assessed by VAS. The salivary alpha amylase was also elevated with increased age and in males.ConclusionsThere was a significant correlation between the VAS pain scale and salivary alpha amylase level, which indicates this biomarker may be a good index for the objective assessment of pain intensity.

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Section: Discussioncontrasting

confidence: 92%

“…Similarly to previous studies,8,15 the results of this study showed that the level of salivary alpha amylase was proportional to the level of pain reported by patients. Alpha amylase activity differed between male and female participants.…”

Section: Discussionsupporting

confidence: 87%

The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis

et al. 2013

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“…Numerous studies have suggested sAA as a potential marker for sympatho-adrenal medullary activity [32][33][34]. There is also evidence that sAA concentrations are predictive of plasma catecholamine levels [35] and furthermore can be used as a valid indicator for measuring stress [33,36,37]. SAA significantly separated patients from controls and further distinguished between subclasses of TMD myalgia in our study sample.…”

Section: Discussionsupporting

confidence: 58%

Protein Signature in Saliva of Temporomandibular Disorders Myalgia

Jasim

Ernberg

Carlsson

et al. 2020

IJMS

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In the last years, several attempts have been made to study specific biological markers of temporomandibular disorders (TMD). So far, no laboratory tests have been appropriately validated for the diagnosis and prognosis of these disorders. This study aimed to investigate the proteomic profile of the whole stimulated saliva of TMD myalgia patients in order to evaluate potential diagnostic and/or prognostic salivary candidate proteins which could be useful for the management of TMD. Twenty patients diagnosed with TMD myalgia according to the validated Diagnostic Criteria for TMD (DC/TMD) and 20 matched healthy pain-free controls were enrolled. Saliva samples were collected in the morning. Comparative proteomic analysis was performed with two-dimensional gel electrophoresis followed by identification with liquid chromatography-tandem mass spectrometry. Statistical analysis of the quantitative proteomics data revealed that 20 proteins were significantly altered in patients compared to controls. Among these proteins, 12 showed significantly increased levels, and 8 showed significantly decreased levels in patients with TMD myalgia compared to controls. The identified proteins are involved in metabolic processes, immune response, and stress response. This proteomic study shows that the salivary protein profile can discriminate patients with TMD myalgia from healthy subjects, but the protein signature has no correlation with the clinical features of TMD myalgia. Additional studies are needed to validate our observations in additional sample sets and to continue assessing the utility of saliva as a suitable sample for studying processes related to TMD myalgia.

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“…In a clinical study investigating sympathetic activity in different phases of migraine, sympathetic hypofunction was detected during the attack phase, and sympathetic hyperfunction was detected during the postattack phase (Yildiz et al, 2008). In a later study, measurements of salivary amylase levels were shown to support these results (Bugdayci et al, 2010). However, these results have been contradicted by another experimental study.…”

Section: Discussionmentioning

confidence: 97%

Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

Kılınç

Fırat

Töre

et al. 2014

Journal of Neuroscience Research

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Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c-Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague-Dawley male rats with body weights of 200-250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c-Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P < 0.001). VIP decreased the number of mast cells in both sides of the dura mater in sympathectomized rats. VIP also decreased c-Fos expression in the ipsilateral trigeminal nucleus of sympathectomized rats (P < 0.001). In the context of an experimental superior cervical ganglionectomy model of migraine, VIP is an efficient modulator of neurogenic inflammation of the dura.

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Salivary alpha amylase activity in migraine patients

Cited by 20 publications

References 41 publications

The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis

The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis

Protein Signature in Saliva of Temporomandibular Disorders Myalgia

Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

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