Safety of radiotherapy for hemodialysis patients with cancer

Hirota, H; Ito, Kei; Kageyama, Shun‐Ichiro; Tamamoto, Fumihiko; Kiura, Katsuyuki; Yoshimura, Ryouichi

doi:10.1007/s10147-020-01621-0

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…At present, no studies have compared radiation therapy with other treatment modalities in ESRD patients undergoing maintenance dialysis. Because the acute adverse effects caused by radiotherapy are frequently due to inflammation, radiotherapy-associated toxicities are expected to be worse in dialysis patients [35]. As a consequence, dialysis patients are also less likely to undergo radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…However, the lack of specific guidelines may deter oncologists from providing chemotherapy to dialysis patients. In addition to the difficulties in providing chemotherapy, little is known about the efficacy and prognosis of radiotherapy in dialysis patients [35]. At present, no studies have compared radiation therapy with other treatment modalities in ESRD patients undergoing maintenance dialysis.…”

Section: Discussionmentioning

confidence: 99%

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Stage at Diagnosis and Prognosis of Colorectal, Stomach, Lung, Liver, Kidney, and Bladder Cancers in Dialysis Patients: A Multicenter Retrospective Study Using Cancer Registry Data and Administrative Data

Kida

Morishima

Tsubakihara

et al. 2022

Nephron

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Background: Cancer is an important comorbidity that can affect survival in dialysis patients. However, it is unclear if dialysis patients who develop cancer are disadvantaged by later detection and poorer prognosis. This study comparatively examined the stage at diagnosis and prognosis of several common cancer types in dialysis and nondialysis patients. Methods: In this retrospective cohort study, cancer registry data were linked with administrative data to identify dialysis and nondialysis patients with any new diagnosis of cancer between 2010 and 2015 at 36 hospitals in Osaka Prefecture, Japan. In these patients, we identified the cancer stage at diagnosis for patients with colorectal, stomach, lung, liver, kidney, and bladder cancers. The association between dialysis and survival time (up to 3 years of follow-up) was examined for each cancer type using Cox proportional hazards models that adjusted for age, sex, and cancer stage. Results: We analyzed 2,161 dialysis patients and 158,964 nondialysis patients with cancer. Dialysis patients had a higher prevalence of colorectal, liver, and kidney cancers than nondialysis patients. Colorectal, stomach, lung, liver, and kidney cancers were diagnosed earlier in dialysis patients, whereas bladder cancer was diagnosed at an advanced stage. The Cox proportional hazards models revealed that mortality was significantly higher in dialysis patients with colorectal, stomach, lung, and bladder cancers than in nondialysis patients (all p < 0.05). Conclusions: Dialysis patients had higher mortality for several common cancers despite their earlier detection. This poorer prognosis may be influenced by the unavailability and complications of cancer treatment for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Stage at Diagnosis and Prognosis of Colorectal, Stomach, Lung, Liver, Kidney, and Bladder Cancers in Dialysis Patients: A Multicenter Retrospective Study Using Cancer Registry Data and Administrative Data

Kida

Morishima

Tsubakihara

et al. 2022

Nephron

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“…There have been a very few studies on RT for HD patients; for instance, a past study on RT for various primary sites in 56 HD patients revealed that both acute and late toxicities were clinically acceptable [14]. However, severe Grade 5 infections were recorded in four of these 56 patients.…”

Section: Discussionmentioning

confidence: 99%

“…RT is expected to be a promising treatment option for HD patients with cancer. However, there are limited reports on the safety of RT for HD patients [14]. Moreover, the safety of CIRT in HD patients remains to be ascertained.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Safety for Scanning Carbon-Ion Radiotherapy in Hemodialysis Patients With Prostate Cancer

Takakusagi

Suga

Kusano

et al. 2022

Cureus

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Background/AimThe efficacy and safety of carbon-ion radiotherapy (CIRT) for prostate cancer have already been demonstrated. The number of hemodialysis (HD) patients is increasing. Although the toxicity of CIRT in HD patients may be more severe, it has been insufficiently investigated. Therefore, we retrospectively analyzed the safety of CIRT for HD patients with prostate cancer in the present study. Materials and methodsFive HD patients with prostate cancer who underwent CIRT at the Kanagawa Cancer Center during November 2015-2020 were included in this study. CIRT was delivered by the raster scanning method (sCIRT). Adverse events were assessed using the Common Terminology Criteria for Adverse Events version 5.0. The dose-volume histogram (DVH) parameters of the target volume and normal organs were evaluated between initial planning computed tomography (CT) and in-room CT images. ResultsIn the acute phase, Grade 1 genitourinary toxicity was recorded in one patient. In the late phase, Grade 1 genitourinary toxicity was recorded in two patients. No gastrointestinal toxicities were noted during the follow-up period. In-room CT analysis revealed no significant differences among all DVH parameters of the target volume and normal organs when compared with the treatment plan dose. ConclusionsThe safety of sCIRT for prostate cancer in HD patients was investigated in the present study. In-room CT analysis suggested the robustness of the treatment plan. According to the present results, sCIRT for prostate cancer can be safely performed in HD patients.

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“…There have been a very few studies on RT for HD patients, for instance, a past study on RT for various primary sites in 56 HD patients revealed that both acute and late toxicities were clinically acceptable (14). However, severe Grade 5 infections were recorded in 4 of these 56 patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Safety for Scanning Carbon-Ion Radiotherapy in Hemodialysis Patients with Prostate Cancer

Takakusagi

Suga

Kusano

et al. 2021

Preprint

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Background/Aim The efficacy and safety of carbon-ion radiotherapy (CIRT) for prostate cancer have already been demonstrated. The number of hemodialysis (HD) patients is increasing. Although the toxicity of CIRT in HD patients may be more severe, it has been insufficiently investigated. Therefore, we retrospectively analyzed the safety of CIRT for HD patients with prostate cancer in the present study. Materials and Methods Five HD patients with prostate cancer who underwent CIRT at the Kanagawa Cancer Center during November 2015–2020 were included in this study. CIRT was delivered by the raster scanning method (sCIRT). Adverse events were assessed using the CTCAE v5.0. The dose-volume histogram (DVH) parameters of the target volume and normal organs were evaluated between initial planning computed tomography (CT) and in-room CT images. Results In the acute phase, Grade 1 genitourinary toxicity was recorded in 1 patient. In the late phase, Grade 1 genitourinary toxicity was recorded in 2 patients. No gastrointestinal toxicities were noted during the follow-up period. In-room CT analysis revealed no significant differences among all DVH parameters of the target volume and normal organs when compared with the treatment plan dose. Conclusions The safety of sCIRT for prostate cancer in HD patients was investigated in the present study. In-room CT analysis suggested the robustness of the treatment plan. According to the present results, sCIRT for prostate cancer can be safely performed in HD patients.

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Safety of radiotherapy for hemodialysis patients with cancer

Cited by 6 publications

References 24 publications

Stage at Diagnosis and Prognosis of Colorectal, Stomach, Lung, Liver, Kidney, and Bladder Cancers in Dialysis Patients: A Multicenter Retrospective Study Using Cancer Registry Data and Administrative Data

Stage at Diagnosis and Prognosis of Colorectal, Stomach, Lung, Liver, Kidney, and Bladder Cancers in Dialysis Patients: A Multicenter Retrospective Study Using Cancer Registry Data and Administrative Data

Evaluation of Safety for Scanning Carbon-Ion Radiotherapy in Hemodialysis Patients With Prostate Cancer

Evaluation of Safety for Scanning Carbon-Ion Radiotherapy in Hemodialysis Patients with Prostate Cancer

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