A 44-year-old man with cirrhosis is admitted with fever but has no obvious source of infection. His physical examination reveals ascites and minimal abdominal tenderness.
Why Is This Procedure Important?In a previous Rational Clinical Examination article, Williams and Simel 1 discussed the previous scenario and suggested performing a diagnostic paracentesis to seek for the source of the patient's fever. Ascites is the most common major complication of cirrhosis. 2 The syndrome of infected ascites was first recognized and described in the European literature in the early 20th century. [2][3][4] Infection occurs in as many as 27% of cirrhosis patients admitted to the hospital for evaluation and management of symptoms associated with ascites. The presentation of spontaneous bacterial peritonitis can range from silent to overt 5 ; however, patients typically have nonspecific symptoms such as nausea, abdominal pain, malaise, fever, or mild confusion. In reports 6 from the 1970s, the mortality rate from spontaneous bacterial peritonitis exceeded 90% but recent data 7 show a lower mortality rate of 30%. Diagnosis and subsequent treat-See also Patient Page. CME available online at www.jamaarchivescme.com and questions on p 1203.Context Abdominal paracenteses are performed in patients with ascites, most commonly to assess for infection or portal hypertension and to manage refractory ascites.Objectives To systematically review evidence for paracentesis methods that may decrease risk of adverse events or improve diagnostic yield and to determine the accuracy of ascitic fluid analysis for spontaneous bacterial peritonitis or portal hypertension.