Safety of purified decolorized (low anthraquinone) whole leaf Aloe vera (L) Burm. f. juice in a 3-month drinking water toxicity study in F344 rats

Shao, Amy S.; Broadmeadow, A.; Goddard, G.; Béjar, Elsa; Frankos, Vasilios H.

doi:10.1016/j.fct.2013.03.002

Cited by 23 publications

(14 citation statements)

References 20 publications

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“…f. juice (total anthraquinones < 0.1 parts per million) was administered to F344/Du rats via drinking water at concentrations up to 2% (w/v). [25] This study was designed to compare the results obtained from other in vivo studies using whole leaf extract, specifically the NTP study reported by Boudreau and colleagues. [24] No significant toxicological findings were observed after subchronic exposure for 13 weeks.…”

Section: Aloe Vera Whole Leaf Extractmentioning

confidence: 99%

See 1 more Smart Citation

Aloe vera: A review of toxicity and adverse clinical effects

Guo

Mei

2016

Journal of Environmental Science and Health, Part C

198

135

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The Aloe plant is employed as a dietary supplement in a variety of foods and as an ingredient in cosmetic products. The widespread human exposure and its potential toxic and carcinogenic activities raise safety concerns. Chemical analysis reveals that the Aloe plant contains various polysaccharides and phenolic chemicals, notably anthraquinones. Ingestion of Aloe preparations is associated with diarrhea, hypokalemia, pseudomelanosis coli, kidney failure, as well as phototoxicity and hypersensitive reactions. Recently, Aloe vera whole leaf extract showed clear evidence of carcinogenic activity in rats, and was classified by the International Agency for Research on Cancer as a possible human carcinogen (Group 2B). This review presents updated information on the toxicological effects, including the cytotoxicity, genotoxicity, carcinogenicity, and adverse clinical effects of Aloe vera whole leaf extract, gel, and latex.

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Section: Aloe Vera Whole Leaf Extractmentioning

confidence: 99%

“…[26] These results suggest that anthraquinones may be a major contributor or serve as a marker of other agent(s) for Aloe vera-induced adverse effects. [25]…”

Section: Aloe Vera Whole Leaf Extractmentioning

confidence: 99%

Aloe vera: A review of toxicity and adverse clinical effects

Guo

Mei

2016

Journal of Environmental Science and Health, Part C

198

135

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“…Other important components of aloe vera consist of sugars (such as glucose, mannose, and cellulose) and enzymes (including oxidase, amylase and catalase, and folic acid), and minerals (such as calcium, sodium, magnesium, and zinc). This plant is mostly used in pharmaceuticals and cosmetic industries [16]. Prosopis plant is from Mimosaceae families which are common in many arid and semi-arid climates as trees and shrubs.…”

Section: Introductionmentioning

confidence: 99%

Phenol Removal from Aqueous Solution by Adsorption Process: Study of The Nanoparticles Performance Prepared from Alo vera and Mesquite (Prosopis) Leaves

et al. 2017

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Abstract. This study was performed to measure the potential utilization of agro-waste to generate nanoparticles and evaluate its capability as a low-cost adsorbent for phenol removal. Adsorption studies for phenol removal using aloe vera and mesquite leaves nanoparticles were carried out under various experimental conditions including pH, nanobioadsorbent dosage, phenol concentration, contact time, temperature, and ionic strength in a batch reactor. The adsorption kinetics were applied by pseudo-rst order and pseudosecond order models and isotherm technique by Freundlich and Langmuir isotherms models. The results showed that the rate of phenol adsorption increases in both nano-bioadsorbents with an increase in pH up to 7, adsorbent dosage up to 0.08 gL 1 , phenol initial concentration up to 32 mgL 1 , contact time up to 60 min, and a raise in temperature. The adsorption data followed the Freundlich isotherm model. The kinetic studies indicated that the adsorption of phenol with nano-bioadsorbents was best described by the pseudo-second order kinetics. We found that the nanoparticles prepared from aloe vera and mesquite leaves had a high capability in adsorption of phenol, besides the point that they could be accessed at low cost. These agro-wastes can be used to remove phenol from aqueous environments.

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“…[58] Purified decolorized (low anthraquinone) whole leaf A. vera (L.) Burm juice is toxic to rats. [59] Aloe ferox seed is a potential source of oil for cosmetic and pharmaceutical use, [60] while Aloe emodin, rhein, and emodin oral administration shows therapeutic effects in rats. [61] A. vera gel and extract are used in herboprobiotic therapy used for cardioprotection.…”

Section: Nutraceutical Usesmentioning

confidence: 99%

“…Oral administration of decolorized whole leaf A. vera extract impose adverse effects in rat colon. [59] Aloin inhibits angiogenesis and growth of human colorectal cancer in vitro and in vivo. [204] Whole leaf extract of A. barbadensis Miller (A. vera) shows anticarcinogenic activity in F344/N rats.…”

Section: Anticancer Activitymentioning

confidence: 99%

Untitled

Upadhyay¹

2018

IJGP

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The present review explains therapeutic and pharmaceutical potential of Aloe vera a well-known plant grows in semi-arid climate of tropical and subtropical regions. This article emphasizes important uses of A. vera constituents as dietary nutraceutical, medicinal, and therapeutic potential. Plant is cultivated for agricultural and medicinal and decoration purposes for indoors as a potted plant. Plant is a good depository of chemical constituents which display a very wide array of biological activities such as anticancer, antiparasitic, antidiabetic, anti-inflammatory, anti-arthritic, antiparasitic, antitumor, antioxidant, chemopreventive, hepatoprotective, and gastroprotective. Plant is used to prepare skin protective/care gels mainly for soothing, moisturizing, and wound healing. Thick watery plant sap works are added as key ingredient in many beauty products. Plant leaves are used to generate aroma, beverages, skin lotion, cosmetics, or ointments for minor burns. Plant contains vitamins, enzymes, minerals, sugars, lignin, saponins, salicylic acids, and amino acids as main ingredients. Plant is a good source of Vitamins A, C, and E, which are antioxidants. It also contains Vitamin B12, folic acid, and choline watery juicy of A. vera leaf which contains important minerals such as calcium, chromium, copper, selenium, magnesium, manganese, and potassium. Plant ingredients were found active against gingivitis, psoriasis, and used for herbal therapy in inflammatory bowel disease. A. vera contains important fatty acids mainly steroids such as cholesterol, campesterol, β-sitosterol, and lupeol. Aloin and emodin act as analgesics, antibacterials, and antivirals while lupeol shows antiseptic and analgesic properties. It also contains auxins and gibberellin hormones that help in wound healing and have anti-inflammatory action. Saponins that are the soapy substances display cleansing and antiseptic properties.

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Safety of purified decolorized (low anthraquinone) whole leaf Aloe vera (L) Burm. f. juice in a 3-month drinking water toxicity study in F344 rats

Cited by 23 publications

References 20 publications

Aloe vera: A review of toxicity and adverse clinical effects

Aloe vera: A review of toxicity and adverse clinical effects

Phenol Removal from Aqueous Solution by Adsorption Process: Study of The Nanoparticles Performance Prepared from Alo vera and Mesquite (Prosopis) Leaves

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