Safety of Subcutaneous Piperacillin/Tazobactam Administration Compared to Intravenous Administration: Propensity Score–Matched Cohort Study

Kobayashi, Daiki; Cho, Misuzu; Yokota, Kyoko; Shimbo, Takuro

doi:10.1016/j.jamda.2019.08.010

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…group. However, it also showed a notably higher all-cause mortality among patients receiving piperacillin/tazobactam via the s.c. route [26].…”

Section: Discussionmentioning

confidence: 99%

The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way

Leanza,

Liguoro,

Giuliano

et al. 2024

Infectious Disease Reports

View full text Add to dashboard Cite

The subcutaneous (s.c.) route is a commonly used method for delivering various drugs, although its application in the administration of antibiotics is relatively uncommon. In this case, we report a successful treatment of nosocomial pneumonia using piperacillin/tazobactam via continuous subcutaneous administration. Furthermore, this article provides an overview of the current literature regarding the s.c. administration of beta-lactam antibiotics. Based on our analysis, we identified only 15 studies that described the s.c. use of beta-lactam antibiotics in human subjects. Among these studies, cephalosporins were the most extensively investigated antibiotic class, with 10 available studies. According to the study findings, all three antibiotic classes (cephalosporins, penicillins, and carbapenems) demonstrated a similar pharmacokinetic profile when administered via the subcutaneous route. The subcutaneous route appears to be associated with a lower peak serum concentration (Cmax) but a comparable minimum blood concentration (Cmin) and an extended half-life (t1/2) when compared to conventional routes of antibiotic administration. Further research is necessary to determine whether subcutaneously administered beta-lactam antibiotics in human subjects achieve pharmacodynamic targets and demonstrate clinical efficacy.

show abstract

“…group. However, it also showed a notably higher all-cause mortality among patients receiving piperacillin/tazobactam via the s.c. route [26].…”

Section: Discussionmentioning

confidence: 99%

The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way

Leanza,

Liguoro,

Giuliano

et al. 2024

Infectious Disease Reports

View full text Add to dashboard Cite

show abstract

“…In a retrospective study of 368 patients (mean age, 87 years) hospitalized in an acute geriatric unit of a Spanish public hospital treated with SC antibiotics between January 2012 and December 2016, ceftriaxone (233/368) and ertapenem (98/368) were the most commonly prescribed SC antibiotics (13). Case series report the use of SC route for administrating piperacillin-tazobactam (14), ceftazidime (15)(16)(17), and fosfomycin (18).…”

Section: Main Antibioticsmentioning

confidence: 99%

Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections

et al. 2020

View full text Add to dashboard Cite

Since the 1970s, outpatient parenteral antimicrobial therapy (OPAT) has been a viable option for patients who require intravenous antibiotics when hospitalization is not warranted. While the benefits of OPAT as a measure to improve the efficiency of healthcare delivery (i.e., reduced hospital days) and patient satisfaction are well-documented, OPAT is associated with a number of challenges, including line complications and reliance on daily healthcare interactions in some cases at home or in a clinic. To minimize the continued need for intensive healthcare services in the outpatient setting, there is trend toward patients self-administering antibiotics at home without the presence of healthcare workers, after adequate training. In most cases, patients administer the antibiotics through an established intravenous catheter. While this OPAT practice is becoming more accepted as a standard of care, the potential for line complications still exists. Outpatient subcutaneous antimicrobial therapy (OSCAT) has become an increasingly accepted alternative route of administration of antibiotics to IV by French infectious diseases physicians and geriatricians; however, currently, no antibiotics are approved to be administered subcutaneously. Antibiotics with longer half-lives that are completely absorbed and have a favorable local tolerability profile are ideal candidates for OSCAT and have the potential to maximize the quality and efficiency of parenteral antibiotic delivery in the outpatient setting. The increasing development of wearable, on-body subcutaneous delivery systems make OSCAT even more viable as they increase patient independence while avoiding line complications and potentially removing the need for direct healthcare professional observation.

show abstract

Subcutaneous antibiotic therapy use by French general practitioners: Its interest and limitations

Forestier,

Janosch,

Vitrat

et al. 2023

Infectious Diseases Now

View full text Add to dashboard Cite

Safety of Subcutaneous Piperacillin/Tazobactam Administration Compared to Intravenous Administration: Propensity Score–Matched Cohort Study

Cited by 4 publications

References 7 publications

The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way

The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way

Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections

Subcutaneous antibiotic therapy use by French general practitioners: Its interest and limitations

Contact Info

Product

Resources

About