Salicylate-induced increases in free triiodothyronine in human serum

Larsen, P. Reed

doi:10.1172/jci106905

Cited by 164 publications

(28 citation statements)

References 20 publications

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“…This may support the earlier findings of decreased plasma PBI levels and increased T4 turnover (Musa et al 1968;Woeber 8c Ingbar 1964; Wolff 8c Austen 1958) or decreased serum Tg and T4 together with increased free dialyzable fractions of these hormones (Larsen 1972). The findings of a decreased 13,I uptake by thyroid after salicylate (Goldberg et al 1957;Austen et al 1958) were explained as being due to a thyromimetic effect of salicylate on the pituitary gland.…”

Section: Discussionsupporting

confidence: 81%

Short-Term Effect of Acetylsalicylic Acid Analogue on Pituitary-Thyroid Axis and Plasma Cortisol Level in Healthy Human Volunteers

Langer¹,

Földes²,

Michajlovskij³

et al. 1978

Acta Endocrinologica

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The effect of acetylsalicylic acid analogue (aloxiprinum; Superpyrin\s=r\ Spofa) administered perorally in a daily dose of 1 g per 10 kg body weight on serum levels of free thyroxine (FT4), total thyroxine (T4), triiodothyronine (T3), cortisol (F) and thyrotrophin (TSH) was studied in healthy human volunteers. In a first experiment the drug was administered for 3 days to 7 subjects, the total daily dose being divided into 4\ p=n-\ 5 aliquots, while the same total dose was administered within 4 h to another 8 subjects in a second experiment. In both experiments a highly significant increase of FT4 was found during the period of treatment, while the levels of other hormones i. e. (T3, T4, F and TSH) were decreased, in most cases significantly. After the withdrawal of the drug there was not only a return of all levels to the initial value, but in most cases an "overshoot" above this value was detected.The increase of oxygen consumption after salicylate has been known since 1916 (Denis 8c Means 1916). Even though a displacement of thyroxine from plasma protein binding sites has been suggested as an explanation of this effect (Wolff ') First

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Section: Discussionsupporting

confidence: 81%

Short-Term Effect of Acetylsalicylic Acid Analogue on Pituitary-Thyroid Axis and Plasma Cortisol Level in Healthy Human Volunteers

Langer¹,

Földes²,

Michajlovskij³

et al. 1978

Acta Endocrinologica

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“…Recently, several reports appeared on the action of diphenylhydantoin (Larsen et al 1970), heparin (Schwartz et al 1973), salicylate (Larsen 1972), barbiturates (Michajlovskij 8c Knopp 1973), univalent anions (Michajlovskip 8c Langer 1974) and other compounds (reviewed by Oppenheimer 1973) on various changes in the peripheral meta¬ bolism of thyroid hormones in vivo and thus numerous preceding studies in vitro by several investigators were confirmed. In these experiments and also in some unpublished studies, however, we failed to demonstrate any effect of heparin on T4 disappearance rate from plasma.…”

Section: Discussionmentioning

confidence: 95%

Acute Redistribution of Thyroxine After the Administration of Univalent Anions, Salicylate, Theophylline and Barbiturates in Rats

Langer

Kokesová

Gschwendtová

1976

Acta Endocrinologica

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Rats were injected with [125I]L-thyroxine (T4) ip 16 h before the experiment and samples of blood were frequently taken from polyethylene tubing inserted into the femoral artery in anaesthetized and heparin injected animals, isovolaemia being maintained. In each sample of plasma T4 counts per ml were estimated with the aid of paper chromatography. Rapid decrease of circulating T4 level was found at 20 min after iv injection of various compounds (thiocyanate, iodide, fluoroborate, theophylline and salicylate) and a dose-response relationship was established between such a decrease and the administered dose of salicylate (5\p=n-\160 mg/400 g b. w.). A similar decrease was observed at 60 min after ip injection of some general anaesthetics (thio-, pento-and allo-barbiturate, urethane) or tranquilizers (Innovar-Vet\s=r\).Finally, an increase of T4 fractional disposal rate was found between 120 and 480 min after the administration of some of the above mentioned anaesthetics and this effect was abolished by the administration of thiocyanate. It was concluded that there are two different effects of drugs on the circulating T4 level: 1. the immediate effect resulting apparently from a decreased plasma protein binding; 2. the prolonged effect which presumably results from the increased turnover of T4 by peripheral tissues, the metabolic basis of which remains unexplained.

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“…Thus, the free T4 concentration cannot be calculated. It is likely, however, that the serum free T4 concentration in these rats is increased because Larsen has reported that salicylate, when added to human serum at a concentration of 30 mg/dl, doubles the free T4 concentration as measured by an ultrafiltration technique (25). Serum TSH concentrations I and 2 h after administration of EMD 21388.…”

Section: Resultsmentioning

confidence: 97%

Rapid alteration in circulating free thyroxine modulates pituitary type II 5' deiodinase and basal thyrotropin secretion in the rat.

Abend¹,

Fang²,

Alex³

et al. 1991

J. Clin. Invest.

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TSH secretion is decreased by both T4 and T3. This negative feedback control of TSH secretion has been correlated with an increase in pituitary nuclear T3 content, and it is not clear whether T4 exerts its effect directly on the thyrotroph or after its deiodination to T3. However, levels of the pituitary enzyme catalyzing T4 to T3 conversion, 51)-II, are decreased in the presence of an increased amount of T4. Thus, it is unclear why the thyrotroph would have a mechanism for modulating the production of T3, if T3 is, in fact, the sole bioactive signal providing negative feedback inhibition.To examine this apparent paradox, we administered EMD 21388, a compound which inhibits the binding of T4 to transthyretin resulting in a rapid increase in circulating free T4 levels, to rats pretreated with radiolabeled T4 and T3. We observed increases in pituitary and liver T4 content of >150%, without increases in the respective tissue T3 contents. The EMD 21388-treated rats also exhibited a 25% decrease in pituitary 51)-II activity (103.8±15.8 fmol 125I released * mg protein-' h-1, vs. control, 137.4±15.9, mean±SE), as did rats treated with sodium salicylate, another compound that inhibits T4-TTR binding (100.8±7.1). TSH levels significantly decreased 2 h after the administration ofEMD 21388. These data demonstrate that despite a T4-mediated decrease in pituitary 5D-II activity, an increase in 14 independently decreases TSH secretion. (J. Clin. Invest. 1991. 88:898-903.)

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Salicylate-induced increases in free triiodothyronine in human serum

Cited by 164 publications

References 20 publications

Short-Term Effect of Acetylsalicylic Acid Analogue on Pituitary-Thyroid Axis and Plasma Cortisol Level in Healthy Human Volunteers

Short-Term Effect of Acetylsalicylic Acid Analogue on Pituitary-Thyroid Axis and Plasma Cortisol Level in Healthy Human Volunteers

Acute Redistribution of Thyroxine After the Administration of Univalent Anions, Salicylate, Theophylline and Barbiturates in Rats

Rapid alteration in circulating free thyroxine modulates pituitary type II 5' deiodinase and basal thyrotropin secretion in the rat.

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