Salazinic acid attenuates male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic albino rats

Killari, K. N.; Polimati, Haritha; Prasanth, D. S. N. B. K.; Singh, Gagandeep; Panda, Siva Prasad; Vedula, Girija Sastry; Tatipamula, Vinay Bharadwaj

doi:10.1039/d3ra01542d

Cited by 6 publications

(7 citation statements)

References 41 publications

(82 reference statements)

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“…Neurodegenerative diseases pose significant health challenges that impose substantial cost burdens on ageing and elderly populations [39]. The existing literature mainly indicates that individuals with AD commonly have impairment in cholinergic activity.…”

Section: Discussionmentioning

confidence: 99%

“…Scopolamine-induced dementia has been widely employed in assessing putative therapeutic interventions for treating AD [39,48]. The study conducted by MT et al [70] demonstrated that the administration of scopolamine in mice brains impacts the expression of many genes related to muscarinic receptor signaling pathways, apoptosis, and cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…This cascade of events ultimately damages cholinergic neurons and subsequent cognitive impairments [58]. The administration of SCO has been found to induce oxidative stress, which is considered one of the primary mechanisms responsible for cell damage [39]. In the present investigation, the administration of SCO resulted in the induction of oxidative stress, as evidenced by a notable reduction in the levels of crucial brain antioxidant defenses, namely glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities.…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacokinetic and drug similarity predictions for substances were conducted using the online program ADMETSAR (http://lmmd.ecust. edu.cn/admetsar1/, Accessed on 12 September 2023) [38,39]. Pharmacokinetic and drug similarity predictions were used to assess Lipinski using the DruLito program [40].…”

Section: Drug Likeliness and Adme/t Analysismentioning

confidence: 99%

“…Computational methods for predicting ADMET properties, such as in silico forms, have become increasingly popular. These methods offer several advantages over traditional in vitro methods, including being faster, cheaper, and potentially more lifesaving [39]. In silico processes use computer models and algorithms to predict a compound's ADMET properties based on its chemical structure and other relevant factors without animal models.…”

Section: Drug Likeliness and Admet Analysismentioning

confidence: 99%

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Citronellal as a Promising Candidate for Alzheimer’s Disease Treatment: A Comprehensive Study on In Silico and In Vivo Anti-Acetylcholine Esterase Activity

Prasanth,

Shadakshara

et al. 2023

Metabolites

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One of the primary therapeutic approaches for managing Alzheimer’s disease (AD) involves the modulation of Acetylcholine esterase (AChE) activity to elevate acetylcholine (ACh) levels inside the brain. The current study employed computational chemistry approaches to evaluate the inhibitory effects of CTN on AChE. The docking results showed that Citronellal (CTN) and standard Donepezil (DON) have a binding affinity of −6.5 and −9.2 Kcal/mol, respectively, towards AChE. Further studies using molecular dynamics (MD) simulations were carried out on these two compounds. Binding free energy calculations and ligand-protein binding patterns suggested that CTN has a binding affinity of −12.2078. In contrast, DON has a much stronger binding relationship of −47.9969, indicating that the standard DON has a much higher binding affinity than CTN for AChE. In an in vivo study, Alzheimer-type dementia was induced in mice by scopolamine (1.5 mg/kg/day i.p) for 14 days. CTN was administered (25 and 50 mg/kg. i.p) along with scopolamine (SCO) administration. DON (0.5 mg/kg orally) was used as a reference drug. CTN administration significantly improved the mice’s behavior as evaluated by the Morris water maze test, evident from decreased escape latency to 65.4%, and in the CPS test, apparent from reduced escape latency to 69.8% compared to the positive control mice. Moreover, CTN significantly increased the activities of antioxidant enzymes such as catalase and superoxide dismutase (SOD) compared to SCO. Furthermore, CTN administration significantly decreased SCO-induced elevated AChE levels in mice. These results were supported by histopathological and in silico molecular docking studies. CTN may be a potential antioxidant and neuroprotective supplement.

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Section: Discussionmentioning

confidence: 99%