Salidroside Attenuates Allergic Airway Inflammation Through Negative Regulation of Nuclear Factor-Kappa B and p38 Mitogen–Activated Protein Kinase

Abstract

Abstract. Salidroside is a biologically active ingredient of Rhodiola rosea, which has several interesting biological properties, including anti-oxidant and anti-inflammatory; however, its anti-allergic effects are poorly understood. The objective of this study is to determine whether salidroside attenuates the inflammatory response in an ovalbumin (OVA)-induced asthma model. OVA-sensitized/challenged mice show airway hyperresponsiveness (AHR) to inhaled methacholine and have an increased amount of T-helper2 type cytokines [interleukin (IL)-4, IL-5, and IL-13] and eosinophils in their bronchoalveolar lavage fluids and lung tissues. However, three successive intraperitoneal administrations of salidroside before the last OVA challenge result in significant inhibition of these asthmatic reactions. Moreover, OVA significantly increases the activation of nuclear factor-kappa B (NF-kB) and p38 mitogen-activated protein kinase (MAPK) in lung tissues, whereas salidroside markedly suppresses NF-kB translocation and reduces phosphorylation of p38 MAPK. Furthermore, salidroside attenuates the expression of intercellular adhesion molecule 1 and IL-6 through modulating the activities of p38 MAPK and NF-kB in the BEAS-2B cells stimulated by proinflammatory cytokines. These findings indicate that salidroside protects against OVA-induced airway inflammation and AHR, at least in part via downregulation of NF-kB and p38 MAPK activities. Our data support the utility of salidroside as a potential medicine for the treatment of asthma.

Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma

“…As described previously, p38, one of three major MAPKs, has been considered to play a key role in allergic asthma and also been significantly implicated in corticosteroid insensitivity . Our study has shown that the augmentation of asthmatic symptoms as well as the phosphorylation of p38 MAPK after OVA challenge is significantly inhibited after the administration of SB203580, a selective p38 MAPK inhibitor.…”

Paeonol Ameliorates Ovalbumin‐Induced Asthma through the Inhibition of TLR4/NF‐κB and MAPK Signaling

“…Recently, monomers of Chinese traditional herbs have attracted more and more attention because of their desirable pharmacological effects. Many monomers from Chinese medicine were valuable in the treatment of asthma, such as baicalin [ 11 ], salidroside [ 12 ], astragalus membranaceus [ 13 ], and luteolin [ 14 ]. Although most of these monomers were investigated in murine models, their therapeutic effects shown on asthma are promising.…”

Salidroside inhibits platelet‐derived growth factor–induced proliferation and migration of airway smooth muscle cells

“…Salidroside treatment regulates the T helper 1 (Th1)/Th2 balance, which plays an important role in asthma. 12 These findings lay the foundation for the antiasthmatic property of salidroside. 11 Besides, another in vivo study reveals that salidroside treatment results in an inhibitory effect on asthmatic reactions, which was illustrated by the decreased AHR to inhaled methacholine, reduced levels of Th2 cytokines including IL-4, IL-5, and IL-13 and eosinophils in BALF and lung tissues.…”

“…11 Besides, another in vivo study reveals that salidroside treatment results in an inhibitory effect on asthmatic reactions, which was illustrated by the decreased AHR to inhaled methacholine, reduced levels of Th2 cytokines including IL-4, IL-5, and IL-13 and eosinophils in BALF and lung tissues. 12 These findings lay the foundation for the antiasthmatic property of salidroside. However, the effects of salidroside on airway remodeling have not been elucidated.…”