Saffron anti-metastatic properties, ancient spice novel application

Arzi, Laleh; Hoshyar, Reyhane

doi:10.1080/10408398.2020.1871320

Cited by 13 publications

(2 citation statements)

References 76 publications

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“…Crocin (Figure 3) is a carotenoid and one of the major constituents derived from saffron, Crocus sativus [203]. Crocin has been shown to have anticancer effects such as inhibiting tumor growth, inducing cell death, and inhibiting tumor invasion [204,205].…”

Section: Crocinmentioning

confidence: 99%

Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms

Bajalia

Azzouz

Chism

et al. 2022

Cancers

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Renal cell carcinoma (RCC) is associated with about 90% of renal malignancies, and its incidence is increasing globally. Plant-derived compounds have gained significant attention in the scientific community for their preventative and therapeutic effects on cancer. To evaluate the anticancer potential of phytocompounds for RCC, we compiled a comprehensive and systematic review of the available literature. Our work was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. The literature search was performed using scholarly databases such as PubMed, Scopus, and ScienceDirect and keywords such as renal cell carcinoma, phytochemicals, cancer, tumor, proliferation, apoptosis, prevention, treatment, in vitro, in vivo, and clinical studies. Based on in vitro results, various phytochemicals, such as phenolics, terpenoids, alkaloids, and sulfur-containing compounds, suppressed cell viability, proliferation and growth, showed cytotoxic activity, inhibited invasion and migration, and enhanced the efficacy of chemotherapeutic drugs in RCC. In various animal tumor models, phytochemicals suppressed renal tumor growth, reduced tumor size, and hindered angiogenesis and metastasis. The relevant antineoplastic mechanisms involved upregulation of caspases, reduction in cyclin activity, induction of cell cycle arrest and apoptosis via modulation of a plethora of cell signaling pathways. Clinical studies demonstrated a reduced risk for the development of kidney cancer and enhancement of the efficacy of chemotherapeutic drugs. Both preclinical and clinical studies displayed significant promise of utilizing phytochemicals for the prevention and treatment of RCC. Further research, confirming the mechanisms and regulatory pathways, along with randomized controlled trials, are needed to establish the use of phytochemicals in clinical practice.

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Section: Crocinmentioning

confidence: 99%

Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms

Bajalia

Azzouz

Chism

et al. 2022

Cancers

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“…Many in vivo studies in animals have indicated a very low or even non-existent toxicity of both saffron and its extracts [ 3 ]. In recent years, in-depth studies of saffron found that it is a rich source of multiple active ingredients, including carotenoids, flavonoids, and terpenoids [ 4 ]. At present, the most widely studied bioactive compounds in saffron are safranal, crocin, and picrocrocin [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Identification and Functional Validation of Two Novel Antioxidant Peptides in Saffron

Long,

Tao,

Wang

et al. 2024

Antioxidants

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Saffron (Crocus sativus L.) is one of the most expensive spices in the world, boasting rich medicinal and edible value. However, the effective development of active natural substances in saffron is still limited. Currently, there is a lack of comprehensive studies on the saffron stigma protein, and the main effect peptides have not been identified. In this study, the total protein composition of saffron stigmas was analyzed, and two main antioxidant peptides (DGGSDYLGK and VDPYFNK) were identified, which showed high antioxidant activity. Then, the stability of two peptides was further evaluated. Furthermore, our results suggested that these two peptides may protect HepG2 cells from H2O2-induced oxidative damage by significantly improving the activity of endogenous antioxidant enzymes and reducing the malondialdehyde (MDA) content. Collectively, we identified two peptides screened from the saffron protein possessing good antioxidant activity and stability, making them promising candidates for use as functional foods, etc., for health promotion. Our findings indicated that proteomic analysis together with peptide identification is a good method for exploitation and utilization of spice plants.

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Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review

Koch,

Wawruszak,

Kukula-Koch

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Saffron anti-metastatic properties, ancient spice novel application

Cited by 13 publications

References 76 publications

Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms

Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms

Identification and Functional Validation of Two Novel Antioxidant Peptides in Saffron

Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review

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