Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury

Abstract

The growing importance of Salicornia plants as bioactive agents and health promoters associated with the continuous demand for alternative treatments for liver disorders, has stimulated us to evaluate the renal and hepatic effects of S. ramosissima seeds in mice under normal conditions and exposure to toxic products as carbon tetrachloride (CCl). Thus, histopathological and lipid peroxidation evaluations of the liver and kidneys were performed. Powdered dried seeds of S. ramosissima (SRS) were administered orally for 22 days at a dose of 2000 mg/kg/day to male mice in three different settings: 1) seed effects, 2) protection against CCl acute toxicity (0.2 mL/kg) and 3) regeneration after acute exposure to CCl (0.2 mL/kg), each study being performed with appropriate control animals. Mice treated with SRS per se had slightly enlarged hepatic sinusoids and noticeable renal inflammation. SRS did not show effective protection against mice exposed to CCl and had no positive influence on liver and kidney recovery after CCl administration. These results demonstrated that SRS failed to improve hepato- and nephrotoxicity, in addition to the apparent synergism between CCl and SRS under these experimental conditions. Although the biological mechanisms of S. ramosissima are not fully understood, the evidence suggests further research to elucidate its adverse biological effects.

Salicornia ramosissima Bioactive Composition and Safety: Eco-Friendly Extractions Approach (Microwave-Assisted Extraction vs. Conventional Maceration)

“…The beneficial effects of S. herbacea uses on cosmetics, healthy food supplement and pharmaceutical applications were already highlighted [9]. Nevertheless, as stated, most of these studies were performed in S. europaea and little is known regarding S. ramosissima that is considered an alternative to salt and whose leaves are used for human diet [10]. The main applications of this species are in salads, canned or gourmet gastronomy [4,10].…”

“…Nevertheless, as stated, most of these studies were performed in S. europaea and little is known regarding S. ramosissima that is considered an alternative to salt and whose leaves are used for human diet [10]. The main applications of this species are in salads, canned or gourmet gastronomy [4,10]. S. ramosissima can be found in salt marshes at the coastline of Europe from the Arctic to the Mediterranean [2,11].…”

A Review on Polyphenols in Salicornia ramosissima with Special Emphasis on Their Beneficial Effects on Brain Ischemia

“…However, this study investigated S. ramosissima as a skin cream application and further clinical studies are needed on the oral safety and tolerability of S. ramosissima polyphenol-rich extracts in humans. In this sense, preclinical studies support both the safety [ 142 ] and the use of S. ramosissima polyphenolic profile for the treatment of ischemia [ 13 , 143 ]. Moreover, Salicornia extracts from other Salicornia species have been better studied in neuroprotection, such as S. europaea [ 144 ] or S. herbacea [ 145 ].…”

Mast cells profiles and heterogeneity in lipopolysaccharide-induced uveitis model

“…For this reason, we investigated in vivo the profiles of MCs in the EIU, related to activation, maturation and heterogeneity, enhancing previous studies to better understand the biology of these cells in ocular inflammatory processes, especially in uveitis. The experiments were designed to minimize the number of animals used and their suffering during the execution of the protocols and are in accordance with other works developed by our research group [19,22]. To perform the histopathological, immunohistochemical and other set of experiments, the number of animals has been evaluated by PS Power© 3.0.…”