Salbutamol in the Management of Asthma: A Review

Marques, Lara; Vale, Nuno

doi:10.3390/ijms232214207

Cited by 16 publications

(8 citation statements)

References 149 publications

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“…Upon absorption, these drugs undergo distribution throughout the organism, with variable volumes of distribution (Vd). For instance, salbutamol typically exhibits a Vd of approximately 3-4 L/kg [21], and budesonide has a Vd of 2.2-3.9 L/kg. The metabolism of anti-asthmatic drugs primarily ensues in the hepatic milieu via diverse enzymatic pathways, yielding variable clearance rates.…”

Section: Discussionmentioning

confidence: 99%

Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba

Santos,

da Hora Borges,

Jatobá da Silva

et al. 2024

Pharmaceutics

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The compound 6-methoxyseselin, derived from Zanthoxylum tingoassuiba, demonstrates various therapeutic properties, including vasorelaxation, antinociceptive, anti-inflammatory, and immunomodulatory effects, along with recently discovered antiasthmatic properties. This study aimed to evaluate its preclinical pharmacokinetics and pulmonary delivery in Balb/c mice. The method involved administering the compound via inhalation and intravenous routes, followed by blood sample collection for analysis using high-performance liquid chromatography with diode array detection (HPLC-DAD). The results indicated good linearity, precision, accuracy, and stability of the compound in the biological samples. Pharmacokinetic parameters such as the rate of elimination, half-life, clearance, volume of distribution, area under the curve, and mean residence time were determined for both administration routes, showing similar profiles. The lung concentrations were notably higher than the plasma concentrations, indicating significant lung penetration. These findings suggest 6-methoxyseselin as a promising candidate for new anti-asthmatic drugs, supported by its favorable pharmacokinetic profiles and high lung penetration factors. This study represents the first exploration of the pharmacokinetics and pulmonary delivery of 6-methoxyseselin in mice, highlighting its potential for further drug development.

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Section: Discussionmentioning

confidence: 99%

Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba

Santos,

da Hora Borges,

Jatobá da Silva

et al. 2024

Pharmaceutics

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show abstract

“…Finally, the mdrun command was used for a 50 ns simulation. In addition, salbutamol is a representative drug for treating asthma ( Marques and Vale, 2022 ). Evidence of the synergy between the lead compound and salbutamol in treating asthma was obtained through literature research and molecular dynamics simulation was used to get the functional and mechanistic understanding involved.…”

Section: Methodsmentioning

confidence: 99%

Micro-simulation insights into the functional and mechanistic understanding of glycyrrhizin against asthma

Qi,

Xu,

Wang

et al. 2023

Front. Pharmacol.

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Asthma is a common chronic respiratory disease, which causes inflammation and airway stenosis, leading to dyspnea, wheezing and chest tightness. Using transgelin-2 as a target, we virtually screened the lead compound glycyrrhizin from the self-built database of anti-asthma compounds by molecular docking technology, and found that it had anti-inflammatory, anti-oxidative and anti-asthma pharmacological effects. Then, molecular dynamics simulations were used to confirm the stability of the glycyrrhizin-transgelin-2 complex from a dynamic perspective, and the hydrophilic domains of glycyrrhizin was found to have the effect of targeting transgelin-2. Due to the self-assembly properties of glycyrrhizin, we explored the formation process and mechanism of the self-assembly system using self-assembly simulations, and found that hydrogen bonding and hydrophobic interactions were the main driving forces. Because of the synergistic effect of glycyrrhizin and salbutamol in improving asthma, we revealed the mechanism through simulation, and believed that salbutamol adhered to the surface of the glycyrrhizin nano-drug delivery system through hydrogen bonding and hydrophobic interactions, using the targeting effect of the hydrophilic domains of glycyrrhizin to reach the pathological parts and play a synergistic anti-asthmatic role. Finally, we used network pharmacology to predict the molecular mechanisms of glycyrrhizin against asthma, which indicated the direction for its clinical transformation.

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“…Teosal merupakan obat golongan Short-acting B2-agonists (SABA) dengan komposisi salbutamol dan bronkodilator bekerja dengan cara menghambat kontraksi otot polos bronkus pada pasien asma (Marques & Vale, 2022). Prednisone dan dexamethasone merupakan obat golongan kortikosteroid yang bekerja dengan cara mengambat pelepasan mediator inflamasi dan menekan reaksi imun sehingga dapat mencegah timbulnya gejala pada pasien asma yang dikonsumsi secara rutin setiap hari untuk mengurangi keparahan gejala asma (Rozaliyani et al, 2011) (Steffensen et al, 2010;Stratakis, 2016).…”

Section: Pemberian Pendidikan Kesehatan Bukan Hanya Sekedar Pemberian...unclassified

Pencegahan Kekambuhan Asma dan Pengelolaan Cushing Syndrome: Studi Kasus

Tsauroh,

Kurniawan,

Sari

2024

Mal Health Stu J.

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Latrogenic cushing syndrome is a complication for asthma patients due to long-term use of steroid drugs. This risk is increasingly higher as the recurrence rate in increases asthma patients (poor asthma control). Asthma management has been shown to be effective in reducing asthma recurrence, there’s limited literature how to manage asthma in patients with cushing’s syndrome. This study aims to explain how to implement management and prevention of asthma recurrence in cushing syndrome patients undergoing treatment at one of regional general hospitals in the West Java. This case study uses a descriptive design described narratively. A woman (56) was admitted to the adult internal medicine room with weakness, breathlessness and itching. The face looks round (moonface), there’s fat on the shoulder (buffalo hump), lines (striae) appear on abdomen. Patients has history of asthma since kid. Family said patient had been taking corticosteroid medication for± 10 years. Patient claimed unaware about managing asthma. Asthma Control Test score before intervention was given 11 (not controlled). During treatment, patient and their families receive nursing intervention, pharmacology therapy, education and discussion about asthma management and how to prevent asthma recurrence that can reduce of using corticosteroid. At the end of intervention, patient and their family expressed better knowledge about asthma management. Symptoms of weakness, breathlessness, and itching had subsided by the end of treatment period. Patient had started asthma management after being discharged from hospital, but the smoke-free home had not been implemented optimally so patient relapsed once on the fourth day of discharged from hospital. Asthma management education is an effective strategy in prevention and management of cushing syndrome in asthma patients, however management will not be optimal without family support and those closest to them. Education provided during treatment needs to be followed up during the post-treatment period through regular follow up to ensure that programmed treatment can run as it should Keywords: Asthma, Asthma Management, Case Study, Cushing Syndrome ABSTRAK Latrogenic cushing syndrome adalah salah satu komplikasi bagi pasien asma akibat penggunaan obat steroid jangka panjang. Resiko ini semakin tinggi seiring tingginya angka kekambuhan pasien asma (asma kontrol buruk). Manajemen asma telah terbukti efektif dalam mengurangi kekambuhan asma, sedikit literatur mendiskusikan bagaimana manajemen asma pada pasien dengan cushing syndrome. Case study ini bertujuan untuk memaparkan bagaimana implementasi pengelolaan dan pencegahan kekambuhan asma pada pasien cushing syndrome yang menjalani perawatan di salah satu rumah sakit umum daerah di wilayah Jawa Barat. Studi kasus ini menggunakan desain deskriptif dan diuraikan secara naratif. Seorang perempuan (56 thn) dirawat di ruang penyakit dalam dewasa dengan keluhan lemas, sesak, dan gatal. Wajah tampak bulat (moonface), pada daerah bahu terdapat penumpukan lemak (buffalo hump), tampak guratan garis (striae) pada abdomen. Pasien memiliki riwayat asma sejak kecil. Keluarga mengatakan bahwa pasien mengkonsumsi obat kortikosteroid ketika asma kambuh selama ± 10 tahun. Pasien mengatakan belum mengetahui terkait mengelola asma yang baik agar tidak kambuh. Skor Asthma Control Test sebelum diberikan intervensi adalah 11 (tidak terkontrol). Selama dirawat pasien dan keluarga diberikan intevernsi keperawatan, terapi farmakologi dan menerima edukasi dan diskusi mengenai manajemen asma yang baik dan cara pencegahan kekambuhan asma sehingga dapat mengurangi penggunaan obat kortikosteroid. Diakhir masa perawatan, pasien dan keluarga menyatakan paham mengenai manajemen asma. Keluhan lemas sudah tidak ada, sesak dan gatal berkurang. Setelah pulang dari rumah sakit, keluarga mengatakan telah mengurangi faktor pencetus kekambuhan asma pada pasien, namun rumah bebas asap rokok belum dilakukan secara maksimal oleh keluarga sehingga pasien kambuh satu kali di hari keempat pulang rawat. Edukasi manajemen asma merupakan strategi yang efektif dalam pencegahan dan pengelolaan cushing syndrome pada pasien asma, namun meski dimikian pengelolaan tidak akan maksimal tanpa dukungan keluarga dan orang terdekat. Edukasi yang diberikan selama dirawat perlu untuk ditindak lanjuti selama masa pasca rawat melalui follow up secara berkala untuk menjamin perawatan yang diprogramkan dapat berjalan sebagaimana mestinya. Kata Kunci: Asma, Cushing Syndrome, Manajemen Asma, Studi Kasus

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Salbutamol in the Management of Asthma: A Review

Cited by 16 publications

References 149 publications

Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba

Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba

Micro-simulation insights into the functional and mechanistic understanding of glycyrrhizin against asthma

Pencegahan Kekambuhan Asma dan Pengelolaan Cushing Syndrome: Studi Kasus

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