Safety of the nonionic contrast medium omnipaque in coronary angiography

Abstract

The low osmolar nonionic contrast medium Omnipaque was used in 5,339 consecutive coronary angiographies and serious complications were registered. Myocardial infarction occurred in 4 patients, of whom 2 died, and ventricular fibrillation in 1. Cerebral embolism occurred in 11 patients, all of whom survived. The results are compared with those of previous series of coronary angiography with high osmolar ionic media. It is concluded that use of the nonionic medium Omnipaque resulted in a significant reduction of the frequency of serious complications.

The Risk of Contrast Media-Induced Ventricular Fibrillation is Low in Canine Coronary Arteriography with Ioxilan.

“…So far, angialgia, peripheral vasodilation, hypervolemia, and cardiac hyposystole, which were suggested as being dependent on the hyperosmolality of ionic CM, have been almost eliminated by the use of newer low-osmolality nonionic CM [13]. Hyperosmolality of ionic CMs can also elevate the risk of VF [16], through the dehydration of cardiomyocytes which can inhibit the sinoatrial automaticity and atrioventricular conductivity [9,27], and/or reduce Purkinje fiber repolarization and conduction [9,15].…”

The importance of intraoperative angiographic findings for predicting long-term patency in coronary artery bypass operations

“…[61][62][63][64] The complication rate at our institution is low. [65][66][67][68] It is higher in older patients, patients with worse New York Heart Association (NYHA) functional class and multivessel involvement. [61][62][63] Factors such as low patient load 61,69 and prolongation of the procedure time 63,70 are associated with higher complication rates.…”

Characterization of ultrasound‐detected cerebral microemboli in patients undergoing cardiac catheterization using an in vitro middle cerebral artery model

“…The incidence of this complication has also been related to risk factors such as advanced age, smoking history, diabetes mellitus, hypertension, past strokes, cerebrovascular lesions, mild ventricular hypokinesia, and peripheral arterial disease [4,5,11]. However, in many patients, the exact cause of the complications is not precisely known [4], although cerebral atheromatous embolism [12][13][14][15][16][17], air embolism [18 -21], and high osmolar ionic contrast [1,6,22] have been implicated.…”