Salicylate Ion‐Selective Electrode Based on a Calix[4]arene as Ionophore

Ayanoğlu, Melek Nur; Ertürün, H. Elif Kormalı; Özel, Ayça Demirel; Şahin, Özlem; Kılıç, Esma

doi:10.1002/elan.201400737

Cited by 12 publications

(11 citation statements)

References 55 publications

(46 reference statements)

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“…To the best of our knowledge, it is the first time to introduce a chemically modified carbon paste based sensor for salicylate determination and it proves to have good response characteristics among all the studied sensors. Also, the comparison of the CP based sensor ( B ) with the previously reported salicylate sensors 9–12, 63–65 showed superior characteristics in terms of response time, linear range and detection limit, with the exception of 11, 12 which have wider linear range (Table 4).…”

Section: Comparison Of the Proposed Sensors With Some Of The Reportmentioning

confidence: 85%

“…Therefore, the determination of sal − and its derivatives in pharmaceuticals and biological samples is vital. Several methods were reported for analysis of sal − including high performance liquid chromatography 4, fluorometry 5, UV spectrophotometry 6, 7, flow injection atomic absorption spectrometry 8, potentiometric 9–13 and voltammetry 14. Most of them are tedious and time‐consuming.…”

Section: Introductionmentioning

confidence: 99%

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Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

et al. 2013

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Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N‐2‐butenylated 2‐hydroxytryptamine, which underwent a base‐mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C‐ring. The second key step was a Pd‐catalysed cyclisation of an α‐keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N‐substituent) to form the D‐ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time.

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Section: Comparison Of the Proposed Sensors With Some Of The Reportmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

et al. 2013

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Section: Introductionmentioning

confidence: 99%

“…Up to date, several potentiometric ISEs were reported for salicylate determination . However, these sensors lacked adequate selectivity, needed long response time, applied in a small concentration range, and some of them used expensive ionophores . Thiourea (TU) and its derivatives (TUDs) are commercially available reagents and form very stable complexes with salicylate via Hydrogen bonding ,.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we reported a precise rGO‐modified CPE incorporating TUD1 as an ionophore, for the determination of salicylate in pharmaceutical formulations. Incorporating TUD1 into the ISEs for the electrochemical detection of salicylate overcome the disadvantages of the early reported sensors , and exhibited better selectivity over TUD2 and TUD3‐based sensors . The anion‐TUD1 interaction mechanism and geometry optimization were investigated theoretically at DFT‐B3LY/6‐31G** level of theory with energies calculations for HOMO and LUMO (E HOMO and E LUMO ) of the studied complexes.…”

Section: Introductionmentioning

confidence: 99%

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Carbon‐based Nanosensors for Salicylate Determination in Pharmaceutical Preparations

et al. 2019

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Thiourea derivative‐based carbon paste electrode (TUD1‐CPE) was constructed as a potentiometric sensor for the determination of salicylate anion in pharmaceutical formulations, Aspocid® and Aspirin®. The optimized CPE contained 45.5 % graphite, 0.5 % reduced graphene oxide (rGO), 46.0 % nitrophenyl octyl ether (NPOE) plasticizer, 5.0 % TUD1 ionophore, and 3.0 % tridodecylmethyl ammonium chloride as additive. The incorporation of NPOE of high dielectric constant, and rGO in electrode caused better performance of the sensor; Nernstian response of 59.0 mV decade−1 in the concentration range of 10−1–10−5 mole L−1, a detection limit of 1×10−5 mole L−1 in a very short response time of 6 seconds. The prepared sensor showed high selectivity against similar anions (i. e. ClO4- , benzoate, I−, SCN−). Selectivity was confirmed by calculating the formation constant (Kβ) using sandwich membrane method, where Kβ for TUD1‐salicylate is 100.43. Theoretical calculations at DFT‐B3LY/6‐31G** level of theory were performed to find interaction mechanism, Energies of HOMO and LUMO orbitals, non‐linear optical (NLO) properties (the electronic dipole moment (μ), first‐order hyperpolarizability (β), the hyper‐Rayleigh scattering (βHRS) and the depolarization ratio (DR)), and other global properties; these calculations showed lower values of β and DR, higher value of βHRS, and the shortest lengths of the four N−H bonds between TUD1 and salicylate which confirm their strong complexation and salicylate‐selectivity. Also, all the studied anion‐TUD1 exhibited relatively high NLO properties, and these results were considered as a preliminary study for investigating new types of NLO bearing materials. The sensors were applied successfully for the determination of salicylate anion in Aspocid® and Aspirin®.

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Potentiometric Sensing of Aspirin Metabolite in Human Plasma and Pharmaceutical Preparations Using Co(III)‐complex Based Electrodes: Experimental and Quantum Chemical Calculations

Shehab

Mansour

2016

Electroanalysis

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[a] 1Introduction Salicylate (sal À )i st he main metabolite coming from the hydrolysis of acetylsalicylate and its derivatives,w hich are extensively employed as an analgesic, inflammatory,a ntimicrobial agents,a nd also as ah eart attack protective in severalp harmaceuticalf ormulations [1][2][3].T he diagnosis of poisoning usually involves the determination of sal À in plasma. In general, the sal À level ranges from 30-100 mg/l after usual therapeutic doses, 50-300 mg/l with high doses and 700-1400 mg/l following acuteo verdose.I na ddition, salicylic acid is used as an antiseptic and ap reservative for foods and also applied in synthesis of dyes.T herefore, the determination of sal À and its derivatives in pharmaceuticals and biological samples is vital.S everal methods were reported for analysis of sal À including high performance liquid chromatography [4],f luorometry [5],U V spectrophotometry [6,7],f low injection atomic absorption spectrometry [8],p otentiometric [9-13] and voltammetry [14].M ost of them are tediousa nd time-consuming. In addition, Tr inderr eaction[ 15],a st he most widely used methodf or determination of sal À ,a lways lacks adequate selectivity due to the shortcomings of this reaction.In fact, direct potentiometric methodsb ased on ion-selective electrodes (ISEs) are of simpler design, lower cost, faster time,h igher selectivity,a nd employed for direct measurement of ionic species in the pharmaceutical and biological samples.T he design and synthesis of selective anion receptors that recognize anionic molecules is ag reat challenge for scientists. Theh ydration energy is high for big anions and this makes the receptors hard to sense these ions [16][17][18][19][20][21].Benzimidazole derivatives are also of wide interest because of their diverse biological activityand clinical applications as antihelmintic [22] Abstract:T hree novel poly vinyl chloride( PVC) (A), carbon paste (CP) (B), and coated glassy carbon-MWCNT (CGC) (C)s alicylate (sal, o-nitrophenyloctyl ether as amediator and tridodecylmethylammonium chloride as ac ationic additive were successfully usedf or determination of sal À in human plasma and pharmaceutical formulations.T he sal À -sensors exhibited enhanced sensitivity with slopeo fÀ63.5, À60.5 and À58.9 mV/decade and detection limit of 1.0 10 À5 , 4.0 10 À7 ,a nd 1.0 10 À6 mol L À1 for A-C sensors respectively.Q uantum chemicalc alculations were carried out by HF and DFT/B3LYP methodst oe xplore and investigate the interaction between the receptor and the different anions.T he intermolecular H-bondc reated between the uncoordinated C=Oofsalicylate group and the secondary amino groupi nt he complexi st he key factor of the selectivity of the proposed sensor. Al inear relation is established between the natural charge on the Co center and the value of the binding energy, where the decrease in positive charge is associated by an increase in the anionbinding energy.

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Salicylate Ion‐Selective Electrode Based on a Calix[4]arene as Ionophore

Cited by 12 publications

References 55 publications

Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

Total Synthesis of the Spirocyclic Oxindole Alkaloids Corynoxine, Corynoxine B, Corynoxeine, and Rhynchophylline

Carbon‐based Nanosensors for Salicylate Determination in Pharmaceutical Preparations

Potentiometric Sensing of Aspirin Metabolite in Human Plasma and Pharmaceutical Preparations Using Co(III)‐complex Based Electrodes: Experimental and Quantum Chemical Calculations

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