Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway

Xu, Jianqing; Zhao, Long; Zhang, Xiangting; Ying, Kejing; Zhou, R.; Cai, Weimin; Xiao, Wei; Jiang, Haoran; Liu, Fangzhou; Miao, Dan; Zeng, Yun‐Yun; Yu, Fuxiang

doi:10.1016/j.ecoenv.2023.115331

Cited by 8 publications

(6 citation statements)

References 67 publications

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“…The liver serves as a central hub in the body’s defense system, playing a crucial role in metabolizing and detoxifying various chemicals and drugs. Some substances, such as acrylamide and acetaminophen, have been identified as potential contributors to liver injury [ 121 , 122 , 123 , 124 ]. Nevertheless, certain polyphenols have demonstrated significant potential in mitigating liver injury.…”

Section: Resultsmentioning

confidence: 99%

“…For instance, salidroside has been shown to alleviate acetaminophen-induced acute liver injury. Its mechanism involves inhibiting endoplasmic reticulum stress-dependent ferroptosis through the activation of AMPK/SIRT1 and the inhibition of the ATF4/CHAC1 axis [ 124 ]. Similarly, kaempferol was proven effective in ameliorating acetaminophen-induced liver injury.…”

Section: Resultsmentioning

confidence: 99%

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Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

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Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease. Polyphenols, plant secondary metabolites known for many bioactivities, are being extensively researched in the context of their influence on ferroptosis which resulted in a great number of publications showing the need for a systematic review. In this review, an extensive literature search was performed. Databases (Scopus, Web of Science, PubMed, ScienceDirect, Springer) were searched in the time span from 2017 to November 2023, using the keyword “ferroptosis” alone and in combination with “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, and “chalcone”; after the selection of studies, we had 311 papers and 143 phenolic compounds. In total, 53 compounds showed the ability to induce ferroptosis, and 110 compounds were able to inhibit ferroptosis, and out of those compounds, 20 showed both abilities depending on the model system. The most researched compounds are shikonin, curcumin, quercetin, resveratrol, and baicalin. The most common modes of action are in the modulation of the Nrf2/GPX4 and Nrf2/HO-1 axis and the modulation of iron metabolism.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Evidence shows that AMPK can be activated in response to ROS signaling under metabolic stress, including mitochondrial dysfunction and oxidative stress. A recent study has demonstrated that salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway [ 34 ]. Another study provided energy-stress-mediated AMPK activation-inhibited ferroptosis through regulating acetyl-CoA carboxylase phosphorylation mechanisms [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection

Du,

Wu,

Zhang

et al. 2023

Med Sci Monit

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Background C1q/tumor necrosis factor-related protein 13 (CTRP13) preserves endothelial function and possesses anti-oxidation activity. However, its effects on ferroptosis of human umbilical vein endothelial cells (HUVECs) remain unclear. We investigated the effects of CTRP13 on HUVEC ferroptosis induced by oxidized low-density lipoprotein (ox-LDL) and explored the underlying mechanisms of CTRP13 against ferroptosis via the AMPK/KLF4 pathway. Material/Methods Cell Counting Kit-8 assay was used to evaluate cell viability. Lactate dehydrogenase activity and malondialdehyde content analysis were performed to evaluate the cell membrane integrity and lipid peroxidation. Mito-Tracker, JC-1, and 2′,7′-dichlorofluorescein di-acetate were used to evaluate the biological activity of mitochondria, mitochondrial membrane potential, and reactive oxygen species (ROS) in endothelial cells. The ferroptosis indicator expressions, recombinant solute carrier family 7, member 11, glutathione peroxidase 4 (GPX4), and acyl-CoA synthetase long-chain family member 4 were examined using real-time reverse transcription-polymerase chain reaction and Western blot. Immunofluorescence staining detected GPX4 location in endothelial cells. Results The results demonstrate that CTRP13 (450 ng/mL) prevented HUVEC ferroptosis by inhibiting ROS overproduction and mitochondrial dysfunction, and CTRP13 accelerated antioxidant enzyme expression levels, such as heme oxygenase 1, superoxide dismutase 1, and superoxide dismutase 2, compared with the ox-LDL (100 μg/mL) group for 48 h. Additionally, CTRP13 treatment increased p-AMPK/AMPK expression by 47.65% ( P <0.05) while decreasing Krüppel-like factor 4 expression by 37.43% ( P <0.05) in ox-LDL-induced HUVECs and elucidated the protective effect on endothelial dysfunction from ferroptosis. Conclusions These findings provide new insights for understanding the effects and mechanism of CTRP13 on preventing endothelial cell ferroptosis.

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“…Tauroursodeoxycholic acid modulates the SIRT1/FXR signaling pathway beneficial in managing IRI during liver surgeries ( Sun et al, 2020 ). Pachymic acid maintains SIRT1 expression during oxygen-glucose deprivation/reoxygenation ( Xue et al, 2023a ; Xue et al, 2023b ).…”

Section: Survey Methodologymentioning

confidence: 99%

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

Wang,

Zhao,

Chen

et al. 2024

PeerJ

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Liver disease is a common and serious threat to human health. The progression of liver diseases is influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, and autophagy. Various factors lead to the dysfunction of these processes and basing on the different pathogeny, pathology, clinical manifestation, and pathogenesis, liver diseases are grouped into different categories. Specifically, Sirtuin1 (SIRT1), a member of the sirtuin protein family, has been extensively studied in the context of liver injury in recent years and are confirmed the significant role in liver disease. SIRT1 has been found to play a critical role in regulating key processes in liver injury. Further, SIRT1 seems to cause divers outcomes in different types of liver diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring a novel therapeutic target. To elucidate the mechanisms underlying the role of sirtuin1 in liver injury and its potentiality as a therapeutic target, this review outlines the key signaling pathways associated with sirtuin1 and liver injury, and discusses recent advances in therapeutic strategies targeting sirtuin1 in liver diseases.

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Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway

Cited by 8 publications

References 67 publications

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

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