Salen-manganese complex-based nanozyme with enhanced superoxide- and catalase-like activity for wound disinfection and anti-inflammation

Dai, Xiaomei; Xu, Qingqing; Liu, Yu; Yang, Lele; Zhang, Yongjie; Liu, Xiaojun; Gao, Feng

doi:10.1016/j.cej.2023.144694

Cited by 9 publications

(3 citation statements)

References 79 publications

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“…In the control group, cells were directly cultured on plates. H 2 O 2 was used to simulate the inflammatory microenvironment with oxidative properties [ 62 ]. The expression of iNOS (red) was significantly increased after H 2 O 2 stimulation (Fig.…”

Section: Resultsmentioning

confidence: 99%

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Xiao,

Tao,

et al. 2024

Nano-Micro Lett.

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Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine. This study proposes the use of diamond-like carbon (DLC) deposited on polylactic acid (PLA) membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats. The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane, with histological score decreasing from 3.12 ± 0.27 to 2.20 ± 0.22 and anti-adhesion effectiveness increasing from 21.61% to 44.72%. Mechanistically, the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively; thus, the phosphorylation of NF-κB and M1 polarization of macrophages are inhibited. Consequently, excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) is largely reduced. For biocompatibility evaluation, PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA membranes. Further studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds, which further delays the fibrosis process. It was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

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Section: Resultsmentioning

confidence: 99%

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Xiao,

Tao,

et al. 2024

Nano-Micro Lett.

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“…This study proposes “self-synergistic effects of nanomaterials”, in which one-component drugs use their inherent properties to enhance each other’s positive effects and/or reduce side effects, providing an effective strategy for drug development (Figure G) . The strategy has also received widespread attention, and has been verified and extended in other systems. − Material scientists, pharmacologists and chemists should be encouraged to pay more attention to the biological activity of nanodrugs. We have systematically studied and elaborated “PB as a photothermal conversion agent with good photothermal conversion properties”, − “the optimization strategy of PB as a photothermal conversion agent”, , and “the strategy of PB-mediated photothermal therapy combined with other therapeutic methods”, ,, which make nano PB as an ideal photothermal conversion agent, promoting the clinical transformation of PB as a photothermal conversion agent.…”

Section: A Photothermal Conversion Agentmentioning

confidence: 99%

Prussian Blue Nanoparticle: From a Photothermal Conversion Agent and a Drug Delivery System, to a Bioactive Drug

Gao,

Wang,

Zheng

et al. 2024

Acc. Mater. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Nanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine is on drug carriers: how to improve drug efficacy and reduce side effects. In order to further improve the synergistic and detoxifying effects of nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components and ignores the synergistic effects between components. The lack of in-depth research on the bioactivities of nanocarriers hinders the development and clinical translation of nanomedicine.In the past decade, scientists have gradually discovered that nanomaterials show excellent bioactivities, becoming an enormous treasure trove for disease prevention and treatment. Among numerous bioactive materials, Prussian blue (PB) is a clinical antidote approved by the US Food and Drug Administration, showing excellent biosafety. However, clinically approved PB owns many drawbacks, and it is difficult to satisfy the requirements of disease prevention and treatment. When the size reduces to the nanoscale, nano PB shows both unique properties of nanomaterials and the enhancement of its performance and bioactivities. Due to its easy-to-regulate structure and rich iron suspended bonds, nano PB may be a potential drug delivery system. Electron transition in the Fe-CN-Fe structure endows nano PB with strong absorbance in the near-infrared region, becoming a potential photothermal conversion agent. Furthermore, due to its rich redox potential and catalytic activities, nano PB may be a bioactive drug with a great translational clinic prospect.In this Account, we describe our exploration of nano PB as a photothermal conversion agent, a drug delivery system and a bioactive drug in the prevention and treatment of disease over the past decade. We first summarize the application of nano PB as a photothermal conversion agent and a drug delivery system in the treatment of cancer, and then focus on our recent progress in the application of nano PB as a bioactive drug in the prevention and treatment of diseases (such as tumors, neurodegeneration, cerebrovascular disease, bone-related degenerative disease, gastrointestinal disease, and skin lesions). Finally, we look forward to the open challenges and future developments in this rapidly developing field. We hope this Account will help readers understand nano PB not only as a photothermal conversion agent and drug carrier but also as a bioactive drug, thus realizing its great potential in disease prevention and treatment. These studies also provide a research paradigm for bioactive nanomaterials. As our and other teams continue to explore this promising material, the unique characteristics of bioactive nanomaterials represented by nano PB may bring further exciting developments in disease prevention and treatment.

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“…These factors may compromise treatment efficacy or lead to unnecessary side effects. In addition, oxidative stress and inflammatory response at the wound site cannot be ignored [ 19 , 20 ]. Thus, there is a demand for the development of natural, low-toxicity, straightforward, and cost-effective photosensitizers and antioxidant materials.…”

Section: Introductionmentioning

confidence: 99%

Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Yu,

Yang,

Zhao

et al. 2024

Materials Today Bio

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Salen-manganese complex-based nanozyme with enhanced superoxide- and catalase-like activity for wound disinfection and anti-inflammation

Cited by 9 publications

References 79 publications

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Prussian Blue Nanoparticle: From a Photothermal Conversion Agent and a Drug Delivery System, to a Bioactive Drug

Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

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