Safety of outpatient percutaneous native renal biopsy in systemic autoimmune diseases: results from a monocentric cohort

Roccatello, Dario; Sciascia, Savino; Rossi, Daniela; Naretto, Carla; Bazzan, M.; Solfietti, Laura; M, Sandrone; Radin, Massimo; Baldovino, Simone; Menegatti, Elisa

doi:10.1177/0961203317751645

Cited by 7 publications

(4 citation statements)

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“…The data support that this procurement is feasible with high patient acceptance and that the rate of serious AE is comparable with published data for clinically obtained kidney biopsies. [17][18][19][20][21][22] Overall, 7.2% of the 475 patients with SLE experienced an AE attributable to the biopsy procedure, with an overall related serious AE rate of 3.8%. As expected, bleed-related complications, such as haematoma and haemoglobin decrease, were the most commonly reported complications, with less than 1% requiring a transfusion.…”

Section: Discussionmentioning

confidence: 99%

“…In large single-centre studies of kidney biopsies done for varying diseases, complication rates related to the procedure ranged from 14% to 17%, whereas studies of patients with autoimmune diseases (or specifically SLE) ranged from 4% to 11%. [17][18][19][20][21][22] A recent meta-analysis has shown that in all studies bleed-related complications were the AEs most commonly observed. 26 There are few studies that have extensively reported on the safety of a clinically indicated kidney biopsy specifically for suspected LN.…”

Section: Discussionmentioning

confidence: 99%

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Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

et al. 2021

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ObjectivesIn lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.ConclusionsProcurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

et al. 2021

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“…Therefore, renal biopsy is the gold standard for diagnosing nephropathy [1]. Ultrasound-guided percutaneous renal biopsy (renal puncture for short) is an important method for diagnosing renal parenchymal diseases, and it is of great significance for a precise diagnosis, guiding treatment and judging prognosis [1,2]. After a renal biopsy is performed to determine the pathological type, the specialist can make a reasonable treatment plan.…”

Section: Introductionmentioning

confidence: 99%

The effect of refined nursing education on improving the urination of patients after renal biopsy

Wang

Xie

et al. 2023

Ther Apher Dial

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BackgroundTo investigate the clinical effect of better nursing education on patients' postoperative urination after renal biopsy.MethodsIn this study, patients who underwent renal biopsy in the Department of Nephrology at our hospital were selected as the observation group (July–December 2018, n = 120) and control group (January–June 2018, n = 110) and received refined nursing education and routine nursing education, respectively. Postoperatively, the causes of dysuria after puncture, the degree of postoperative pain, and the urination mode were compared between the two groups.ResultsSix patients in the observation group and 23 patients in the control group needed urethral catheterization, accounting for about 5% and 15.2%, respectively. Therefore, the postoperative catheterization rate in the observation group was significantly lower than the control group, with a statistically significant difference.ConclusionThe refined nursing education proposed in this study can effectively improve urinary dysfunction after renal biopsy and has a clinical promotional value.

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“…The spectrum of glomerulopathies presenting as AKI varies depending on many factors, such as age, sex, race and geographical area, as well as biopsy policies [2,3].…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury associated with glomerular diseases

Fenoglio

Sciascia

Baldovino

et al. 2019

Current Opinion in Critical Care

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Safety of outpatient percutaneous native renal biopsy in systemic autoimmune diseases: results from a monocentric cohort

Cited by 7 publications

References 7 publications

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

The effect of refined nursing education on improving the urination of patients after renal biopsy

Acute kidney injury associated with glomerular diseases

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