Safety of Venous Thromboembolism Prophylaxis Protocol Using a Novel Leg Exercise Apparatus in Bedridden Patients due to Spinal Diseases

Kobayashi, K; Shimizu, Yoshiki; Haginoya, Ayumu; Hada, Yasushi; Yamazaki, Masashi

doi:10.7759/cureus.19136

Cited by 1 publication

(2 citation statements)

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“…Prevention by mechanical means has been proven to be effective in reducing the incidence of post‐traumatic VTE and does not increase the risk of bleeding complications 32 . Mechanical thrombosis prevention is beneficial for improving blood stasis and promoting blood reflux and is safer for spinal fractures at risk of bleeding 33 . Patients in the ICU are bedridden for long periods of time, with poor compliance and delayed recovery from ambulation.…”

Section: Discussionmentioning

confidence: 99%

“…32 Mechanical thrombosis prevention is beneficial for improving blood stasis and promoting blood reflux and is safer for spinal fractures at risk of bleeding. 33 Patients in the ICU are bedridden for long periods of time, with poor compliance and delayed recovery from ambulation. Also, patients with spinal fractures in the intensive care setting may have active bleeding from other sites and combined hemodynamic instability, so mechanical prophylaxis may be more convenient and appropriate.…”

Section: Discussionmentioning

confidence: 99%

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Venous thromboembolism prophylaxis and mortality in patients with spinal fractures in ICUs

Zhang

Yin

et al. 2023

Nursing in Critical Care

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BackgroundSpinal fracture is a common traumatic condition in orthopaedics, accounting for 5%–6% of total body fractures, and is a high‐risk factor for venous thromboembolism (VTE), which seriously affects patient prognosis.AimThe aim of this study was to determine the impact of VTE prophylaxis on the prognosis of patients with spinal fractures in intensive care units (ICUs) and to provide a scientific basis for clinical treatment and nursing.DesignA retrospective study of patients with spinal fractures from the multicenter eICU Collaborative Research Database.MethodThe outcomes of this study were ICU mortality and in‐hospital mortality. Patients were divided into the VTE prophylaxis (VP) and no VTE prophylaxis (NVP) groups according to whether they had undergone VTE prophylaxis during their ICU admission. The association between groups and outcomes were analysed using Kaplan–Meier (KM) survival curve, log‐rank test and the Cox proportional‐hazards regression model.ResultsThis study included 1146 patients with spinal fractures: 330 in the VP group and 816 in the NVP group. KM survival curves and log‐rank tests revealed that both ICU and in‐hospital survival probabilities in the VP group were significantly higher than in the NVP group. After the Cox model was adjusted for all covariates, the hazard ratio for ICU mortality in the VP group was 0.38 (0.19–0.75); the corresponding value for in‐hospital mortality in the VP group was 0.38 (0.21–0.68).ConclusionsVTE prophylaxis is associated with reduced ICU and in‐hospital mortality in patients with spinal fractures in ICUs. More research is necessary to further define specific strategies and optimal timing for VTE prophylaxis.Relevance to clinical practiceThis study provides the basis that VTE prophylaxis may be associated with improved prognosis in patients with spinal fractures in ICUs. In clinical practice, an appropriate modality should be selected for VTE prophylaxis in such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%