Safety of ofloxacin — adverse drug reactions reported during phase-II studies in europe and in Japan

Blomer, R; Bruch, Kathrin; Krauss, Hanna; Wacheck, W

doi:10.1007/bf01661311

Cited by 33 publications

(14 citation statements)

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“…Mild eye disorders, such as corneal opacity, abnormal vision, retroocular pain, dizziness, lightheadedness, blurred vision, and photophobia, have been reported as ADRs of ciprofloxacin, enoxacin, pefloxacin, norfloxacin, and ofloxacin (Arcieri et al, 1989;Blomer et al, 1986;Chysky et al, 1991;Corraddo et al, 1987;Halkin, 1988;Sawada et al, 1991;Schacht et al, 1988;Young, 1985). The incidence of these symptoms, however, was very low, and no serious ophthalmic toxicity has been reported (Rapp et al, 1990).…”

Section: Phototoxicitymentioning

confidence: 97%

Toxicity of quinolone antimicrobial agents

Takayama¹,

Hirohashi²,

Kato³

et al. 1995

Journal of Toxicology and Environmental Health

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An approach to minimization of toxicity of a new compound is to elucidate the mechanisms of toxicity of analogous compounds and to clarify their structure-toxicity relationships. A problem with this approach, however, is that such elucidation remains difficult. For quinolones, some improvements in this mechanistic approach have been achieved in the central nervous system (CNS), particularly with regard to their interaction with non-steroidal anti-inflammatory drugs (NSAIDs), and in genotoxicity and phototoxicity studies, particularly in comparison with other toxicities, such as to the cardiovascular, gastrointestinal, bone, reproductive, and developmental systems. This review concentrates on a description of the known effects of quinolones on various organ systems in experimental animals and humans. Given the logarithmic increase in the synthesis of new quinolones, it is questionable whether these drugs share similar safety and efficacy. Nevertheless, this mechanistic approach to the investigation and minimization of toxicity has produced satisfactory results to date and deserves to be continued.

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Section: Phototoxicitymentioning

confidence: 97%

Toxicity of quinolone antimicrobial agents

Takayama¹,

Hirohashi²,

Kato³

et al. 1995

Journal of Toxicology and Environmental Health

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“…Rarely, hives or angioedema have been reported (3,4,20 Drug-Drug Interactions. Adverse interactions of quinolones with other drugs include those with theophylline and, possibly, non-steroidal anti-inflammatory drugs already discussed.…”

Section: Adverse Effectsmentioning

confidence: 98%

“…No bone toxicities were identified in either group. In adults receiving quinolones, arthritis, arthralgia and tenosynovitis have been uncommon and reversible adverse effects (1,3,5,20,(45)(46)(47)(48). For norfloxacin, four cases of reversible joint swelling and tendonitis have been reported, with recurrence occurring in two patients upon rechallenge (45, 49).…”

Section: Adverse Effectsmentioning

confidence: 99%

Quinolone antimicrobial agents: Adverse effects and bacterial resistance

1989

Eur. J. Clin. Microbiol. Infect. Dis.

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Adverse effects, drug-drug interactions and bacterial resistance to the new quinolone antimicrobial agents are reviewed. Clinical adverse effects are reported to occur in 5-10% of patients, and include primarily gastrointestinal disturbances, central nervous system toxicity and rash. Laboratory abnormalities are reported to occur in 5-12% of patients, and include mild reversible elevations of transaminases. Quinolones are not recommended in persons whose bone growth is incomplete or in pregnant or nursing women because cartilage toxicity has been observed in juvenile beagles. Drug-drug interactions may occur between quinolones and theophylline, caffeine, and magnesium- or aluminium-containing compounds such as antacids and sucralfate. Bacterial resistance occurs by chromosomal mutations which alter the target enzyme DNA gyrase or decrease drug accumulation. Emergence of resistance during therapy is uncommon to date but can be problematic in infections with Pseudomonas aeruginosa. Staphylococcus aureus and other bacteria for which the therapeutic index may be low. In summary, quinolones thus far have been well tolerated, but more experience is needed to determine the exact nature and extent of adverse effects and emergence of bacterial resistance.

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“…Fluorhinolonski antibitik, levofloxacin ima izveštaje o izazivanju akutnog delirijuma [25]. Slični navodi postoje i kod olfoksacina [26].…”

Section: Antiinfektivni Lekoviunclassified

Delirium: Focus on the drugs

Mitrović¹,

Stojkov²,

Radonjić³

et al. 2015

Engrami

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UVODStanje delirijuma imalo tokom istorije mnogo izmena i opisa. Termin ,,akutno konfuzno stanje" je generalno prihvatljivo u skoro svim definicijama koje su vezane za delirijum. Organska etoiopatogeneza nastanka delirijuma je vezana za akutni nastanak i uticaj spoljašnjih faktora. Pored mnogih mogućih uzročnika delirijuma, uticaj lekova na njegov razvoj je poznat. Kratak sadržajDelirijum je kompleksna pojava sa širokom lepezom simptoma i znaka od strane centralnog nervnog sistema. Osnovna karakteristika delirijuma je pomućenje svesti. Češće se javlja kod starijih osoba na hospitalnom lečenju. Ključne karakteristike delirijumskih stanja je njihov brz i agresivan početak, uzročnici su dominantno egzogeni, sa jasno izmenjenim stanjem svesti i pažnje, prisustvom halucinacija uz najčešće izraženo pogrešno predstavljanje opažanja. Epidemiološki podaci jasno ukazuju da vulnerabilni deo populacije čine stariji hospitalizovani pacijenti, posebno oni koji su izloženi ortopedskim operacijama kuka ili operacijama na srcu. Ovaj deo populacije, shodno godinama, uobičajeno koristi različite medikamente, od kojih pojedini mogu imati potencijala za razvoj delirijuma. Različiti lekovi imaju različite potencijale za nastanak delirijumskog stanja, pa je zato bitno dobro poznavati one koji imaju jasno definisane i opisane delirijumske potencijale (antiholinergički lekovi, hipnotici, antidepresivi, analgetici). Poznavanje ovog potencijala može dati značajnu prednost lekaru prilikom donošenja odluke za primenu određene grupe lekova, posebno u hospitalnim uslovima, a takođe i u bržem prepoznavanju simptomatologije delirijumskih stanja kod pacijenata koji su tokom hospitalizacije ili posle hiruških intrevencija upali u delirijumsko stanje. Postojanje protokola za dijagnostikovanje delirijuma, kao i dobro obučenog zdravstvenog osoblja za prepoznavanje i lečenje delirijumskih stanja, je važan preduslov kako za efikasnu borbu protiv nastanka delirijuma, tako i za saniranje njegovih posledica.

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Safety of ofloxacin — adverse drug reactions reported during phase-II studies in europe and in Japan

Cited by 33 publications

References 0 publications

Toxicity of quinolone antimicrobial agents

Toxicity of quinolone antimicrobial agents

Quinolone antimicrobial agents: Adverse effects and bacterial resistance

Delirium: Focus on the drugs

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