Saliva resistin as a screening marker of gestational diabetes mellitus

Gürlek, Beril; Çolak, Sabri

doi:10.1080/09513590.2020.1807504

Cited by 5 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It increases plasma glucose concentrations in this way and thus, decreases insulin sensitivity, which in turn has a role in the pathogenesis of GDM [ 56 ]. It has also been observed that its proinflammatory properties may contribute to a decrease in the number of pancreatic beta cells [ 89 ]. Moreover, resistin has a direct effect on the increase in reactive oxygen species (ROS) production and may induce oxidative stress.…”

Section: Biomoleculesmentioning

confidence: 99%

See 1 more Smart Citation

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

Niebrzydowska

Pilszyk

et al. 2021

IJMS

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.

show abstract

Section: Biomoleculesmentioning

confidence: 99%

“…Gürlek et al studied resistin levels in saliva and serum of pregnant women [ 89 ]. In both types of samples, they found higher resistin concentrations in women who later developed GDM compared to healthy controls.…”

Section: Biomoleculesmentioning

confidence: 99%

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

Niebrzydowska

Pilszyk

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…More recently, in 2020, Gürlek and Çolak[ 83 ] investigated the effectiveness of evaluating salivary resistin concentrations as a screening marker for gestational diabetes mellitus (GDM). Gestational diabetes mellitus is a type of diabetes that occurs during pregnancy with an incidence that varies from 1% to 25%[ 84 , 85 ].…”

Section: Salivary Resistin and Ir In Obese Individualsmentioning

confidence: 99%

“…Studies have also shown that the risk of GDM is far higher among overweight and obese pregnant women, especially those with central obesity[ 88 - 90 ]. Gürlek and Çolak[ 83 ] included 81 pregnant women in their study: 41 with newly diagnosed GDM and 40 with normal pregnancy without GDM. Fasting blood and unstimulated saliva samples were collected, and resistin was estimated using an enzyme-linked immunosorbent assay.…”

Section: Salivary Resistin and Ir In Obese Individualsmentioning

confidence: 99%

“…The study revealed that pregnant women with GDM had significantly higher pre-gestational BMI, BMI at the time of sampling, and salivary resistin concentrations as compared with the pregnant women without GDM. Hence their study provided evidence for the first time that resistin concentrations in saliva might be a useful screening marker for GDM[ 83 ].…”

Section: Salivary Resistin and Ir In Obese Individualsmentioning

confidence: 99%

See 1 more Smart Citation

Salivary resistin level and its association with insulin resistance in obese individuals

Abdalla¹

2021

WJD

View full text Add to dashboard Cite

The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance (IR) in high-risk groups, including overweight and obese individuals. The use of salivary biomarkers offers a promising alternative to serum collection because it is safer, more comfortable, and less painful to obtain saliva samples. As obesity is the foremost contributory factor in IR development, the adipocytokines such as leptin, adiponectin, resistin, and visfatin secreted from the adipose tissue have been studied as potential reliable biomarkers for IR. Measurement of salivary adipokines as predictors for IR has attracted widespread attention because of the strong correlation between their blood and salivary concentrations. One of the adipokines that is closely related to IR is resistin. However, there are conflicting findings on resistin’s potential role as an etiological link between obesity and IR and the reliability of measuring salivary resistin as a biomarker for IR. Hence this study reviewed the available evidence on the potential use of salivary resistin as a biomarker for IR in order to attempt to gain a better understanding of the role of resistin in the development of IR in obese individuals.

show abstract