Safety update on the possible causal relationship between gadolinium‐containing MRI agents and nephrogenic systemic fibrosis

Pedersen, Michael

doi:10.1002/jmri.20983

Cited by 35 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accordingly, tumor and lymph nodes are highlighted, and background signal is homogeneously suppressed. Since gadolinium-based contrast medium is not necessary in DWI imaging, this technique may be useful in patients with moderate to end-stage renal disease in order to prevent the development of nephrogenic systemic fibrosis (15,16). It is thus posited that DWI may improve the surgical and nonsurgical management of patients with cervical and uterine cancers in several ways.…”

Section: Figurementioning

confidence: 99%

Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T

Lin

Wang

et al. 2008

Magnetic Resonance Imaging

207

113

View full text Add to dashboard Cite

Purpose:To evaluate diffusion-weighted imaging (DWI) for detection of pelvic lymph node metastasis in patients with cervical and uterine cancers. Materials and Methods:Fifty patients scheduled for pelvic lymph node dissection were enrolled for 3T magnetic resonance imaging (MRI) using a single-shot echo-planar DWI technique, body-phased array coil, b ϭ 0, 1000 s/mm 2 . We measured short/long-axis diameters, mean apparent diffusion coefficient (ADC) values of all identifiable nodes, relative ADC values between tumors and nodes, and utilized their cutoff values to validate the diagnostic accuracy internally. Histopathologic results served as the reference standard. Results:The relative ADC values between tumor and nodes were significantly lower in metastatic than in benign nodes (0.06 vs. 0.21 ϫ 10 Ϫ3 mm 2 /s, P Ͻ 0.001; cutoff value 0.10 ϫ 10 Ϫ3 mm 2 /s). Compared to conventional MRI, the method combining size and relative ADC values resulted in better sensitivity (25% vs. 83%) and similar specificity (98% vs. 99%). The smallest metastatic lymph node detected by this method measured 5 mm on its short axis. Conclusion:The combination of size and relative ADC values was useful in detecting pelvic lymph node metastasis in patients with cervical and uterine cancers.

show abstract

Section: Figurementioning

confidence: 99%

Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T

Lin

Wang

et al. 2008

Magnetic Resonance Imaging

207

113

View full text Add to dashboard Cite

show abstract

“…Although generally believed to be nontoxic, a possible relationship between the administration of gadolinium-containing MR contrast agents, especially gadodiamide, and the development of nephrogenic fibrosing dermopathy (NFD) and nephrogenic systemic fibrosis (NSF) in patients with renal disease, was first reported in early 2006 (28,29). Anyway, this limits only the application of gadolinium-containing MR contrast agents to patients with severe renal failure and the causality is still not proven (30).…”

Section: Discussionmentioning

confidence: 96%

In vitro characterization of phosphatidylglyceroglycerol‐based thermosensitive liposomes with encapsulated ¹H MR T₁‐shortening gadodiamide

Wang¹,

Hossann²,

Reinl³

et al. 2008

Contrast Media & Molecular

View full text Add to dashboard Cite

Thermosensitive liposomes (TSL) with encapsulated proton (1H) magnetic resonance (MR) contrast agents have been proposed for noninvasive online temperature monitoring during tumor treatment using chemotherapy combined with hyperthermia (HT). The technique exploits the fact that water exchange between the TSL interior and exterior is increased and/or the encapsulated 1H MR contrast agent is released near the gel-to-liquid crystalline phase transition temperature (Tm) of TSL and thus shortens the 1H MR relaxation time of tissue. In this work, newly developed, phosphatidylglyceroglycerol (DPPGOG)-based TSL with encapsulated 1H MR longitudinal relaxation time (T1)-shortening gadodiamide (Gd-DTPA-BMA) were characterized in vitro by measuring the temperature dependence of the T1 of these gadodiamide-containing DPPGOG-TSL samples between 30 and 50 degrees C. The measurements revealed that the T1 nonlinearly slightly decreased with increasing temperature from 30 to 37 degrees C, mainly due to increased water exchange between the gadodiamide-containing DPPGOG-TSL interior and exterior with the exception of negligible gadodiamide release. This implies that gadodiamide-containing DPPGOG-TSL were stable at temperatures < or =37 degrees C, which was also confirmed by an independent stability study. From 37 to 44 degrees C, the T1 nonlinearly markedly decreased with increasing temperature since encapsulated gadodiamide was rapidly released. Above 44 degrees C, gadodiamide was completely released and the T1 was directly proportional to temperature while heated from 44 to 50 degrees C and cooled from 50 to 30 degrees C, respectively. Additionally, gadodiamide release was theoretically quantified and this calculated concentration was consistent with the actually released amount directly obtained from the cooling course of empty DPPGOG-TSL with completely released gadodiamide.

show abstract

“…The dermal fibrotic lesions may be the consequence of released Gd ions forming hydroxide and phosphate complexes then engulfed by the phagocytic system and activating a fibrous reaction with involvement of dendritic cells, TGF-beta synthesis, attraction of fibrocytes and precipitating the fibrotic cascade as occurs in the wound healing process. The bone marrow-derived circulating fibrocytes seem responsible for the systemic dermal sclerosis namely in uremic milieu in which many profibrogenic factors, such as erythropoietin therapy, hyperparathyroidism and metabolic acidosis, may play an important role in promoting the systemic inflammation [11,12,13]. The linkage between Gd infusion in ESRD and HD patients and NSF occurrence is still unexplained.…”

Section: Toxicity Of Gadolinium and Lanthanum-based Drugsmentioning

confidence: 95%

Gadolinium and lanthanum: A iatrogenic transmetallation?

Brambilla

Valaperta

Graziani

et al. 2008

Clinical Biochemistry

View full text Add to dashboard Cite

Safety update on the possible causal relationship between gadolinium‐containing MRI agents and nephrogenic systemic fibrosis

Cited by 35 publications

References 23 publications

Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T

Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T

In vitro characterization of phosphatidylglyceroglycerol‐based thermosensitive liposomes with encapsulated ¹H MR T₁‐shortening gadodiamide

Gadolinium and lanthanum: A iatrogenic transmetallation?

Contact Info

Product

Resources

About

Safety update on the possible causal relationship between gadolinium‐containing MRI agents and nephrogenic systemic fibrosis

Cited by 35 publications

References 23 publications

Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T

Detection of lymph node metastasis in cervical and uterine cancers by diffusion‐weighted magnetic resonance imaging at 3T

In vitro characterization of phosphatidylglyceroglycerol‐based thermosensitive liposomes with encapsulated 1H MR T1‐shortening gadodiamide

Gadolinium and lanthanum: A iatrogenic transmetallation?

Contact Info

Product

Resources

About

In vitro characterization of phosphatidylglyceroglycerol‐based thermosensitive liposomes with encapsulated ¹H MR T₁‐shortening gadodiamide