Salivagram After Gland Injection of Botulinum Neurotoxin A in Patients With Cerebral Infarction and Cerebral Palsy

Park, Hea-Woon; Lee, Won-Yub; Park, Gi-Young; Kwon, Dong Rak; Lee, Zeeihn; Cho, Yun-Woo; Ahn, Sungjin; Lee, Dong‐Kyu

doi:10.1016/j.pmrj.2011.12.008

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…In salivary aspiration, the swallowing reflex is known to be an important defense against airway infection resulting from the aspiration of misdirected oropharyngeal or gastric contents into the larynx and lower airway. [18] The impairment of this reflex has been shown to be directly associated with an increased risk of silent aspiration and pneumonia in previous studies. [19,20] Moreover, it has been demonstrated that aspiration of pharyngeal secretions easily occurs in normal adults during deep sleep, presumably due to depression of pharyngeal reflexes, including the swallowing reflex.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of dysphagic stroke patients with salivary aspiration

Park²

2019

Medicine

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The aim of this study was to evaluate the correlation between radionuclide salivagram findings and clinical characteristics in stroke patient with swallowing difficulty. In this study, dysphagic stroke patients who had undergone both a radionuclide salivagram and videofluoroscopic swallowing study (VFSS) were included retrospectively. To evaluate the correlations between clinical parameters and salivary aspiration, clinical parameters, such as stroke lesion, the degree of paralysis, sex, age, onset duration of stroke, the score of the Mini-Mental State Examination (MMSE), the score of the Global Deterioration Scale (GDS), the total score of the Modified Barthel Index (MBI), and each sub-score of the MBI were collected and analyzed. In the results of this study, the MMSE score was the only significant parameter for predicting positive findings in a salivagram in a multivariate logistic regression analysis in patients with supratentorial stroke. In patients with infratentorial stroke, however, the transfer sub-score of MBI was the only significant parameter for predicting positive findings in a salivagram in a multivariate logistic regression analysis. In conclusion, care should be taken to prevent salivary aspiration when the MMSE score is less than eight in patients with supratentorial stroke, and the transfer sub-score of MBI score is less than three in patients with infratentorial stroke.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of dysphagic stroke patients with salivary aspiration

Park²

2019

Medicine

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“…Общая средняя продолжительность лечебного эффекта составляет 87 дней и одинакова для обоих серотипов. Повторные инъекции не влияет на продолжительность эффекта [15,[26][27][28][29][30].…”

Section: методы лечения сиалореиunclassified

“…Некоторые авторы указывали на более тяжелые побочные эффекты: дисфагию [15,31,[34][35][36][37][38][39][40][41], дислокацию челюсти [15], затруднение при жевании [34,38]; удушье [36], аспирационную пневмонию [36,41,42], преходящий парез лицевого нерва [13], временную неловкость при ношении зубных протезов [43], слабость в мышцах шеи [41]. Некоторые из исследований касаются непосредственного применения БТ при сиалорее вследствие перенесенного инсульта [28,29,[44][45][46]. В частности, в одном из них инъекции БТ-B проводились в обе подчелюстные железы под ультразвуковым контролем [29].…”

Section: методы лечения сиалореиunclassified

“…Некоторые из исследований касаются непосредственного применения БТ при сиалорее вследствие перенесенного инсульта [28,29,[44][45][46]. В частности, в одном из них инъекции БТ-B проводились в обе подчелюстные железы под ультразвуковым контролем [29]. Выраженность слюнотечения оценивалась по индексу слюнотечения (Drooling quotient -DQ) и по шкале оценки слюнотечения (Drooling Impact Scale -DIS) на протяжении 16 нед после инъекции.…”

Section: методы лечения сиалореиunclassified

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Salivation after stroke

Zalyalova

2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Salivation after stroke (sialorrhea, hypersalivation, ptyalism) can be caused by the overproduction or a lack of utilization of saliva. Patients after stroke often have sialorrhea as a result of dysphagia. Neurogenic dysphagia in acute period after stroke occurs in 25-65% of patients. The mortality rate among people with post-stroke dysphagia and tube feeding ranges from 20 to 24%. Patients who suffering from profuse salivation have difficulties with articulation and swallowing, bad breath, irritation and maceration of perioral area, contamination of clothing and bed linen. Profuse salivation increases caregiver burden as well. Psychologically, profuse salivation leads to lower self-esteem and social isolation. Pulmonary aspiration is the most serious complication of sialorrhea. Injections of botulinum toxins in the large salivary glands and the m. cricopharyngeus are the most effective method of treatment.

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Sialorrhea in children with cerebral palsy

Dias¹,

Fernandes²,

Filho³

2016

Jornal de Pediatria

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The most effective treatment that addresses the cause of sialorrhea in children with cerebral palsy is training of sensory awareness and oral motor skills, performed by a speech therapist. Botulinum toxin injection and the use of anticholinergics have a transient effect and are adjuvant to speech therapy; they should be considered in cases of moderate to severe sialorrhea or respiratory complications. Atropine sulfate is inexpensive and appears to have good clinical response combined with good safety profile. The use of trihexyphenidyl for the treatment of sialorrhea can be considered in dyskinetic forms of cerebral palsy or in selected cases.

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Salivagram After Gland Injection of Botulinum Neurotoxin A in Patients With Cerebral Infarction and Cerebral Palsy

Cited by 6 publications

References 15 publications

Clinical characteristics of dysphagic stroke patients with salivary aspiration

Clinical characteristics of dysphagic stroke patients with salivary aspiration

Salivation after stroke

Sialorrhea in children with cerebral palsy

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