Safety of laser-generated shockwave treatment for bacterial biofilms in a cutaneous rodent model

Yao, William C.; Kuan, Edward C.; Grundfest, Warren S.; John, Maie A. St.

doi:10.1007/s10103-020-03171-3

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Our group has also explored the safety profile of LGS, and it would appear that it exerts minimal effects to the surrounding normal tissues. Based on in vivo studies using rat dorsal skin, no thermal or mechanical injury, nor inflammatory response, was seen following LGS treatment . Another implication of bacterial permeabilization to aid in antibiotic delivery is that LGS is unlikely to be efficacious as monotherapy for bacterial disruption, and rather will have a complementary role in the treatment of recalcitrant soft tissue infections.…”

Section: Discussionmentioning

confidence: 99%

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In‐depth analysis of antibacterial mechanisms of laser generated shockwave treatment

et al. 2018

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Taken together, LGS does not appear to have direct bacteriocidal properties, but rather by allowing for biofilm disruption and bacterial cell membrane permeabilization, both of which likely increase topical antibiotic delivery to pathogenic organisms. Insight into the mechanisms of LGS will allow for improved clinical applications and facilitate safe and effective translation of this technology. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies involving LGS have demonstrated efficacy of biofilm disruption grown on ex vivo pig skin , and that LGS appears to enhance topical antibiotic activity in vitro . From preliminary in vivo studies, LGS has been found to spare normal, uninfected surrounding tissues and operates through a nonthermal mechanism .…”

Section: Introductionmentioning

confidence: 99%