Saliva composition and caries development in asthmatic patients treated with β<sub>2</sub>‐adrenoceptor agonists: a 4‐year follow‐up study

Ryberg, Mats; Möller, Christian; Ericson, Thomas

doi:10.1111/j.1600-0722.1991.tb01887.x

Cited by 89 publications

(122 citation statements)

References 19 publications

(17 reference statements)

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“…However, only 42.4% of the asthma subjects used anti-asthma medications, indicating that the medication rather than the condition may play a role. Consistent with this hypothesis, a longitudinal study by Ryberg et al, [33] reported that chronic treatment with beta2-adrenoceptor agonists in asthmatics caused a decrease in salivary flow and an increase in caries incidence. Thomson et al, [24] also found a statistically significant increase in coronal caries among anti-asthma medication users.…”

Section: Introductionsupporting

confidence: 59%

Prevalence of Dental Carious Lesions with Different Classes of Medications

Singh¹

2015

GGM

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Background: Past research has produced conflicting results concerning the usage of medications and the associated oral health consequences. The authors examined non-cavitated and cavitated coronal and root carious lesions among subjects taking a variety of medications compared to those taking no medications to assess whether the effects of taking multiple medications had on carious lesion prevalence.Objective: The objective of this study was to assess how the different classes of medication adversely affected the oral cavity, specifically in the formation of dental carious lesions.Methods: A representative sample of 1028 volunteers aged 40-80 from the Greater Boston area, with at least 10 natural teeth were included in this study. After disqualifying subjects on medications with autoimmune conditions known to cause xerostomia, or a previous history of radiation to the head and neck area, 882 volunteers on medications known to cause salivary hypofunction and 146 volunteers taking no medications were enrolled. Non-cavitated and cavitated carious lesions were examined by a single calibrated dental examiner using visual and tactile methods. Major medication groups included psychiatric (N=258), single antihypertensive (N=180), multiple antihypertensive including cardiac medications (N=145), a combination of antihypertensive and psychiatric medications (N=85), anti-asthma medications (N=67), Non-Steroidal Anti-Inflammatory (NSAIDs) (N= 34) and all other medications (N=113).Results: Subjects on psychiatric medications had the highest number of total carious lesions (5.4±4.94) while those taking no medications had the least (2.6±2.92). Subjects on a combination of antihypertensive and psychiatric medications had the highest number of carious root surface lesions (1.18±4.06). Those subjects on anti-asthma medications exhibited the highest number of cavitated coronal surface lesions (1.41±2.06). Conclusion:This study found xerostomic medications vary in their deleterious effects on dental carious lesions. A combination of antihypertensive and psychiatric medications is the most detrimental, as evidenced by a higher prevalence of carious lesions in those participants taking them.Clinical significance: As usage of concomitant xerogenic medications is likely to continue to increase, educating clinicians and the general public about the effects on oral health is essential to limiting dental carious lesions by instituting appropriate preventive protocols. Keywords: Dental carious lesions; Medications; Side effectsCitation: Singh M, Papas AS, Papas AN, Barker ML, Biesbrock A (2015) [7,13,14,[21][22][23][24][25][26][27][28][29][30][31].Past research has produced conflicting results concerning a link between asthma medications and caries incidence. Meldrum et al., [32] found no significant differences in caries increment between asthma-free and asthma subjects. However, only 42.4% of the asthma subjects used anti-asthma medications, indicating that the medication rather than the condition may play a role. Consistent wi...

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Section: Introductionsupporting

confidence: 59%

Prevalence of Dental Carious Lesions with Different Classes of Medications

Singh¹

2015

GGM

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“…Published studies on oral health in adults with asthma are relatively few and present large variations in ages of the participants, asthma severity, duration, medication and sample size [10,11,[22][23][24]. One explanation for this may be the difficulty involved in recruiting well-controlled, homogeneous groups with long-term disease.…”

Section: Discussionmentioning

confidence: 97%

Oral health in young adults with long-term, controlled asthma

Stensson

Wendt

Koch³

et al. 2011

Acta Odontologica Scandinavica

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Objectives. The aim of the present investigation was to study oral health in young adults with long-term, controlled asthma. Material and methods. Twenty 18-to 24-year-olds with a mean duration (SD) of asthma disease of 13.5 (5.4) years and 20 matched healthy controls were included. A clinical examination was performed and the prevalence of caries, erosions, gingival inflammation, cervicular fluid, periodontal pockets and plaque formation rate, were registered. The salivary flow rate, numbers of mutans streptococci and lactobacilli in saliva were determined. Plaque pH was measured after a sucrose rinse up to 40 min at two approximal sites. The participants were interviewed regarding dietary and oral hygiene habits. Results. The mean (SD) DFS, including manifest and initial caries, was 8.6 (10.6) in the asthma group and 4.0 (5.2) in the control group (p = 0.09). Initial caries lesions were more common in the asthma group than in the control group, 6.0 (8.1) and 1.3 (2.0 (p = 0.02). The asthma group had more gingivitis (p = 0.01) and lower stimulated salivary rate than the controls (p = 0.01). The asthmatics had also a somewhat, but not statistically significant, lower initial pH value in plaque and more pronounced pH drop compared with the controls. In the asthma group, 65% reported frequent mouthbreathing compared with 10% in the controls (p = 0.01). No differences were found in tooth-brushing and dietary habits between the groups. Conclusions. Young adults with long-term, controlled asthma had more initial caries, more gingival inflammation and lower stimulated salivary secretion rate than individuals without asthma.

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“…Eloot et al [17] found that neither the length of the disease period in 3 to17-year-old children with asthma nor the medication or the severity of the asthma disease had a significant effect on the risk of developing caries or gingivitis. In studies by Ryberg et al [12,13], however, it was shown that asthmatic children who medicated with β 2 agonists had a decreased saliva secretion rate and increased levels of lactobacilli and mutans streptococci, in addition to more caries lesions, compared with healthy children. Mc Derra et al [8] found that 4-to 10-year-old children with asthma had more plaque, gingivitis and calculus compared with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors have reported a correlation between childhood asthma and dental caries in pre-school children [6][7][8][9][10][11][12][13], while others have found no such connection [14][15][16]. Eloot et al [17] found that neither the length of the disease period in 3 to17-year-old children with asthma nor the medication or the severity of the asthma disease had a significant effect on the risk of developing caries or gingivitis.…”

Section: Introductionmentioning

confidence: 99%

Oral health in preschool children with asthma

Stensson

Wendt

Koch³

et al. 2008

Int J Paed Dentistry

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Objective. The aim of the present study was to investigate oral health and its determinants in 3-and 6-year-old children with asthma. Methods and Subjects.Caries and gingivitis were examined in 127 asthmatic (all children with asthma in a selected area and born during a specific time period) and 117 matched, healthy control children.The parents were interviewed regarding various oral health-related factors.Results. The mean dfs (± standard deviation) in the 3-year-olds with asthma was 1.4 ± 3.2 compared with 0.5 ± 1.2 in the controls (P < 0.05). The corresponding figures for the 6-year-olds were 2.5 ± 3.9 and 1.8 ± 2.8. The 3-year-old asthmatic children had more gingival bleeding than healthy controls (P < 0.05). There were no significant differences in gingivitis in the 6-year-olds.Asthmatic children reported higher consumption of sugar-containing drinks and were more frequently mouthbreathers than healthy children (P < 0.05). In 3-year-old children with asthma and immigrant background, the mean dfs was higher compared with immigrant children in the control group (P < 0.01). Conclusion.The results indicate that pre-school children with asthma have higher caries prevalence than healthy children. The factors discriminating for caries in asthmatic children are higher intake of sugary drinks, mouthbreathing and immigrant background.

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Saliva composition and caries development in asthmatic patients treated with β₂‐adrenoceptor agonists: a 4‐year follow‐up study

Cited by 89 publications

References 19 publications

Prevalence of Dental Carious Lesions with Different Classes of Medications

Prevalence of Dental Carious Lesions with Different Classes of Medications

Oral health in young adults with long-term, controlled asthma

Oral health in preschool children with asthma

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Saliva composition and caries development in asthmatic patients treated with β2‐adrenoceptor agonists: a 4‐year follow‐up study

Cited by 89 publications

References 19 publications

Prevalence of Dental Carious Lesions with Different Classes of Medications

Prevalence of Dental Carious Lesions with Different Classes of Medications

Oral health in young adults with long-term, controlled asthma

Oral health in preschool children with asthma

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Product

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Saliva composition and caries development in asthmatic patients treated with β₂‐adrenoceptor agonists: a 4‐year follow‐up study