Salicylate Intoxication in Children

Hematologic perturbations associated with salicylate

“…102 Aspirin appears to decrease incidence of metastasis, possibly by its inhibition of platelet aggregation 24 , 37 or by inhibition of release of lysosomal enzymes as osteolytic substances. 67 89 Contrasting the report of Clausen and Jager,l1 the data of Ashworth and McKenzie 2 did not support a correlation of this effect with salicylate blood levels. Salicylates alter coagulation factor syn-thesis in the liver,50 interfering with production of Factors VII,72 IX, and X.38 Depression of blood levels of Factors VII, IX, and X becomes clinically significant after more than 6 gm per day and is reversed by vitamin K.95 Prothrombin times are rarely prolonged unless serum salicylate levels exceed 30 mg/100 ml.…”

Salicylates and Pandemic Influenza Mortality, 1918–1919 Pharmacology, Pathology, and Historic Evidence

“…ARDS-like disease has also been reported [53]. Children with aspirin toxicity (or Reye syndrome) are less likely than adults to present with pulmonary edema [35], although in addition to brain swelling, fatty liver, and cloudy swelling of the kidneys [54,55], some have pulmonary edema [55,56], "frothy, blood-tinged fluid" [57], and lung hemorrhages [54].…”