Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats

Abstract

<jats:p>Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of SA coadministration with gentamicin. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde (MDA) levels and protein carbonyl groups indicated that GM-induced tissue injury was mediated through oxidative reactions. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules was found to be prevented by SA pretreatment. The results from our study indicate that SA supplement attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.</jats:p>

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

“…The current work revealed that gentamicin‐induced marked elevation in MDA level and decreased SOD and GST activities supporting the hypothesis that oxidative stress is involved in gentamicin‐induced nephrotoxicity . Either candesartan or EGCG exhibited potent antioxidant activity and decreased gentamicin‐induced nephrotoxicity, which was verified by restoring the oxidative balance.…”

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

“…Some of the previous studies have stated that the formation of free radicals as well as oxidative stress has played a crucial role in determining the nephrotoxic effect of GM. Using antioxidant therapy can assist in the prevention of such nephrotoxic effects (Randjelovic et al, ).…”

Sigma S-Dependent Antioxidant Defense Protects Stationary-Phase Escherichia coli against the Bactericidal Antibiotic Gentamicin

“…Thus, in mice, this drug significantly increases kidney myeloperoxidase activity, lipid peroxidation, and protein carbonylation. It has been shown that the resulting acute renal failure is caused by ROS, and the use of M40403, which is a low-molecular-weight mimetic of superoxide dismutase, attenuates this damage (64,65,75). Similarly, proteomic analysis implicates Gmmediated oxidative stress in Leishmania since the proteins affected by drug exposure included the thiol-redox control system (76).…”

“…We interpret this to show that, at higher concentrations, the ability of Gm to disrupt protein synthesis is strong enough not to be affected by the defective antioxidant defense of the mutant, but at a low concentration, the drug relies also on the added effect of oxidative stress to be effective. A strong enough attack on elements of the E. coli antioxidant defense, for example, by small-molecule inhibitors of the proteins identified above, should therefore enhance Gm effectiveness in combating this disease and permit the use of lower drug concentrations, thereby minimizing drug side effects such as nephrotoxicity (64,65).…”