Saline irrigation for reducing the recurrence of common bile duct stones after lithotripsy: a randomized controlled trial

Lin, Yanyan; Yang, Man; Cao, Jie; Zhang, Xianzhuo; Mi, Ningning; Xiao, Yang; Wang, Haiping; Long, Gui‐Lu; Bai, Mingzhen; Fu, Wenkang; Li, Xun; Yue, Ping; Yuan, Jinqiu; Meng, Wenbo; Leung, Joseph

doi:10.1016/j.eclinm.2023.101978

Cited by 2 publications

(1 citation statement)

References 30 publications

(55 reference statements)

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“…In clinics, during endoscopic lithotomy, saline irrigation after mechanical lithotripsy has been demonstrated to be effective in reducing the recurrence rate of common bile duct stones, possibly by cleaning stone fragments [ 97 ]. In an animal model with chronic proliferative cholangitis, antibiotic irrigation effectively decreased the quantity of residual Escherichia coli in the biliary system and reduced the concentration of LPS and the expression of monocyte chemoattractant protein-1 (MCP1), cluster of differentiation 14 (CD14), cyclooxygenase-2, protein kinase C (PKC), Nuclear factor Kappa beta, C-myc, Interleukin(IL)-6, TNF-α, transforming growth factor-β1, β-glucuronidase, and MUC5AC [ 84 ].…”

Section: Bacterial Infections and Inflammationmentioning

confidence: 99%

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Zhao,

Yang,

et al. 2024

Biomolecules

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Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, further facilitating stone formation and growth. Moreover, gallstones may result in inflammation and the secretion of inflammatory factors, which can further increase mucin expression and secretion to promote the growth of gallstones. This review systematically summarises and analyses the role of mucins in gallstone occurrence and development and its related mechanisms to explore new ideas for interventions in stone formation or recurrence.

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Section: Bacterial Infections and Inflammationmentioning

confidence: 99%