Salad and Pseudoappendicitis:<i>Yersinia pseudotuberculosis</i>as a Foodborne Pathogen

Tauxe, Robert V.

doi:10.1086/381806

Cited by 23 publications

(15 citation statements)

References 18 publications

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“…25 Y. pseudotuberculosis is also a food-borne pathogen and mainly causes enteritis or tuberculosis-like symptoms in infected animals. 26,27 EPEC is another major agent of infantile diarrhea and is associated with high mortality rates. 28 For all these pathogens, we observed a 30 to 70% decrease in pathogenicity when host cells were pre-treated with BL21-MAM7.…”

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confidence: 99%

Turnabout is fair play

2012

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confidence: 99%

Turnabout is fair play

2012

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“…In fact, pain to the right lower quadrant with systemic signs of inflammation and elevated inflammatory markers in blood might be due to quiet a handful of pathologies [4, 5]. Especially bowel pathologies including right sided colitis, ileitis or gastroenteritis might present with similar signs and symptoms thus mimicking AA [6, 7]. The spectrum of possible differential diagnosis even gets wider in female patients in reproductive age.…”

Section: Introductionmentioning

confidence: 99%

Improving the Preoperative Diagnostic Accuracy of Acute Appendicitis. Can Fecal Calprotectin Be Helpful?

et al. 2016

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BackgroundIs the patient really suffering from acute appendicitis? Right lower quadrant pain is the most common sign of acute appendicitis. However, many other bowels pathologies might mimic acute appendicitis. Due to fear of the consequences of delayed or missed diagnosis, the indication for emergency appendectomy is liberally made. This has been shown to be associated with high rates of negative appendectomy with risk of potentially serious or lethal complications. Thus there is need for a better preoperative screening of patients with suspected appendicitis.MethodsThis prospective single center single-blinded pilot study was conducted in the Department of surgery at the HELIOS Universitätsklinikum Wuppertal, Germany. Calprotectin was measured in pre-therapeutic stool samples of patients presenting in the emergency department with pain to the right lower quadrant. Fecal calprotectin (FC) values were analyzed using commercially available ELISA kits. Cut-off values for FC were studied using the receiver-operator characteristic (ROC) curve. The Area under the curve (AUC) was reported for each ROC curve.ResultsThe mean FC value was 51.4 ± 118.8 μg/g in patients with AA, 320.9 ± 416.6 μg/g in patients with infectious enteritis and 24.8 ± 27.4 μg/g in the control group. ROC curve showed a close to 80% specificity and sensitivity of FC for AA at a cut-off value of 51 μg/g, AUC = 0.7. The sensitivity of FC at this cut-off value is zero for enteritis with a specificity of 35%.ConclusionFecal calprotectin could be helpful in screening patients with pain to the right lower quadrant for the presence of acute appendicitis or infectious enteritis with the aim of facilitating clinical decision-making and reducing the rate of negative appendectomy.

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“…These were traced to YPST contamination in a school canteen (Interfax News, 2006). Yersinia pseudotuberculosis has been implicated in foodborne illness associated with iceberg lettuce, vegetable juice, sandwiches, barbecue, school lunches, pasteurized milk and pork (Tsubokura et al., 1989; Nowgesic et al., 1999; Public Health Agency of Canada, 1999; Nuorti et al., 2004; Tauxe, 2004) and also isolated from beef (Toma, 1986; Chiesa et al., 1993; Welsh and Stair, 1993), bovine feces (Fukushima et al., 1983), pork (Kot et al., 2007) and from the gastrointestinal tract of calves suffering from enteritis (Callinan et al., 1988; Slee et al., 1988; Brown and Davis, 1989). In ground beef processing plants, different portions of beef are combined and ground.…”

Section: Introductionmentioning

confidence: 99%

Growth Model of a Plasmid‐Bearing Virulent Strain of Yersinia pseudotuberculosis in Raw Ground Beef

Bhaduri

Phillips

2011

Zoonoses and Public Health

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The growth kinetics of virulence plasmid-bearing Yersinia pseudotuberculosis (YPST) in sterile ground beef were studied at temperatures ranging from 0 to 30°C. In irradiated sterile ground beef, YPST replicated from 0 to 30°C, with corresponding growth rates (GR) ranging from 0.023 to 0.622 log CFU/h at 0-25°C, and the GR was 0.236 log CFU/h at 30°C. The maximum population densities (MPD) ranged from 8.7 to 11.0 log CFU/g. The growth and MPD of YPST were reduced significantly at 30°C. Models for GR and MPD of YPST in raw ground beef (RGB) as a function of storage temperatures were produced and displayed acceptable bias and accuracy. The models were validated with rifampicin-resistant YPST (rif-YPST) in sterile ground beef stored at 4, 10 and 25°C. The observed GR and MPD were within 95% of the predicted values. When compared to non-sterile retail ground beef, the growth of rif-YPST was not inhibited and displayed similar GR at 0, 10 and 25°C and MPDs as sterile ground beef at 10 and 25°C. Moreover, there was no loss of virulence plasmid in YPST during its growth in ground beef indicating that RGB contaminated with virulence plasmid-bearing YPST could cause disease due to refrigeration failure, temperature (10-25°C) abuse, and if the meat was not properly cooked.

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Salad and Pseudoappendicitis:Yersinia pseudotuberculosisas a Foodborne Pathogen

Cited by 23 publications

References 18 publications

Turnabout is fair play

Turnabout is fair play

Improving the Preoperative Diagnostic Accuracy of Acute Appendicitis. Can Fecal Calprotectin Be Helpful?

Growth Model of a Plasmid‐Bearing Virulent Strain of Yersinia pseudotuberculosis in Raw Ground Beef

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