Salbutamol inhalation has no effect on myocardial ischaemia, arrhythmias and heart‐rate variability in patients with coronary artery disease plus asthma or chronic obstructive pulmonary disease

Rossinen, Juhani; Partanen, Juhaní; Stenius-Aarniala, B; Nieminen, Markku S.

doi:10.1046/j.1365-2796.1998.00291.x

Cited by 34 publications

(19 citation statements)

References 24 publications

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“…Two-week salbutamol treatment increased baseline LF variability and LF/ HF variability ratio of ECG R-R intervals when compared to the placebo treatment. However, different results were obtained by Rossinen et al [20] who reported the commonly used doses of inhaled or nebulized salbutamol induced no acute myocardial ischaemia, arrhythmias or changes in HRV as assessed by Holter monitoring of 24 patients with coronary artery disease and clinically stable asthma or chronic obstructive pulmonary disease. A 4-week salmeterol treatment increased baseline HR, LF/HF variability ratio of R-R intervals.…”

Section: Discussionmentioning

confidence: 81%

Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients

et al. 2001

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Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients. B. Eryonucu, K. Uzun, N.Güler, M. Bilge. #ERS Journals Ltd 2001. ABSTRACT: This study investigated the effects of b 2 -adrenergic agonist therapy on heart rate variability (HRV) in adult asthmatic patients by using frequency domain measures of HRV.A randomized crossover design was used. Twenty adult patients with asthma were studied. All patients showed a mild-to-moderate decrease in baseline forced expiratory volume in one second. Any diseases that might have influenced the autonomic function were excluded. All patients had a complete physical examination and medical history that revealed no cardiovascular disease or medication. The study used 200 mg inhaled salbutamol and 500 mg inhaled terbutaline. HRV analysis was performed for each 5-min segment, 5 min before inhalation of the study drug and 5, 10, 15, 20, 25 and 30 min after inhalation. Total power (TP: v0.40 Hz), high-frequency power (HF: 0.15 -0.40 Hz), low-frequency power (LF: 0.04 -0.15 Hz) and LF/HF ratio were calculated.The LF and LF/HF ratio increased and TP decreased at 5, 10, 15 and 20 min after the salbutamol and the terbutaline inhalation, HF did not change significantly after the salbutamol and terbutaline inhalation.Acute salbutamol and terbutaline inhalation produce similar effects on heart rate variability and increase sympathetic modulation in the cardiac autonomic activity.

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Section: Discussionmentioning

confidence: 81%

Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients

et al. 2001

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“…Indirect evidence from four of the studies examining the impact of inhaled beta-2 agonist treatment in patients with chronic heart failure showed improved pulmonary function relative to placebo (8,9,11,12). Ng et al demonstrated a 6% improvement in FEV 1 (forced expiratory volume in the first second), and Rossinen et al showed a statistically significant increase in peak expiratory flow from 410 to 450 L/min (8,9). Uren et al demonstrated a statistically significant increase in FEV 1 from 2.28 to 2.38 L (11).…”

Section: Effect Of Acutely Delivered Beta-2 Agonists On Pulmonary Funmentioning

confidence: 99%

“…However, there is no evidence in the studies reviewed to suggest that acute beta-2 agonist administration increases or worsens myocardial ischemia, either from direct evidence in patients with ADHF or from indirect evidence in patients with chronic heart failure, and no electrocardiographic changes suggestive of ischemia were observed (8,9,15,18,20,22,23,25,26,28). In fact, Dawson et al showed that when albuterol was administered to 31 patients with myocardial infarction and cardiogenic shock, hemodynamics improved and no subject developed worsening ischemia (20).…”

Section: Effects Of Beta-2 Agonists In Heart Failure Patients With Acmentioning

confidence: 99%

Should Acute Treatment with Inhaled Beta Agonists be Withheld from Patients with Dyspnea Who May Have Heart Failure?

Maak¹,

Tabas²,

McClintock³

2011

The Journal of Emergency Medicine

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“…The criteria for exclusion were use of medication, anything other than the usual types of asthma medication during the previous 4 weeks (common antiasthma agents, e.g. beta-2 agonists such as salbutamol, do not influence heart rate variability [27]), psychosis, severe anxiety and/or depression, substance abuse, the current use of psychotropic medication [cf. [28,29,30] or psychotherapy as well as smoking and hypertension.…”

Section: Methodsmentioning

confidence: 99%

Pregnant Women with Bronchial Asthma Benefit from Progressive Muscle Relaxation: A Randomized, Prospective, Controlled Trial

Nickel

Lahmann²,

Muehlbacher

et al. 2006

Psychother Psychosom

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Background: Asthma is a serious medical problem in pregnancy and is often associated with stress, anger and poor quality of life.The aim of this study was to determine the efficacy of progressive muscle relaxation (PMR) on change in blood pressure, lung parameters, heart rate, anger and health-related quality of life in pregnant women with bronchial asthma. Methods: We treated a sample of 64 pregnant women with bronchial asthma from the local population in an 8-week randomized, prospective, controlled trial. Thirty-two were selected for PMR, and 32 received a placebo intervention. The systolic blood pressure, forced expiratory volume in the first second, peak expiratory flow and heart rate were tested, and the State-Trait Anger Expression Inventory and Health Survey (SF-36) were employed. Results: According to the intend-to-treat principle, a significant reduction in systolic blood pressure and a significant increase in both forced expiratory volume in the first second and peak expiratory flow were observed after PMR. The heart rate showed a significant increase in the coefficient of variation, root mean square of successive differences and high frequency ranges, in addition to a significant reduction in low and middle frequency ranges. A significant reduction on three of five State-Trait Anger Expression Inventory scales, and a significant increase on seven of eight SF-36 scales were observed. Conclusions: PMR appears to be an effective method to improve blood pressure, lung parameters and heart rate, and to decrease anger levels, thus enhancing health-related quality of life in pregnant women with bronchial asthma.

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Salbutamol inhalation has no effect on myocardial ischaemia, arrhythmias and heart‐rate variability in patients with coronary artery disease plus asthma or chronic obstructive pulmonary disease

Abstract: The commonly used doses of inhaled or nebulized salbutamol induced no acute myocardial ischaemia, arrhythmias or changes in heart rate variability in patients with CAD and clinically stable asthma or COPD.

Cited by 34 publications

References 24 publications

Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients

Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients

Should Acute Treatment with Inhaled Beta Agonists be Withheld from Patients with Dyspnea Who May Have Heart Failure?

Pregnant Women with Bronchial Asthma Benefit from Progressive Muscle Relaxation: A Randomized, Prospective, Controlled Trial

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