Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury

Jin, Ping; Li, Lianghai; Shi, Yan; Hu, Nan-Bin

doi:10.1016/j.gene.2020.145075

Cited by 30 publications

(23 citation statements)

References 28 publications

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“…The expression of circ ACAP2 is induced by myocardial infarction which leads to increased cardiomyocyte apoptosis by sponging miR-29 (109). Salidroside inhibits apoptosis and autophagy of cardiomyocytes by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury (122). These data suggest that circRNAs may be the new targets for designing cardioprotective treatments against cardiomyocyte death.…”

Section: Circrna and Cvdsmentioning

confidence: 87%

Circular RNAs and Cardiovascular Regeneration

Tang

Jang

et al. 2021

Front. Cardiovasc. Med.

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circular RNAs (circRNAs) are a type of non-coding RNAs that are widely present in eukaryotic cells. They have the characteristics of stable structure, high abundance, and cell or tissue specific expression. circRNAs are single-stranded RNAs that are covalently back spliced to form closed circular loops. They may participate in gene expression and regulation through a variety of action modes. circRNAs can encode proteins or function by acting as miRNA sponges for protein translation. Since 2016, a growing number of research studies have shown that circRNAs play important role in the pathogenesis of cardiovascular disease. With the construction of circRNA database, the differential expression of circRNAs in the heart tissue samples from different species and the gradual elucidation of its mode of action in disease may become an ideal diagnosis biomarker and an effective therapeutic target. What can be expected surely has a broader application prospect. In this review, we summarize recent publications on circRNA biogenesis, expression profiles, functions, and the most recent studies of circRNAs in the field of cardiovascular diseases with special emphasis on cardiac regeneration.

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Section: Circrna and Cvdsmentioning

confidence: 87%

Circular RNAs and Cardiovascular Regeneration

Tang

Jang

et al. 2021

Front. Cardiovasc. Med.

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“…Coincidentally, circ-0000064 levels are increased by salidroside (Sal) pretreatment in the hearts of rats subjected to I/R injury, and circ-0000064 can ameliorate I/R-induced MI by inhibiting apoptosis and autophagy. 119 Sal treatment attenuates I/R-induced autophagy and protects cardiac function during MI by upregulating circ-0000064 expression. Moreover, circRNA ACR protects cardiac function by inhibiting A/R-induced autophagy and mitophagy.…”

Section: Circrnas and Cardiomyocyte Autophagymentioning

confidence: 99%

“…Unlike the abovementioned circRNAs, which exert therapeutic effects by affecting only one process involved in MI ( Table 2 ), many circRNAs affect multiple processes involved in MI and may exert therapeutic effects through various regulatory mechanisms simultaneously ( Table 3 ). For instance, circRNA ZNF292, circ-0000064, circHIPK2, and circRNA_101237 could be employed for their anti-apoptotic and anti-autophagic effects, 37 , 90 , 96 , 119 and circSAMD4A, circJARID2, and circMAT2B may have important anti-apoptotic and anti-inflammatory roles. 95 , 106 , 121 In addition, circ-0001273 probably exerts anti-apoptotic and reparative effects, 113 and circSNRK, circNFIX, circFndc3b, circPVT1, circ-Foxo3, and circAMOTL1 can have vital anti-apoptotic, proliferative, and proangiogenic effects.…”

Section: Circrna-based Approaches As Potential Therapeutic Strategies For MImentioning

confidence: 99%

Emerging roles of circRNAs in the pathological process of myocardial infarction

Wen

Hui

Wang

et al. 2021

Molecular Therapy - Nucleic Acids

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Myocardial infarction (MI) is defined as cardiomyocyte death in a clinical context consistent with ischemic insult. MI remains one of the leading causes of morbidity and mortality worldwide. Although there are a number of effective clinical methods for the diagnosis and treatment of MI, further investigation of novel biomarkers and molecular therapeutic targets is required. Circular RNAs (circRNAs), novel non-coding RNAs, have been reported to function mainly by acting as microRNA (miRNA) sponges or binding to RNA-binding proteins (RBPs). The circRNA-miRNA-mRNA (protein) regulatory pathway regulates gene expression and affects the pathological mechanisms of various diseases. Undoubtedly, a more comprehensive understanding of the relationship between MI and circRNA will lay the foundation for the development of circRNA-based diagnostic and therapeutic strategies for MI. Therefore, this review summarizes the pathophysiological process of MI and various approaches to measure circRNA levels in MI patients, tissues, and cells; highlights the significance of circRNAs in the regulation MI pathogenesis and development; and provides potential clinical insight for the diagnosis, prognosis, and treatment of MI.

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“…In another study, Wang et al found that the circDLGAP4/miR-143/BCL2 axis is a potential regulated axis in oxidative stress and myocardial IRI [ 97 ]. Upregulation of hsa_circ_0000064 (circ_0000064) weakened autophagy, reduced levels of lactate creatine kinase and dehydrogenase, inhibited oxidative stress, and significantly reduced myocardial infarction areas, signaling circ_0000064 had a protective effect against myocardial IRI [ 98 ]. Wang et al found that acting as an miR-223 sponge, the heart-related circRNA could sequester and inhibit the activity of miR-223, which is confirmed as an important regulator of cardiomyocyte apoptosis under oxidative stress [ 99 , 100 ].…”

Section: Regulatory Role Of Circrnas In Oxidative Stress: Implicatmentioning

confidence: 99%

Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Circular RNAs (circRNAs) are novel noncoding RNAs that play regulatory roles in gene expression. Dysregulation of circRNAs is associated with the development and progression of several diseases, such as diabetes mellitus, nervous system diseases, cardiovascular diseases, and cancer. CircRNAs functionally participate in cell physiological activities through various molecular mechanisms. However, these molecular mechanisms are unclear. Oxidative stress is an essential factor in the pathogenesis of various diseases, including neurological diseases. Emerging roles of circRNAs have been identified in different systems in response to oxidative stress. In this review, we summarize the current understanding of circRNA biogenesis, properties, expression profiles, and the clues indicating the regulatory roles of circRNAs through oxidative stress in various systems, especially the nervous system.

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Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury

Cited by 30 publications

References 28 publications

Circular RNAs and Cardiovascular Regeneration

Circular RNAs and Cardiovascular Regeneration

Emerging roles of circRNAs in the pathological process of myocardial infarction

Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases

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