Safety tests of orgotein, an antiinflammatory protein

Carson, Steven; Vogin, Eugene E.; Huber, W.; Schulte, Tilman

doi:10.1016/0041-008x(73)90252-4

Cited by 48 publications

(8 citation statements)

References 9 publications

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“…In 1971 a positive identification was made between the enzyme isolated by McCord and Fridovich as superoxide dismutase (8) and a protein isolated several years earlier by Huber and co-workers on the basis of its anti-inflammatory properties (9). This anti-inflammatory protein had been named "orgotein."…”

Section: Introductionmentioning

confidence: 99%

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

Salin¹,

McCord²

1975

J. Clin. Invest.

266

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Section: Introductionmentioning

confidence: 99%

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

Salin¹,

McCord²

1975

J. Clin. Invest.

266

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“…There were no significant or serious side effects. Local allergic reaction has also been reported by others [31]. Previous studies [2;18] did not show any risk in using SOD for treatment of breast or bladder radiofibrosis.…”

Section: Discussionmentioning

confidence: 60%

“…In vitro and in vivo studies have demonstrated the radioprotective effect of the percutaneous administration of SOD (Cu/Zn) [31,32], but the results of controlled clinical studies are controversial concerning its efficacy as radioprotector [7,11,12,14].…”

Section: Discussionmentioning

confidence: 99%

Topical superoxide dismutase reduces post‐irradiation breast cancer fibrosis

Campana

Zervoudis

Perdereau

et al. 2004

J Cellular Molecular Medi

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Fibrosis following breast radiotherapy for mammary cancer is a frequent undesired effect with objective (esthetic) and subjective (pain) consequences. Forty‐four patients with clinical radiofibrosis following conservative treatment of breast cancer were evaluated for the local antifibrosis effect of copper zinc superoxide dismutase [SOD(Cu/Zn)]. Extracted SOD(Cu/Zn) in a concentration of 3,600 units/mg was applied as ointment to the fibrotic affected area, b.i.d. for 90 days, in a total dose of 40 mg. The radiofibrosis intensity was scored on the basis of clinical criteria (pain and the fibrosis area) before and after SOD(Cu/Zn) treatment. SOD(Cu/Zn) was found to be effective in reducing radiation induced fibrosis by a lowering pain score in 36/39 patients and a decrease of the fibrotic area size in half cases, after 6 months. The intensity and changes of breast fibrosis were assessed also by mammography and, for the topographical distribution of subcutaneous temperature, by infrared thermography. Mammography density suggested decreased fibrosis in one third of patients. Thermography showed that fibrosis was accompanied by two zones clinically indistinctive: a central area with maximum thermal activity, called “Maximal Thermic zone” (MTZ) and a peripheral area with less thermal activity but higher than in the surrounding normal tissue, “Transitional Thermic Zone” (TTZ). Both MTZ and TTZ were significantly decreased in 36/44 patients after SOD(Cu/Zn) treatment. Clinical changes persisted all along the study. Treatment was well tolerated except for one case of local allergic reaction, and no important side effects. Molecular mechanisms involved are discussed. Further studies are running to confirm and explain these results.

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“…In contrast, the safety of SOD (Orgotein) has been demonstrated by acute, subacute, and chronic toxicologic studies in various animal species including sensitization, reproduction, and teratologic studies (28,35). (Orgotein is the nonproprietary name for SOD assigned by the United States Adopted Names Council.…”

Section: Lungs Of Rats Exposedmentioning

confidence: 94%

Prevention of Hyperoxic-lnduced Depression of Pulmonary Serotonin Clearance by Pretreatment with Superoxide Dismutase^1–³

Block¹,

Fisher²

1977

Am Rev Respir Dis

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The therapeutic usefulness of 0 2 is limited primarily by pulmonary 0 2 toxicity, and there are no effective therapeutic modalities other than avoidance for prevention of this toxicity. In the present study, superoxide dismutase, an enzyme that catalyzes the dismutation of superoxide anion to less toxic forms, as well as reduced glutathione and succinate, two agents that protect against central nervous system 0 2 toxicity, were evaluated for ability to protect against the development of pulmonary 0 2 toxicity in the rat. Pulmonary 0 2 toxicity was evaluated by measuring lung clearance of serotonin in the isolated, perfused lung. Depression of serotonin clearance has recently been shown to be an index of early lung 0 2 poisoning. Rats received 60 nmole of superoxide dismutase per kg of body weight, 16 mmole of reduced glutathione per kg, 12 mmole of succinate per kg, or an equal volume of normal saline in a single intraperitoneal injection 45 min before a 60-min exposure to either 100 per cent 0 2 at 4 atm absolute or air. Lungs were then isolated, ventilated, and perfused using a recirculating system for measurement of serotonin clearance. Gross lung morphologic features, pulmonary arterial and ventilation pressures, and ratio of lung dry weight to wet weight were similar in all groups exposed to air and to 0 2 . The mean ±SE fractional clearance by the lungs of rats exposed to air was 0.79 ± 0.04 and did not vary with pretreatment. After exposure to 100 per cent 0 2 at 4 atm absolute, there was a 29 per cent decrease (0.56 ± 0.05; P < 0.001) in serotonin clearance. Pretreatment with reduced glutathione or succinate was not protective. In contrast, serotonin clearance by the lungs of rats exposed to 100 per cent 0 2 and treated with superoxide dismutase was 0.70 ± 0.04 (P < 0.02 versus 0 2 plus normal saline, reduced glutathione, or succinate; P>0.10 versus exposure to air). These results suggest that pretreatment of rats with superoxide dismutase may protect against the development of pulmonary 0 2 toxicity and that one mechanism of lung damage by hyperoxia may be increased biologic production of the superoxide anion.

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Safety tests of orgotein, an antiinflammatory protein

Cited by 48 publications

References 9 publications

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

Topical superoxide dismutase reduces post‐irradiation breast cancer fibrosis

Prevention of Hyperoxic-lnduced Depression of Pulmonary Serotonin Clearance by Pretreatment with Superoxide Dismutase^1–³

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Safety tests of orgotein, an antiinflammatory protein

Cited by 48 publications

References 9 publications

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

Topical superoxide dismutase reduces post‐irradiation breast cancer fibrosis

Prevention of Hyperoxic-lnduced Depression of Pulmonary Serotonin Clearance by Pretreatment with Superoxide Dismutase1–3

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Prevention of Hyperoxic-lnduced Depression of Pulmonary Serotonin Clearance by Pretreatment with Superoxide Dismutase^1–³