Saliva as a sampling source for the detection of leukemic fusion transcripts

Chen, Dongmei; Song, Najie; Ni, Runfang; Zhao, Jiangning; Hu, Jian; Lu, Quanyi; Li, Qingge

doi:10.1186/s12967-014-0321-z

Cited by 7 publications

(5 citation statements)

References 18 publications

(13 reference statements)

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“…Such associations might allow for the potential use of saliva to detect minimal residual disease in leukaemia. 53 Based on recent studies, it has been proposed that salivary trehalose, which could be detected by some cell-based extended gate ion-sensitive field-effect transistor biosensors, might provide a sensitive and direct way to screen for Alzheimer's disease. 54 Wilson's disease is a rare inherited disorder of copper metabolism and is characterized by hepatic, neurological and psychiatric symptoms.…”

Section: Diagnosis Of Systematic Diseases By Salivamentioning

confidence: 99%

Saliva in the diagnosis of diseases

et al. 2016

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Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.

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Section: Diagnosis Of Systematic Diseases By Salivamentioning

confidence: 99%

Saliva in the diagnosis of diseases

et al. 2016

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“…A genomic study by Chen et al [ 44 ] analysed 30 common fusion gene transcripts that are the hallmark of leukaemia (i.e., BCR - ABL among others) in the saliva samples of seven leukemic patients and 20 healthy individuals. The results showed concordance between the fusion genes detected in the saliva samples with those in the bone marrow.…”

Section: Systemic Cancer and Salivamentioning

confidence: 99%

Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity

Rapado‐González

Majem

Muinelo‐Romay

et al. 2016

IJMS

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Abstract:The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. Multiple molecules isolated in saliva have been proposed as cancer biomarkers for diagnosis, prognosis, drug monitoring and pharmacogenetic studies. In this review, we focus on the current status of the salivary diagnostic biomarkers for different cancers distant to the oral cavity, noting their potential use in the clinic and their applicability in personalising cancer therapies.

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“…(18). So saliva is termed as liquid biopsies that hold great clinical potential (17), as diagnostics tools of their noninvasive nature allows for quick, easy of accessibility (transport and storage), safe handling, economical, and repeat sampling sorts (19), that permit their utilizing in screening programs and for the close observing of treatment response and disease progression, letting for earlier intervention and dynamic treatment administration (17,20). Also it presents less risk of infection and accurate.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of salivary, serum, nitric oxide, and arginase in breast cancer

Yousif

Ismail

2023

Ital J Med

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Background: Breast cancer is the most commonly diagnosed cancer among females. A source of sampling for clinical diagnosis is saliva which has been utilized and it is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, utilizing saliva as a biomarker, specifically for early cancer diagnosis has attracted much research interest. Aim: To alter the sample collection from blood to saliva for some components such as nitric oxide (NO) and arginase, in order to detect an easy, earlier and noninvasive diagnostic test as biomarkers and prognostic tools in patients with breast cancer. Methods: A total of 73 female volunteers were participated in this study, 25 healthy volunteers compared with 48 patients with breast cancer in order to estimate and compare both salivary and blood level components such as NO and arginase. Results: The mean blood and salivary samples for both nitric oxide and arginase levels were significantly raised in patients with breast cancer when they compared with controls (p<0.001). Conclusions: In this study the changing of salivary levels of NO and arginase as compared with blood may be used as a non-invasive diagnostic tool alternative to serum testing component, which were significantly increased in patients with breast cancer in both blood and saliva and also, may be used as biomarkers and tumor progression tests in diagnosing of breast cancer.

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Saliva as a sampling source for the detection of leukemic fusion transcripts

Cited by 7 publications

References 18 publications

Saliva in the diagnosis of diseases

Saliva in the diagnosis of diseases

Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity

Clinical significance of salivary, serum, nitric oxide, and arginase in breast cancer

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