Saksenaea vasiformis infections: A case of an immunocompetent adult after mild injury and a literature review

Samaras, Konstantinos; Markantonatou, Anthi-Marina; Karapiperis, Dimitrios; Digonis, Polidoros; Kartalis, Nikolaos; Kostogloudis, Nikolaos; Vyzantiadis, Timoleon‐Achilleas

doi:10.1016/j.mycmed.2019.06.005

Cited by 7 publications

(10 citation statements)

References 55 publications

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“…Posaconazole was added to amphotericin B in four patients. 7 , 11 , 31 , 32 Posaconazole was used as the sole agent in none of the reported cases.…”

Section: Resultsmentioning

confidence: 99%

“…All nine case reports have been surgically debrided; four cases were managed by surgical reconstructive procedures. 7 , 11 , 17 , 32 Detailed information on reconstructive procedures is listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…and referred to it as Saksenaea vasiformis. 11,12 The clinical presentation of infections with Saksenaea spp. varies between localized or systemic disease.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Invasive Fungal Infections with Saksenaea Species in Immunocompetent Patients in Europe: A Systematic Review and Case Report

Planegger

Uyulmaz

Poskevicius³

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Background: Invasive fungal infections from Saksenaea, a fungus belonging to the Mucorales, have been rarely reported in central European climate zones. This study aims to raise awareness of invasive cutaneous infections with Saksenaea species. The first case of a cutaneous infection was diagnosed in Switzerland in an immunocompetent 79-year-old patient. A minor skin trauma of her left lower leg led to a fulminant infection causing necrosis and extensive loss of tissue. The combination of surgical debridement and administration of antifungal agents averted a prolonged course with a possible worse outcome. A pedicled hemisoleus muscle flap was used to reconstruct the defect and treatment was continued for 63 days. Methods: A systematic review in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis guidelines was conducted to identify all European cases of infection with Saksenaea species in immunocompetent hosts. The epidemiology, clinical presentation, microbiological diagnosis, and management of cases reported in Europe were summarized and analyzed. Conclusions: The prognosis of soft tissue infections with Saksenaea species. depends on early diagnosis and appropriate antifungal and surgical treatment. Reconstruction can be successful under ongoing antifungal treatment.

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“…Posaconazole was added to amphotericin B in four patients. 7 , 11 , 31 , 32 Posaconazole was used as the sole agent in none of the reported cases.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cutaneous Invasive Fungal Infections with Saksenaea Species in Immunocompetent Patients in Europe: A Systematic Review and Case Report

Planegger

Uyulmaz

Poskevicius³

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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“…Saksenaea vasiformis infection was first reported in the facial wounds of a young man following an accident in 1976 [ 5 ]. Subsequently, 46 cases have been documented [ 6 ]. S. vasiformis orbital involvement is extremely rare with 3 published cases associated with sinusitis [ 3 , 7 , 8 ] and 1 individual with isolated orbital infection after aquatic exposure [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Orbital Infection by Saksenaea vasiformis in an Immunocompetent Host

Lumyongsatien

Jaru-Ampornpan

Uiprasertkul

et al. 2020

Case Reports in Ophthalmological Medicine

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Orbital mucormycosis caused by Saksenaea vasiformis is extremely rare. Herein, we report an immunocompetent 22-year-old Thai female who presented with two months of progressive right upper eyelid mass, associated with swelling, redness, and ptosis. She failed to improve despite multiple courses of antibiotic and steroid treatment. Computed tomography (CT) scan showed infiltration involving the upper eyelid and lacrimal gland. Fungal hyphae were revealed by histopathological study. Polymerase chain reaction (PCR) was positive for Saksenaea vasiformis (GenBank: accession number FR687327.1). The patient was successfully treated with surgical debridement, amphotericin B, and oral posaconazole.

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“…are increasingly reported as the cause of human infection, mostly but not limited to tropical and subtropical areas [12]. Unlike other members of the order Mucorales, Saksenaea infections usually affect immunocompetent hosts, and are often associated with trauma [13]. To our knowledge, there have been six cases of disseminated Saksenaea infection reported; these are summarized in Table 1 [14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: a case report and review of the literature

et al. 2020

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Background Saksenaea species (spp.) are uncommon causes of mucormycosis but are emerging pathogens mostly associated with trauma and soil contamination often in immunocompetent hosts. Due to lack of sporulation in the laboratory, diagnosis and susceptibility testing is difficult so optimal treatment regimens are unknown. Case presentation A 67 year-old man from the Northern Territory in Australia, with a history of eosinophilic granulomatosis with polyangiitis, developed disseminated Saksenaea infection after initially presenting with symptoms consistent with bacterial pyelonephritis. Despite a delay in diagnosis; with aggressive surgical management and dual therapy with amphotericin B and posaconazole, he survived. Conclusions We describe an unusual case of disseminated infection with a favourable outcome to date.

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Saksenaea vasiformis infections: A case of an immunocompetent adult after mild injury and a literature review

Cited by 7 publications

References 55 publications

Cutaneous Invasive Fungal Infections with Saksenaea Species in Immunocompetent Patients in Europe: A Systematic Review and Case Report

Cutaneous Invasive Fungal Infections with Saksenaea Species in Immunocompetent Patients in Europe: A Systematic Review and Case Report

Orbital Infection by Saksenaea vasiformis in an Immunocompetent Host

Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: a case report and review of the literature

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