Saikosaponin A Inhibits Growth of Human Bladder Carcinoma T24 and 5637 Cells Both &lt;i&gt;in Vitro&lt;/i&gt; and &lt;i&gt;in Vivo&lt;/i&gt;

Zhou, Qian; Wu, Weiwei; Yu, Chunlei; Wang, Peng; Wen, Xiao-Qian; Chen, Bi-Ling; Zhang, Ying; Zhuang, Min; Zhang, Meng-Ying; Zhang, Haoyuan; Zhang, Jianwu

doi:10.1248/bpb.b21-01025

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Another study showed that Saikosaponin A (SSA) had therapeutic potential in the treatment of oxidative liver injury through multiscale interactome-level analysis combined with experiments [ 61 ]. SSA also inhibited human bladder cancer T24 both in vitro and in vivo [ 62 ], while SSA extract had anticancer effects by inhibiting cell proliferation and inducing apoptosis in 5637 cells [ 63 ]. Saikosaponin D (SSD) could attenuate cancer cachexia by directly inhibiting signal transducer and activator of transcription 3 (STAT3) expression [ 64 ] as well as attenuate peripheral neuropathy in diabetic rats by regulating the Aquaporin 1 (AQP1)/Ras homolog family member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway [ 65 ].…”

Section: Multiple Pharmacological Effects Of Bupleurummentioning

confidence: 99%

Bupleurum in Treatment of Depression Disorder: A Comprehensive Review

Ran,

Peng,

Guo

et al. 2024

Pharmaceuticals

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The incidence of depression has been steadily rising in recent years, making it one of the most prevalent mental illnesses. As the pursuit of novel antidepressant drugs captivates the pharmaceutical field, the therapeutic efficacy of Traditional Chinese Medicine (TCM) has been widely explored. Chaihu (Bupleurum) has been traditionally used for liver conditions such as hepatitis, liver inflammation, liver fibrosis, and liver cancer. It is believed to have hepatoprotective effects, promoting liver cell regeneration and protecting against liver damage. In addition, Bupleurum has also been used as a Jie Yu (depression-relieving) medicine in China, Japan, Republic of Korea, and other Asian countries for centuries. This review article aims to summarize the research conducted on the antidepressant properties and mechanisms of Bupleurum, as well as discuss the potential of TCM formulas containing Bupleurum. This review highlights various antidepressant ingredients isolated from Bupleurum, including saikosaponin A, saikosaponin D, rutin, puerarin, and quercetin, each with distinct mechanisms of action. Additionally, Chinese herb prescriptions and extracts containing Bupleurum, such as Chaihu Shugansan, Xiaoyaosan, and Sinisan, are also included due to their demonstrated antidepressant effects. This review reveals that these Bupleurum compounds exhibit antidepressant effects through the regulation of neurotransmitter mechanisms (such as 5-HT and DA), the NMDA (N-methyl-D-aspartate) system, brain-derived neurotrophic factor (BDNF), and other intracellular signaling pathways. Collectively, this comprehensive review provides insights into the multiple applications of Bupleurum in the treatment of depression and highlights its potential as an alternative or complementary approach to traditional therapies. However, it is essential to consider the potential adverse effects and clinical restrictions of Bupleurum despite its promising potential. Further research is needed to elucidate its specific mechanisms of action and evaluate its effectiveness in human subjects.

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Section: Multiple Pharmacological Effects Of Bupleurummentioning

confidence: 99%

Bupleurum in Treatment of Depression Disorder: A Comprehensive Review

Ran,

Peng,

Guo

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression

Lan

Wen

Zeng

et al. 2023

Biochemical and Biophysical Research Communications

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TCM targets ferroptosis: potential treatments for cancer

Qin,

Zhong,

et al. 2024

Front. Pharmacol.

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Ferroptosis is caused by the accumulation of cellular reactive oxygen species that exceed the antioxidant load that glutathione (GSH) and phospholipid hydroperoxidases with GSH-based substrates can carry When the antioxidant capacity of cells is reduced, lipid reactive oxygen species accumulate, which can cause oxidative death. Ferroptosis, an iron-dependent regulatory necrosis pathway, has emerged as a new modality of cell death that is strongly associated with cancer. Surgery, chemotherapy and radiotherapy are the main methods of cancer treatment. However, resistance to these mainstream anticancer drugs and strong toxic side effects have forced the development of alternative treatments with high efficiency and low toxicity. In recent years, an increasing number of studies have shown that traditional Chinese medicines (TCMs), especially herbs or herbal extracts, can inhibit tumor cell growth and metastasis by inducing ferroptosis, suggesting that they could be promising agents for cancer treatment. This article reviews the current research progress on the antitumor effects of TCMs through the induction of ferroptosis. The aim of these studies was to elucidate the potential mechanisms of targeting ferroptosis in cancer, and the findings could lead to new directions and reference values for developing better cancer treatment strategies.

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Saikosaponin A Inhibits Growth of Human Bladder Carcinoma T24 and 5637 Cells Both <i>in Vitro</i> and <i>in Vivo</i>

Cited by 3 publications

References 37 publications

Bupleurum in Treatment of Depression Disorder: A Comprehensive Review

Bupleurum in Treatment of Depression Disorder: A Comprehensive Review

Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression

TCM targets ferroptosis: potential treatments for cancer

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