Sagittal Abdominal Diameter Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Incident Peritoneal Dialysis Patients

Lee, Mi Jung; Shin, Dong Ho; Kim, Seung Jun; Yoo, Dong Eun; Ko, Kwang Il; Koo, Hyang Mo; Kim, Chan Ho; Doh, Fa Mee; Oh, Hyung Jung; Park, Sun-Hee; Han, Seung Hyeok; Yoo, Tae Hyun; Choi, Kyu Hun; Kang, Shin Wook

doi:10.1371/journal.pone.0077082

Cited by 10 publications

(9 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One prospective, population-based study of adults demonstrated that SAD contributed significantly to the prediction of incident diabetes in models including BMI [41], and a longitudinal study of patients with type 2 diabetes reported that SAD was superior to waist circumference or BMI for predicting incident cardiovascular events [42]. Other studies have documented associations between SAD and mortality in selected, high-risk populations [43,44]. …”

Section: Discussionmentioning

confidence: 99%

Comparison of adiposity indicators associated with fasting-state insulinemia, triglyceridemia, and related risk biomarkers in a nationally representative, adult population

Kahn

Cheng

2018

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Aims We hypothesized that height-corrected abdominal size (supine sagittal abdominal diameter/height ratio [SADHtR] or waist circumference/height ratio [WHtR]) would associate more strongly than body mass index (BMI, weight/height2) with levels of fasting insulin, triglycerides, and three derived biomarkers of insulin resistance. Methods Anthropometry, including SAD by caliper, was collected on 4398 adults in the 2011–2014 National Health and Nutrition Examination Survey. For comparison purposes, each adiposity indicator was scaled to its population-based, sex-specific, interquartile range (IQR). For each biomarker we created four outcome groups based on equalsized populations with ascending values. Multivariable polytomous logistic regression modeled the relationships between the adiposity indicators and each biomarker. Results Highest-group insulin was associated with a one-IQR increment of BMI (RR 4.3 [95% CI 3.9–4.9]), but more strongly with a one-IQR increment of SADHtR (RR 5.7 [5.0–6.6]). For highest-group HOMA-IR the RR for BMI (4.2 [3.7–4.6]) was less than that of SADHtR (6.0 [5.1–7.0]). Similarly, RRs for BMI were smaller than those for SADHtR applying to highest-group triglycerides (RR 1.6 vs 2.1), triglycerides/HDL-cholesterol (RR 1.9 vs 2.4) and TyG index (RR 1.7 vs 2.2) (all p < .001). The RRs for WHtR were consistently between those for SADHtR and BMI. The top 25% of insulin resistance among US adults was estimated to lie above adiposity thresholds of 0.140 for SADHtR, 0.606 for WHtR, or 29.6 kg/m2 for BMI. Conclusions Relative abdominal size rather than relative weight may better define adiposity associated with homeostatic insulin resistance. These population-based, cross-sectional findings could improve anthropometric prediction of cardiometabolic risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of adiposity indicators associated with fasting-state insulinemia, triglyceridemia, and related risk biomarkers in a nationally representative, adult population

Kahn

Cheng

2018

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

show abstract

“…Most identified causes of sudden natural death ( n = 54) were aortic diseases ( n = 30). Others suggested that in individuals without a definite radiologically identified cause of sudden natural death it was due to coronary artery disease and numerous studies found an association between abdominal adiposity and cardiovascular disease . The cellular lipid content determines the size of adipocytes; large, mature adipoctyes were filled almost entirely by large lipid droplets .…”

Section: Discussionmentioning

confidence: 99%

Relationship between sudden natural death and abdominal fat evaluated on postmortem CT scans

Kaichi

Sakane

Higashibori

et al. 2017

Obesity Science & Practice

View full text Add to dashboard Cite

SummaryObjectiveThis study examined the association between sudden natural death and abdominal fat using postmortem computed tomography (CT) scans.Subjects and methodsPostmortem CT images at the umbilical level of 241 subjects were used to measure abdominal areas of subcutaneous‐ and visceral fat, the rate of visceral fat and the waist circumference. Of the study subjects, 174 died of sudden natural death (130 men and 44 women), and 67 died of different causes (46 men and 21 women). All were between 40 and 75 years of age. Logistic regression analysis was performed to identify independent abdominal parameters associated with sudden natural death.ResultsBy univariate analysis, the areas of subcutaneous and visceral fat were significantly larger in sudden natural death than who died of different causes (subcutaneous fat, odds ratio [OR] = 1.004, 95% confidence interval [CI] = 1.000–1.007, p = 0.03; visceral fat, OR = 1.008, 95% CI = 1.003–1.013, p < 0.01). Multivariate analysis showed that the area of visceral fat was an independent factor associated with the risk of sudden natural death (OR = 1.008, 95% CI = 1.002–1.015, p = 0.02).ConclusionsPostmortem CT revealed that sudden natural death was related to abdominal fat deposits.

show abstract

“…In this study, we used anthropometric data from the US National Health and Nutrition Examination Survey (NHANES) to address: 1) Sex differences in SAD in the entire population as well as in the subgroups characterized by age, race/ethnicity, education, birth place, and household income; 2) Sex differences in socio-economic correlates of SAD. Considering the important role of sex in cardiovascular diseases 16 and the important role of SAD in obesity-related health risks, [5][6][7][8][9] our ndings will provide useful insights for investigating cardiometabolic risk separately in men and women.…”

Section: Introductionmentioning

confidence: 94%

“…4,5 SAD has beeen linked to increased risks of cardiometabolic disorders [5][6][7] and mortality. 8,9 Women are reported to have lower intra-abdominal/visceral adiposity than men while the difference is diminished and not consistently seen in the elderly [10][11][12] . It remains relatively unknown whether SAD, as a manifest measure of visceral adiposity, differs by sex in the general population and in the subgroups de ned by socio-economic characteristics.…”

Section: Introductionmentioning

confidence: 99%

Sagittal Abdominal Diameter and its Socioeconomic Correlates: Perspective of Sex Differences

Harris

Tsilimingras

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Sagittal abdominal diameter (SAD) is an anthropometric index associated with visceral adiposity. It remains unclear whether SAD and its socio-economic correlates differ in women and men, which limits the epidemiological and clinical applications of the SAD measurement. The aims of this study are to examine the sex differences in SAD and its socio-economic correlates.Methods A complex stratified multistage clustered sampling design was used to select 6,975 men and 7,079 women aged 18 years or more from the National Health Nutrition and Examination Survey 2011-2016, representative of the US civilian non-institutionalized population. SAD was measured in accordance to the standard protocols using a two-arm abdominal caliper. The sex differences in SAD and its socio-economic correlates were evaluated by performing weighted independent t tests and weighted multiple regression. Results SAD was lower in women than in men in the entire sample, as well as in all the subgroups characterized by age, race, birth place, household income, and body mass index except for non-Hispanic blacks and those with household income < $20,000. Adjusted for other characteristics, age, birth place, household income, and body mass index were associated with SAD in both women and men. Black women were associated with higher SAD then white women (p<.0001), and Hispanic and Asian men were associated with lower SAD than white men (both p<.01). Women born in other countries were more likely to have lower SAD than women born in the US (p<.0001), and so were men (p=.0118). Both women and men with a household income of <$75,000 had higher SAD than those with an income of over $75,000. The associations of age, race, and household income with SAD differed in women and men.Conclusion SAD is lower in women than in men, in the general population as well as in the most socio-economic subgroups. While socio-economic correlates of SAD are similar in women and men, the associations of age, race, and household income with SAD vary across sex.

show abstract

Sagittal Abdominal Diameter Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Incident Peritoneal Dialysis Patients

Cited by 10 publications

References 42 publications

Comparison of adiposity indicators associated with fasting-state insulinemia, triglyceridemia, and related risk biomarkers in a nationally representative, adult population

Comparison of adiposity indicators associated with fasting-state insulinemia, triglyceridemia, and related risk biomarkers in a nationally representative, adult population

Relationship between sudden natural death and abdominal fat evaluated on postmortem CT scans

Sagittal Abdominal Diameter and its Socioeconomic Correlates: Perspective of Sex Differences

Contact Info

Product

Resources

About