Salbutamol relative lung and systemic bioavailability of large and small spacers

Mazhar, Syed H. R.; Chrystyn, Henry

doi:10.1211/jpp/60.12.0006

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…This has been instituted in the Asthma Management Guidelines as a recommended practice in young children aged less than 12 years where the issue of poor pMDI technique is more evident [17], [18]. These recommendations towards the use of spacers have been based on the advantages these devices provide in terms of improved lung deposition of inhaled bronchodilators [13], [27] and inhaled corticosteroids [15], [28], accompanied with improved safety.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of asthma control, parents’ quality of life and preference between AeroChamber Plus and AeroChamber Plus Flow-Vu spacers in young children with asthma

Ammari

Toor²,

Chetcuti

et al. 2014

Journal of Asthma

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Objective: The AeroChamber Plus (AC) valved holding chamber has been enhanced to include the Flow-Vu (FV) inspiratory flow indicator that provides visual inhalation feedback during use. We have investigated if FV alters asthma control and whether parents accept it.Methods: At visit 1 children with asthma, age 1-5 years, used an AC with their pressurised metered dose inhaler and 2 weeks later (visit 2) they were randomised to use either AC or FV. Subjects returned 6 (visit 3) and 12 (visit 4) weeks later. The Asthma Control (ACQ) and Paediatric Asthma Caregiver's Quality of Life (PACQLQ) questionnaires were scored at each visit and their peak inhalation flow (PIF) when they used their spacer was measured.Results: Forty participants in each group completed the study. There was no difference in the ACQ scores from visits 2 to 4 between the 2 groups, whilst the improvements in the PACQLQ scores were greater in the FV group (p=0.029). The mean difference (95% confidence interval) for the change from visits 2 to 4 between FV and AC groups was 0.05 (-0.33, 0.43) and 0.39 (0.035, 0.737) for the ACQ and PACQLQ, respectively. Most parents preferred the FV (p<0.001). There was no difference in the PIF rates at each visit and between the two spacers. Conclusions:There was no change in asthma control of the young children but that of their parents improved. Parents preferred the FV and this could be related to their improved perception of their children's asthma control by better PACQLQ scores.Parent preference for spacer with visual feedback

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