2016
DOI: 10.1016/j.bpsc.2015.10.002
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Salience Network Functional Connectivity Predicts Placebo Effects in Major Depression

Abstract: Background Recent neuroimaging studies have demonstrated resting-state functional connectivity (rsFC) abnormalities among intrinsic brain networks in Major Depressive Disorder (MDD); however, their role as predictors of treatment response has not yet been explored. Here, we investigate whether network-based rsFC predicts antidepressant and placebo effects in MDD. Methods We performed a randomized controlled trial of two weeklong, identical placebos (described as having either “active” fast-acting, antidepres… Show more

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Cited by 63 publications
(90 citation statements)
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References 78 publications
(84 reference statements)
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“…Specifically, we wonder whether results would be similar if: a) the authors had included a PET study by Juengling et al (Juengling et al 2003), which studied brain metabolism at baseline in 12 medication-free BPD, without current substance abuse or depression, compared to 12 HC and b) had excluded the study by Soloff et al (Soloff et al 2005), given that its inclusion as a resting-state study might be thought by some readers to be limited by the fact that this was an experimentation of fenfluramine vs placebo and some evidence shows that placebo can alter the resting state (e.g. (Sikora et al 2016;Schmidt-Wilcke et al 2014)). …”
mentioning
confidence: 99%
“…Specifically, we wonder whether results would be similar if: a) the authors had included a PET study by Juengling et al (Juengling et al 2003), which studied brain metabolism at baseline in 12 medication-free BPD, without current substance abuse or depression, compared to 12 HC and b) had excluded the study by Soloff et al (Soloff et al 2005), given that its inclusion as a resting-state study might be thought by some readers to be limited by the fact that this was an experimentation of fenfluramine vs placebo and some evidence shows that placebo can alter the resting state (e.g. (Sikora et al 2016;Schmidt-Wilcke et al 2014)). …”
mentioning
confidence: 99%
“…Esta activación también aparece en otras situaciones como el "dolor", sugiriendo que existe un mecanismo neurobiológico del placebo común en distintas patologías. Recientemente, Sikora et al (2016), en un novedoso estudio sobre la conectividad funcional en estado de reposo y los efectos de los antidepresivos y el placebo, encontraron que el placebo inducía reducciones de esta actividad en la corteza cingulada anterior, y este hecho se relaciona con la disminución de los síntomas depresivos.…”
Section: Resumen De Los Resultadosunclassified
“…A continuación, se muestra el proceso mencionado de identificación, selección, elegibilidad e inclusión de los artículos en un diagrama de flujo. REVISIÓN SISTEMÁTICA, 2000-2016 Resultados encontrados en las bases de datos electrónicas (n=1.195) Excluidos por no cumplir criterios de inclusión (n=35):…”
Section: Objetivosunclassified
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