Salbutamol-Theophylline Interactions: Results of Adding Maximally Effective Doses of Theophylline to the Maximal Effects Obtainable from Salbutamol in Chronic Bronchitis

Abstract

3~measurements of lung function include the larynx as an in-series resistance to airflow it is important to know how the width of glottic chink varies in patients with lung disease. Patients undergoing fibre-optic bronchoscopy were studied; in each, lung function has been assessed by spirometry. From photographs of the vocal cords taken on inspiration and expiration via bronchoscopy, width of the glottic chink was assessed.Photographs were projected over a standard distance on to 1 mm-square graph paper and an area between the cords was obtained by counting squares. Area was divided by the anterwposterior diameter, a relatively invariant measurement, which provided a reference measurement, enabling correction for variations in photographic size due to differences in position of the bronchoscope and giving a measurement of width. A breathing trace obtained with a magnetometer and pneumotachograph was marked automatically for each photograph. Repeated photographs were taken during tidal breathing, panting and during a full exhalation.

A comparison of salbutamol and ipratropium in chronic bronchitis and chronic airflow limitation

“…The aim of bronchodilator therapy in patients with chronic bronchitis is to treat any airways obstruction that is reversible. B 2 ‐agonists administered in low doses by inhalation are comparatively poor bronchodilators in this disease, but in higher inhaled doses they may be more effective 6 , 7 . The vagal component of broncho‐constriction appears to be more prominent with increasing age and airflow obstruction 8 , and, when given by inhalation, IPB is an effective bronchodilator in patients with chronic airflow limitation 9 .…”

Pharmacokinetics and Pharmacodynamics of β₂-Agonists (in the Light of Fenoterol)

“…The changes in Rt and IGV were calculated as a percentage of the baseline value. Plethysmographic measurements were performed a t-1 0 .0 , 1,5,10,15,20,30,40,50,60. 90, 120, 180, and 240 min.…”

“…[34] described no better bronchodilatation after parenteral administration than after aerosol inhalation of terbutaline. Recommen dations for the dosages of drugs cannot be standardized since the amount required to stabilize the lung function optimally in patients with COAD varies [20,21], In these patients the indiviudal optimal dosage regimen has to be discovered by trial and error [35,36].…”