Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer

Kumar, Prabhat; Gupta, Shilpi; Das, Bhudev C.

doi:10.1016/j.tranon.2023.101827

Cited by 14 publications

(6 citation statements)

References 228 publications

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“…Data in the literature report a rare recurrence rate for HPV-related lesions (papilloma, warts, and condiloma) [ 45 , 46 , 47 ]. Likewise, a very low recurrence rate was found by our data: only 4.6% of HPV-positive lesions recurred, and on average, it happened within the first 12 months (50% of cases at 12 months, 33.3% at 6 months, and 16.7% at 16 months).…”

Section: Discussionmentioning

confidence: 99%

The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study

Rushiti,

Castellani,

Cerrato

et al. 2023

JCM

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Human papilloma virus (HPV) is known as the main cause of cervical cancer. Data also indicate its role in head–neck cancer, especially oropharyngeal cancer. The correlation between high-risk HPV and oral cancer is still controversial. HPV-related lesions of the oral cavity are frequent and, in most cases, benign. The primary aim of this study was to establish if there is a different follow-up necessity between HPV-positive compared to HPV-negative oral lesions. The secondary aim was to evaluate the recurrence of HPV-related lesions. All patients who underwent a surgical procedure of oral biopsy between 2018 and 2022, with ulterior histopathological examination and HPV typing, were examined. A total of 230 patients were included: 75 received traumatic fibroma as diagnosis, 131 HPV-related lesions, 9 proliferative verrucous leukoplakia, and 15 leukoplakia. The frequency and period of follow-up varied in relation to HPV positivity and diagnosis. This study confirms what has already been reported by other authors regarding the absence of recommendations of follow-up necessity in patients with oral mucosal lesions. However, the data demonstrate that there was a statistically significant difference in the sample analyzed regarding the follow-up of HPV-positive vs. HPV-negative patients. It also confirms the low recurrence frequency of HPV-related oral lesions.

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Section: Discussionmentioning

confidence: 99%

The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study

Rushiti,

Castellani,

Cerrato

et al. 2023

JCM

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“…cellular specimens from the mouth are rare. Besides, digestive enzymes, such as amylases and even RNAses from saliva, can be an obstacle to collections with low numbers of cells in different swabs [33][34][35]. Although there are no references, to the best knowledge of the authors, within studies on FOP pathophysiology regarding collection of BEC, for continuous gene expression analysis, show that this approach is still lacking in FOP studies.…”

Section: Journal Of Pre-clinical and Clinical Research Jpccrmentioning

confidence: 99%

Buccal epithelial cells as non-invasive biological material for fibrodysplasia ossificans progressiva gene expression studies

Messias,

Balaniuc,

Lima

et al. 2024

J Pre Clin Clin Res.

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“…The abundances of the phylum Fusobacteria, genus Fusobacterium, and phylum Bacteroidetes were found to be elevated in the saliva of patients with OSCC and were believed to be diagnostically specific [15]. Aside from viruses and bacteria, a variety of molecular and genetic markers can be detected for treatment and monitoring [87]. A recent study reported that oral-cancer-related microorganisms in the mucosa, other than in gingival plaque or saliva samples, have the most diverse species differences and functional changes and are the most suitable sites for observing microbial dysregulation [88].…”

Section: Diagnosis and Gradingmentioning

confidence: 99%

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

Wang,

Gao

2023

Current Oncology

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Microorganisms in the oral cavity are abundant in the human body. At present, more than 700 species of oral microorganisms have been identified. Recently, a lot of literature has indicated that the oral microbiota plays an important role in the occurrence, development, and prognosis of oral squamous cell carcinoma (OSCC) through various mechanisms. And researchers are now trying to utilize oral microbiota in cancer diagnosis and treatment. However, few articles systematically summarize the effects of oral microbes in the diagnosis, treatment, and disease outcomes of oral cancer. Herein, we made a summary of the microbial changes at cancerous sites and placed more emphasis on the mechanisms by which the oral microbiome promotes cancerization. Moreover, we aimed to find out the clinical value of the oral microbiome in OSCC.

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Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer

Cited by 14 publications

References 228 publications

The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study

The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study

Buccal epithelial cells as non-invasive biological material for fibrodysplasia ossificans progressiva gene expression studies

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

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