Saliva: Its Role in Health and Disease

Herrera, Jorge; Lyons, M.F.; Johnson, Lawrence F.

doi:10.1097/00004836-198810000-00019

Cited by 101 publications

(37 citation statements)

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“…The component proteins produced and released into saliva by the salivary glands are grouped according to their functions: lubrication of the oral cavity (mucins, proline-rich proteins), remineralization (statherin, proline-rich proteins), digestion (amylase, lipase, proteases), antimicrobial activity (lysozyme, peroxidases, histatins), and mucosal integrity (water, mucins, growth factors) (1)(2)(3). Biologically active growth factors include epidermal growth factor (EGF) and nerve growth factor (NGF), both of which are synthesized and secreted by the granular convoluted tubule cells of the salivary glands (4,5).…”

mentioning

confidence: 99%

Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

Nagy

Nagashima²,

Cha³

et al. 2001

Diabetes

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Using the NOD mouse, a model for type 1 diabetes, we examined how reduced concentrations of epidermal growth factor (EGF) in the saliva, after onset of type 1 diabetes, affect oral wound healing. Diabetic NOD/LtJ mice on insulin therapy, prediabetic NOD/LtJ, and ageand sex-matched BALB/cJ mice were given a cutaneous tongue punch and allowed to undergo normal healing. With diabetes onset and a reduction in saliva-derived growth factor levels, the rate of tongue wound healing was reduced compared with nondiabetic NOD/LtJ and healthy BALB/cJ mice. Addition of exogenous EGF to the drinking water did not accelerate the rate of healing in BALB/cJ or prediabetic NOD/LtJ; however, diabetic NOD/LtJ mice exhibited accelerated wound healing similar to healthy mice. These results demonstrate that loss of growth factors from saliva is associated with profoundly reduced oral wound healing, suggesting that therapeutic treatment with topical delivery may be beneficial to patients with type 1 diabetes and oral wound complications.

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mentioning

confidence: 99%

Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

Nagy

Nagashima²,

Cha³

et al. 2001

Diabetes

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“…It is, however, collected simply and provides clinically relevant information. 26 Single gland saliva collection is more difficult and has a higher value in cases where the composition of saliva from an individual gland is to be studied, but this was not the subject of the present study.…”

Section: Discussionmentioning

confidence: 97%

Scintigraphic study of the major salivary glands in pediatric bone marrow transplant recipients

Bågesund

Richter²,

Ågren³

et al. 2000

Bone Marrow Transplant

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Summary:Total body irradiation (TBI) at bone marrow transplantation (BMT) is shown to cause salivary gland dysfunction in children. The aim of the investigation was to study the function of major salivary glands in long-term surviving children following treatment with TBI, using salivary gland scintigraphy (SGS). Thirteen patients (seven male, six female), who had received TBI before the age of 13 years and survived more than 4 years, participated in the study. A reference group of 10 patients (nine male, one female) was examined shortly before they were to undergo BMT. The mean age was 14.1 ± 4.1 years in the TBI-treated group and 12.8 ± 5.9 years in the reference group. Unstimulated and stimulated whole salivary secretion rates were measured for 15 and 5 min, respectively, before SGS was performed. The percentage of stimulated secretion was 44.7 ± 18.1% in the TBI-treated group compared to 58.4 ± 13.0% in the reference group (P = 0.0438). Slower reaccumulation after excretion was found in the TBItreated patients compared to the reference group (P = 0.0300). The function of the major salivary glands in long-term survivors treated with TBI at BMT before the age of 13 years was found to be diminished, as shown by the reduced trapping rate and reduced emptying capacity, compared to prior to BMT. Bone Marrow Transplantation (2000) 26, 775-779.

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“…The main functions of saliva are to lubricate the oral cavity, to facilitate swallowing, and to prevent demineralization of the teeth. It also allows carbohydrate digestion and regulates oral microbial flora by maintaining the oral pH and enzyme activity [75,76]. The daily total salivary secretion volume is in between 0.5 and 2.0 L. However, the volume of saliva constantly present in the mouth is around 1.1 ml, thus providing relatively low fluid volume available for drug release from delivery systems compared to the GIT.…”

Section: Challenges In Buccal Drug Delivery Developmentmentioning

confidence: 99%

Buccal Drug Delivery System : History and Recent Developments

Arun¹

2016

Asian J Pharm Clin Res

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Being an alternate method of systemic drug delivery, oral mucosal drug delivery proves to be advantageous over both injectable and enteral methods. Because of the mucosal surface usually being rich in blood supply, it enhances drug bioavailability, thereby enabling rapid drug transport to the systemic circulation. Moreover, in most cases, it avoids degradation by first-pass hepatic metabolism. The drug absorption takes place faster as it is in contact with the absorption surface. The drug delivery system helps the drug to remain at the same place of application longer for once or twice daily dosing. For some drugs, the alternate way of administration results in novel methods of action as opposed to the above-said procedure. The characteristics of the oral mucosa as well as physicochemical properties of the drug pose as a hindrance to the oral mucosal administration of some drugs. Commercial availability of drug is restricted, although most of the drugs are qualitatively assessed for oral transmucosal delivery. The clinical benefit produced by an oral transmucosal dosage form is good even though the production of this dosage form is expensive. Transmucosal products are the recent drug delivery strategies. Delivery through transmucosal products benefits the absorption 4 times than that of the skin. Considering the availability of products, only some drugs are used for oral transmucosal delivery. Hence, new drugs have to be processed and developed to meet the limited transmucosal drug delivery. The present paper intends to emphasize the importance of oral transmucosal drug delivery and also highlights on the latest advancement in the field.

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Saliva: Its Role in Health and Disease

Cited by 101 publications

References 0 publications

Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

Scintigraphic study of the major salivary glands in pediatric bone marrow transplant recipients

Buccal Drug Delivery System : History and Recent Developments

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