Abstract:ObjectivesTo investigate the effect and mechanisms of salicin (SA) on osteoarthritis (OA) progression.MethodsPrimary rat chondrocytes were stimulated with TNF-α and treated with or without SA. CCK-8 was utilized to determine the cytotoxicity of SA. RT-qPCR, Western Blotting and immunofluorescence staining were used to detect inflammatory factors, cartilage matrix degeneration markers, cell proliferation and apoptosis markers expression at mRNA and protein levels respectively. EdU assay and flow cytometer analy… Show more
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