Salicylate Intoxication in Children

STEVENS, DOROTHY L.

doi:10.1001/archpedi.1945.02020230071013

Cited by 7 publications

(2 citation statements)

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“…102 Aspirin appears to decrease incidence of metastasis, possibly by its inhibition of platelet aggregation 24 , 37 or by inhibition of release of lysosomal enzymes as osteolytic substances. 67 89 Contrasting the report of Clausen and Jager,l1 the data of Ashworth and McKenzie 2 did not support a correlation of this effect with salicylate blood levels. Salicylates alter coagulation factor syn-thesis in the liver,50 interfering with production of Factors VII,72 IX, and X.38 Depression of blood levels of Factors VII, IX, and X becomes clinically significant after more than 6 gm per day and is reversed by vitamin K.95 Prothrombin times are rarely prolonged unless serum salicylate levels exceed 30 mg/100 ml.…”

Section: Salicylate-induced Hematologic Perturbations 147mentioning

confidence: 63%

Hematologic perturbations associated with salicylate

Rothschild

1979

Clin Pharma and Therapeutics

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Section: Salicylate-induced Hematologic Perturbations 147mentioning

confidence: 63%

Hematologic perturbations associated with salicylate

Rothschild

1979

Clin Pharma and Therapeutics

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“…ARDS-like disease has also been reported [53]. Children with aspirin toxicity (or Reye syndrome) are less likely than adults to present with pulmonary edema [35], although in addition to brain swelling, fatty liver, and cloudy swelling of the kidneys [54,55], some have pulmonary edema [55,56], "frothy, blood-tinged fluid" [57], and lung hemorrhages [54].…”

Section: The Pathology Of the Early Deaths Is Consistent With Aspirinmentioning

confidence: 99%

Salicylates and Pandemic Influenza Mortality, 1918–1919 Pharmacology, Pathology, and Historic Evidence

Starko

2009

CLIN INFECT DIS

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The high case-fatality rate--especially among young adults--during the 1918-1919 influenza pandemic is incompletely understood. Although late deaths showed bacterial pneumonia, early deaths exhibited extremely "wet," sometimes hemorrhagic lungs. The hypothesis presented herein is that aspirin contributed to the incidence and severity of viral pathology, bacterial infection, and death, because physicians of the day were unaware that the regimens (8.0-31.2 g per day) produce levels associated with hyperventilation and pulmonary edema in 33% and 3% of recipients, respectively. Recently, pulmonary edema was found at autopsy in 46% of 26 salicylate-intoxicated adults. Experimentally, salicylates increase lung fluid and protein levels and impair mucociliary clearance. In 1918, the US Surgeon General, the US Navy, and the Journal of the American Medical Association recommended use of aspirin just before the October death spike. If these recommendations were followed, and if pulmonary edema occurred in 3% of persons, a significant proportion of the deaths may be attributable to aspirin.

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