Many materials contain extended defects of nanosize scale, such as dislocations, cracks, pores, polymorphic inclusions, and other embryos of competing phases. When one is interested not in the precise internal structure of a sample with such defects, but in its overall properties as a whole, one needs a statistical picture giving a spatially averaged description. In this chapter, an approach is presented for a statistical description of materials with extended nanosize defects. A method is developed allowing for the reduction of the problem to the consideration of a set of system replicas representing homogeneous materials characterized by effective renormalized Hamiltonians. This is achieved by defining a procedure of averaging over heterophase configurations. The method is illustrated by a lattice model with randomly distributed regions of disorder.