Safety of the Drug Prospekta: a Preclinical Study of Acute and Repeated Dose Toxicity

Kardash, E. V.; Bugaeva, L. I.; Lebedeva, S. A.; Sundukova, M. S.; Tarasov, S. A.

doi:10.1007/s10517-024-05990-8

Bull Exp Biol Med

2023

DOI: 10.1007/s10517-024-05990-8

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Safety of the Drug Prospekta: a Preclinical Study of Acute and Repeated Dose Toxicity

E. V. Kardash,

L. I. Bugaeva,

S. A. Lebedeva

et al.

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2024

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Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them

Don,

Zakharova,

Yaroshenko

et al. 2024

Dose-Response

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Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution’s activity. In the framework of this article, a statistically significant effect of TP antibodies to the insulin receptor on glucose consumption by CHO cells both with and without contact exposure, as compared with control ( P < 0.05) was shown in the vast majority of the experiments. The obtained results shed light on a possible source of activity of drugs based on TP antibodies, which should be associated with the applied vibration effect and can manifest itself both with contact exposure and without it.

show abstract

Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them

Don,

Zakharova,

Yaroshenko

et al. 2024

Dose-Response

View full text Add to dashboard Cite

show abstract

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Safety of the Drug Prospekta: a Preclinical Study of Acute and Repeated Dose Toxicity

Cited by 1 publication

References 3 publications

Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them

Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them

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