Saffron in Persian traditional medicine

Yousefi, Mahdi; Shafaghi, Khosro

doi:10.1016/b978-0-12-818638-1.00025-3

Cited by 5 publications

(7 citation statements)

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“…He even recommended saffron baths for the men under his command. The Greek soldiers, taken with saffron's perceived curative properties, continued the practice after returning to Macedonia 21 …”

Section: Application Of Saffron In the Persian Civilization Tradition...mentioning

confidence: 99%

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Survey of the History and Applications of Saffron

Asgari

Abdi

et al. 2022

Chinese Medicine and Culture

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Fan Hong Hua ( saffron) is a natural product that has long been used in food and dye industries and fortreating various disorders. Saffron has a long history of applications in traditional Chinese medicine, following its introduction to China in 1979. According to the theory of traditional Chinese medicine, saffron is sweet, slightly cold in nature and enters heart and liver meridians. Moreover, this spice can invigorate blood circulation, eliminate blood stasis, cool blood and eliminate heat toxins. Saffron has been used to treat asthma, phlegm, insomnia, Alzheimer's disease, depression, fright, shock, hemoptysis, heartburn, and pain. Among the almost 70 bioactive ingredients of saffron, major constituents of this herb include safranal, crocin, and crocetin, which are responsible for the unique taste and color of saffron. These ingredients have been investigated using modern pharmaceutical research methods as potential therapeutics to treat disorders such as Alzheimer's disease, cardiovascular diseases, cancer, digestive system disorders, ocular issues, and COVID-19 infections. However, focus and emphasis on understanding the pharmacological effects of saffron in treating diseases are required. This article briefly reviews the history, cultivation processes, different qualities properties, and traditional and modern applications of this unique herb.

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Section: Application Of Saffron In the Persian Civilization Tradition...mentioning

confidence: 99%

“…The Greek soldiers, taken with saffron's perceived curative properties, continued the practice after returning to Macedonia. 21 Persian medicine is one of the most famous traditional and holistic systems of medicine. Saffron is a potent and important drug in this medical system.…”

Section: Application Of Saffron In the Persian Civilization Tradition...mentioning

confidence: 99%

Survey of the History and Applications of Saffron

Asgari

Abdi

et al. 2022

Chinese Medicine and Culture

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“…27,29,30 Also, for many centuries, in other traditional Iranian medicine manuscripts, the efficacy of saffron in skin diseases, eyes problems, headaches, melancholia, wounds healing, diarrhea, liver and spleen diseases, and depression has been reported. 19,31,32 An example of manuscript of traditional medicine reference books describing the therapeutic uses of saffron is shown in Figure 1 to 3. [33][34][35] Moreover, in recent studies, saffron has been proved to be clinically useful in improving symptoms of diabetes, Parkinson's disease, sexual disorders, atherosclerosis, depression, and cancers are benefits of this plant.…”

Section: Saffron In Ancient Medicinementioning

confidence: 99%

Use of saffron against dementia in Traditional Persian Medicine: A historical perspective

Marzabadi¹

2021

Erciyes Med J

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“…Commonly, it is utilized in European regions, including Spain, Greece, and Italy, and also in regions of Asia, like India and Iran . Traditionally, it is known to have therapeutic effects on palpitation according to Persian, Ayurvedic, and Chinese medicine …”

Section: Introductionmentioning

confidence: 99%

“… 8 Traditionally, it is known to have therapeutic effects on palpitation according to Persian, Ayurvedic, and Chinese medicine. 9 …”

Section: Introductionmentioning

confidence: 99%

Analysis of Anti-Arrhythmic Impacts of Crocin through Estimation of Expression of Cx43 in Myocardial Infarction Using a Rat Animal Model

Wang

et al. 2022

ACS Omega

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Arrhythmia is an important cause of death after myocardial infarction (MI). Different substances have been evaluated for their anti-arrhythmic effect in MI. This study was performed to evaluate the anti-arrhythmic impacts of crocin in an MI animal model (rat) by estimation of the expression of connexin 43 (Cx43). Fifty male Sprague–Dawley rats were grouped into 5 groups, each composed of 10 rats. The first group was regarded as the normal control group and the second one was considered as the MI group, which was caused by ligation of the left anterior descending artery. The other three groups received crocin 50 or 10 mg/kg/day or metoprolol 100 mg/kg/day for 1 week, following ligation of the left anterior descending artery. Evaluated outcomes were cardiac Cx43 expression, arrhythmia incidence, histological findings, and myocyte resting potential. Crocin-treated MI groups showed a significantly lower arrhythmia score than the non-treated MI group, 10 mg/kg/day (1.85 ± 0.55, p < 0.01) and 50 mg/kg/day (1.70 ± 0.33, p < 0.01). Groups that received crocin 10 mg/kg/day (66.30 ± 2.59, p < 0.01), crocin 50 mg/kg/day (68.10 ± 2.43, p < 0.01), and metoprolol 100 mg/kg/day (−63.54 ± 0.63 mV, p < 0.01) significantly prevented depolarization in comparison with the non-treated MI group. Expression of Cx43 mRNA in crocin 10 mg/kg/day (1.54 ± 0.24, p < 0.01), crocin 50 mg/kg/day (1.73 ± 0.09, p < 0.01), and metoprolol 100 mg/kg/day (1.75 ± 0.14, p < 0.01) treatment groups was significantly higher in comparison with the non-treated MI group. Crocin showed a preventive effect on the arrhythmogenic impact of MI in an experimental model of ischemic injury through an increase in expression of Cx43.

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Saffron in Persian traditional medicine

Cited by 5 publications

References 0 publications

Survey of the History and Applications of Saffron

Survey of the History and Applications of Saffron

Use of saffron against dementia in Traditional Persian Medicine: A historical perspective

Analysis of Anti-Arrhythmic Impacts of Crocin through Estimation of Expression of Cx43 in Myocardial Infarction Using a Rat Animal Model

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