Safety survey by clinical pharmacists on COVID-19 vaccination from a single center in China

Wang, Guangfei; Zhu, Lin; Zhu, Yiqing; Ye, Qiaofeng; Yu, Xin; Fang, Meng; Lu, Jinmiao; Li, Xiaoxia; Huang, Yidie; Zhang, Junqi; Lan, Jianger; Zhai, Xiaowen; Xu, Hong; Li, Zhiping

doi:10.1080/21645515.2021.1913964

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…Thirty‐two studies 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 (23 observational studies 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ...…”

Section: Resultsunclassified

“…From the systematic review, we identified 300 articles 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ...…”

Section: Resultsunclassified

“…This observed prevalence is close to previous estimates from vaccines. 311 A wide range of prevalence rates across studies, ranging from 0.04% 33 to 25.4%, 39 have been previously reported. We conducted a subgroup analysis and found that vaccine platform and study design may influence the prevalence of cutaneous adverse reactions, as cutaneous adverse events are much more prevalent in mRNA platforms than in other platforms, and observational studies reported a greater number of cutaneous adverse events than randomized control trials.…”

Section: Discussionmentioning

confidence: 95%

“…From the systematic review, this report has described various cutaneous manifestations associated with the COVID‐19 vaccine including injection site reactions, 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 which were the most common cutaneous adverse reaction in almost all vaccines, uncommon adverse reactions such as delayed inflammatory reactions to tissue filler, 73 , 127 , 228 , 279 flares of pre‐existing dermatoses (e.g. psoriasis, 103 , 133 , 137 , 141 , 215 , 239 , 248 , 252 , 282 , 312 bullous pemphigoid, 63 , 111 pemphigus vulgaris, 111 , 121 lichen planus, 85 , …”

Section: Discussionmentioning

confidence: 99%

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Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID‐19 vaccination: A systematic review and meta‐analysis

Washrawirul

Triwatcharikorn

Phannajit

et al. 2022

Acad Dermatol Venereol

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Although vaccination is widely accepted as an effective method of preventing and controlling the COVID‐19 pandemic, many people are concerned about possible cutaneous side‐effects, which can delay or prevent them from being vaccinated. The objectives of this systematic review were to assess the global prevalence and clinical manifestations of cutaneous adverse reactions following COVID‐19 vaccination. PubMed and Scopus databases were searched for articles published from 1 January 2019 to 31 December 2021, and reference lists for each selected article were screened. Case reports, case series, observational studies and randomized controlled trials that provided information on cutaneous adverse reactions following COVID‐19 vaccines were included. A total of 300 studies were included in a systematic review of which 32 studies with 946 366 participants were included in the meta‐analysis. The pooled prevalence of cutaneous manifestations following COVID‐19 vaccination was 3.8% (95% CI, 2.7%–5.3%). COVID‐19 vaccines based on the mRNA platform had a higher prevalence than other platforms at 6.9% (95% CI, 3.8%–12.3%). Various cutaneous manifestations have been reported from injection site reactions, which were the most common (72.16%) to uncommon adverse reactions such as delayed inflammatory reactions to tissue filler (0.07%) and flares of pre‐existing dermatoses (0.07%). Severe cutaneous reactions such as anaphylaxis have also been reported, but in rare cases (0.05%). In conclusion, cutaneous adverse reactions are common, especially in those receiving mRNA vaccines. Most reactions are mild and are not contraindications to subsequent vaccination except for anaphylaxis, which rarely occurs. COVID‐19 vaccination may also be associated with flares of pre‐existing dermatoses and delayed inflammatory reactions to tissue filler. Patients with a history of allergies, pre‐existing skin conditions or scheduled for filler injections should receive additional precounselling and monitoring. A better understanding of potential side‐effects may strengthen public confidence in those wary of new vaccine technologies.

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Section: Resultsunclassified

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID‐19 vaccination: A systematic review and meta‐analysis

Washrawirul

Triwatcharikorn

Phannajit

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

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“…The majority of studies were cross‐sectional in design (22 studies), 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 followed by cohort (13 studies 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ) and case–control (one study 46 ) studies, respectively. Most of the studies were carried out in Europe (14 studies), followed by Eastern Asia (6 studies), Western Asia (5 studies), North America (4 studies), and South America (2 studies), respectively.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous adverse reactions following COVID‐19 vaccinations: A systematic review and meta‐analysis

Shafie’ei

Jamali

Akbari

et al. 2022

J of Cosmetic Dermatology

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Background COVID‐19 vaccines are currently the most effective interventions in controlling and preventing severe disease progression. Dermatologic reactions to COVID‐19 vaccinations may be rare among clinical trial participants. However, since global mass vaccination became a reality, these adverse effects may become more widespread, and different skin reactions would arise. Objective To systematically review the cutaneous adverse reactions in cases subject to vaccines for COVID‐19. Methods We searched the PubMed, SCOPUS, Web of Science, and Embase databases, identifying the relevant records and including the eligible observational ones. After assessing the methodological quality of the included studies, we qualitatively and quantitatively synthesized the data regarding the cutaneous side effects experienced by those in the studies' population. Results Overall, 36 studies were included in our systematic review, with the majority being cross‐sectional. We found that pain, erythema, and swelling were the most common local side effects, while different types of rashes, urticaria, and angioedema were the most non‐local. Few cases also reported experiencing flare‐ups of their underlying diseases or developing newly‐onset diseases of various etiologies. Our meta‐analyses also found that while viral vector‐based vaccines are, though insignificantly, safer in injection site complaints, individuals who received mRNA vaccines developed significantly fewer non‐local cutaneous adverse events. Discussion Cutaneous reactions to the COVID‐19 vaccines are similar to common cutaneous drug eruptions and COVID‐19 cutaneous manifestations. However, we believe that further high‐quality research is needed to assess better how and why cutaneous reactions occur in different vaccines.

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Self-Reported adverse events among Chinese healthcare workers immunized with COVID-19 vaccines composed of inactivated SARS-CoV-2

Cheng

Zheng

et al. 2022

Human Vaccines & Immunotherapeutics

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Safety survey by clinical pharmacists on COVID-19 vaccination from a single center in China

Cited by 9 publications

References 14 publications

Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID‐19 vaccination: A systematic review and meta‐analysis

Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID‐19 vaccination: A systematic review and meta‐analysis

Cutaneous adverse reactions following COVID‐19 vaccinations: A systematic review and meta‐analysis

Self-Reported adverse events among Chinese healthcare workers immunized with COVID-19 vaccines composed of inactivated SARS-CoV-2

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