The study aimed to evaluate the risk of developing adverse drug reactions in patients aged 65 years and older who received drug treatment for mental disorders. The analysis demonstrated the potential of specific tools for assessing drug therapy appropriateness in a mental health setting. An assessment using «Trigger Tool for Measuring Adverse Drug Events in a Mental Health Setting» and «The GerontoNet ADR Risk Score» showed that more than half of hospitalized elderly patients are at risk of adverse reactions. In the majority of cases, this risk was associated with two major factors characterizing drug therapy in the study group: age and psychopharmacotherapy. These results highlight the importance of careful control over drug therapy safety in patients aged 65 years and older and therapy optimization when a high risk of adverse drug events is identified.