Safety Results of a Multi-Institutional Phase 1 Clinical Trial of Afatinib in Combination with Docetaxel and Postoperative Radiation Therapy for High-Risk Squamous Cell Carcinoma of the Head and Neck
Abstract:patients received adjuvant CRT. On multivariable logistic regression, female sex, younger age, academic treatment facility, higher comorbidity index, and lower clinical T and N stages were associated with higher odds of receiving primary surgery. Three-year OS in the CRT cohort was 90.8% vs. 92.5% in patients receiving primary surgery (log-rank P Z .92). On multivariable Cox regression, upfront surgery was not associated with improved OS when compared with CRT (hazard ratio [HR] 1.10, 95% confidence interval [… Show more
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