Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase

Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms

“…Therefore, it can be concluded that saffron enhances insulin sensitivity via multiple mechanisms. Consistent with our study, recent evidences provide that insulin-like natural compounds can improve insulin sensitivity by activating AMPK and PI 3-kinase/Akt pathways (Huang et al, 2010;Li, Ge, Zheng, & Zhang, 2008).…”

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

“…ability of compound C to suppress vascular endothelial growth factor-triggered phosphorylation of Akt in endothelial cells, 56 as well as insulin-dependent Akt activation in skeletal muscle cells. 57 Moreover, it should be noted that compound C belongs to a pyrazolopirymidine class of molecules, some of which are known to potently reduce Akt phosphorylation through blockade of Src kinase family. 58 Accordingly, our demonstration of the ability of been confirmed in the present study by using mTOR inhibitor rapamycin.…”

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

“…In L6 myotubes, these substances increased glucose uptake and reduced blood glucose in the myocytes of diabetic mice. Inhibition of salidroside-induced AMPK activity by Compound C in L6 myotubes suggests that this compound exerts its effects by activating AMPK ( 263 ).…”