Safety of low‐dose oral minoxidil treatment for hair loss. A systematic review and pooled‐analysis of individual patient data

­Jimenez‐Cauhe, Juan; Saceda‐Corralo, David; Rodrigues‐Barata, Rita; Arrones, Oscar Muñoz-Moreno-; ­Ortega‐Quijano, ­Daniel; Fernández‐Nieto, Diego; Jaén‐Olasolo, Pedro; Vañó‐Galván, Sergio

doi:10.1111/dth.14106

Cited by 32 publications

(46 citation statements)

References 18 publications

(71 reference statements)

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“…Topical minoxidil (TM) and finasteride are the only approved treatment for male androgenetic alopecia, while for women only TM is approved. Nowadays, it is used widely in different hair disorders including scarring alopecias 4 . For a long time, minoxidil has been utilized as 2% or 5% topical solution; later, 5% foam was also commercialized 5 …”

Section: Introductionmentioning

confidence: 99%

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Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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Topical minoxidil has been used for many years as treatment for different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cosmesis, cost and side‐effects. During the last few years, low‐dose oral minoxidil has proven to be an alternative for patients with alopecia. We performed a literature search including all the articles that used oral minoxidil as a primary treatment in various hair diseases in order to evaluate the efficacy and safety of low‐dose oral minoxidil as an alternative to topical minoxidil. Androgenetic alopecia was the most common studied condition, but others included telogen effluvium, tractional alopecia, postchemotherapy‐induced alopecia, monilethrix, loose anagen hair syndrome, alopecia areata and scarring alopecias (frontal fibrosing alopecia and lichen planopilaris). Larger randomized comparative studies including standardized objective measurements should be done in order to clarify the best treatment protocol, including dosage and treatment duration. Oral minoxidil has proven to be a successful and well‐tolerated alternative for patients with hair loss, including those with poor adherence to other therapies. Different dosing regimens have been utilized in scarring and non‐scarring alopecia, varying from 0.25 to 5 mg daily. Higher doses have not been studied in men or women. Available literature suggests women require lower doses, from 0.25 to 2.5 mg daily, while men require higher doses for maximal efficacy, from 1.25 to 5 mg a day.

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Section: Introductionmentioning

confidence: 99%

“…Nowadays, it is used widely in different hair disorders including scarring alopecias. 4 For a long time, minoxidil has been utilized as 2% or 5% topical solution; later, 5% foam was also commercialized. 5 The exact mechanism of action is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Villani

Fabbrocini

Candiani³

et al. 2021

Acad Dermatol Venereol

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“…The side effects include salt and moisture retention; swelling; tachycardia; local peeling; dermatitis; skin irritation such as soreness; erythema; peeling at the site of administration [35]; itching; and dry skin due to a small amount of drug absorbed by the skin. Diffuse facial, forearm, cheek and neck hypertrichosis, redness, and contact dermatitis have been reported, and hirsutism can be induced in 0.5-1% of the users [36].…”

Section: Resultsmentioning

confidence: 99%

Regulation of Cytokines and Dihydrotestosterone Production in Human Hair Follicle Papilla Cells by Supercritical Extraction-Residues Extract of Ulmus davidiana

2022

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This study was conducted to examine the anti-hair loss mechanism of the supercritical fluid extraction-residues extract of Ulmus davidiana by the regulation of cytokine production and hormone function in human dermal follicle papilla cells (HDFPCs). To investigate the modulatory effects on H2O2-induced cytokines, we measured transforming growth factor-beta and insulin-like growth factor 1 secreted from HDFPCs. To investigate the regulatory effects of supercritical extraction-residues extract of Ulmus davidiana on dihydrotestosterone hormone production, cells were co-incubated with high concentrations of testosterone. The supercritical extraction-residues extract of Ulmus davidiana significantly inhibited the secretion of transforming growth factor-beta but rescued insulin-like growth factor 1 in a dose-dependent manner. The supercritical extraction-residues extract of Ulmus davidiana markedly reduced dihydrotestosterone production. These results suggest that the supercritical fluid extract residues of Ulmus davidiana and their functional molecules are candidates for preventing human hair loss.

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“…Moreover, minoxidil has side effects, including cardiovascular side effects in children who use minoxidil and irritative dermatitis. And diffuse facial, forearm, cheek and neck hypertrichosis, redness, and contact dermatitis have been reported, and hirsutism can be induced in 0.5%–1% of the users ( Hagemann et al, 2005 ; Georgala et al, 2006 ; Jimenez-Cauhe et al, 2020 ). Moreover, there is the disadvantage that hair returns to the state before treatment when minoxidil treatment is stopped ( do Nascimento et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion

Park

Gong

et al. 2022

Front. Bioeng. Biotechnol.

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Flavonoid aglycones possess biological activities, such as antioxidant and antidiabetic activities compared to glycosides. Taxifolin, a flavonoid aglycones, is detected only in trace amounts in nature and is not easily observed. Therefore, in this study, to investigate the hair tonic and hair loss inhibitors effect of taxifolin, high content of taxifolin aglycone extract was prepared by enzymatic hydrolysis. Taxifolin effectively regulates the apoptosis of dermal papilla cells, which is associated with hair loss, based on its strong antioxidant activities. However, inhibition of dihydrotestosterone (DHT), which is a major cause of male pattern hair loss, was significantly reduced with taxifolin treatment compared with minoxidil, as a positive control. It was also confirmed that a representative factor for promoting hair growth, IGF-1, was significantly increased, and that TGF-β1, a representative biomarker for hair loss, was significantly reduced with taxifolin treatment. These results suggest that taxifolin from enzymatic hydrolysis of RM is a potential treatment for hair loss and a hair growth enhancer.

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Safety of low‐dose oral minoxidil treatment for hair loss. A systematic review and pooled‐analysis of individual patient data

Cited by 32 publications

References 18 publications

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Review of oral minoxidil as treatment of hair disorders: in search of the perfect dose

Regulation of Cytokines and Dihydrotestosterone Production in Human Hair Follicle Papilla Cells by Supercritical Extraction-Residues Extract of Ulmus davidiana

Effects of taxifolin from enzymatic hydrolysis of Rhododendron mucrotulatum on hair growth promotion

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