Safety of doxycycline and minocycline: A systematic review

Smith, Kelly; Leyden, James J.

doi:10.1016/j.clinthera.2005.09.005

Cited by 295 publications

(255 citation statements)

References 146 publications

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“…MMP9 mRNA expression in circulating or infiltrated neutrophils is neglectable. 15,16 The absence of an effect of doxycycline on aortic wall MMP9 mRNA expression suggests that treatment does not affect MMP9 expression in other cell types (eg, macrophages). Together, these observations may suggest that the reduction of MMP9 protein can be ascribed mainly to the disappearance of aortic wall neutrophils and that the effects of doxycycline therapy relate to an antiinflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

“…1 In vitro studies characterize doxycycline as a pleiotropic antiinflammatory and immunomodulatory agent. 7 However, the relevance of this well-tolerated compound 15 for modulat-ing inflammation in human disease in general and AAA in particular is unclear. In this prospective clinical trial, we systematically examined the effect of 3 pharmacologically relevant doses (low [50/d], regular [100 mg/d], or high [300 mg/d]) of doxycycline on MMP9 expression and inflammatory processes in the aneurysmal wall of patients scheduled for elective open aneurysm repair.…”

Section: Clinical Perspective P 2216mentioning

confidence: 99%

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Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm

et al. 2009

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Background-Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content in a clinical trial and found that doxycycline selectively reduces neutrophil-derived proteases. We thus hypothesized that doxycycline acts through an effect on vascular inflammation. Methods and Results-Sixty patients scheduled for elective open aneurysmal repair were randomly assigned to 2 weeks of low-, medium-, or high-dose doxycycline (50, 100, or 300 mg/d, respectively) or no medication (control group). Aortic wall samples were collected at the time of operation, and the effect of doxycycline treatment on vascular inflammation was evaluated. Independently of its dose, doxycycline treatment resulted in a profound but selective suppression of aortic wall inflammation as reflected by a selective 72% reduction of the aortic wall neutrophils and a 95% reduction of the aortic wall cytotoxic T-cell content (median values; PϽ0.00003). Evaluation of major inflammatory pathways suggested that doxycycline treatment specifically quenched AP-1 and C/EBP proinflammatory transcription pathways (PϽ0.0158, NS) and reduced vascular interleukin-6 (PϽ0.00115), interleukin-8 (PϽ0.00246, NS), interleukin-13 (PϽ0.0184, NS), and granulocyte colony-stimulating factor (PϽ0.031, NS) protein levels. Doxycycline was well tolerated; there were no adverse effects. Conclusions-A brief period of doxycycline treatment has a profound but selective effect on vascular inflammation and reduces aortic wall neutrophil and cytotoxic T-cell content. Results of this study are relevant for pharmaceutical stabilization of the abdominal aneurysm and possibly for other inflammatory conditions that involve neutrophils and/or cytotoxic T cells.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical Perspective P 2216mentioning

confidence: 99%

Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm

et al. 2009

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“…Although allergic reactions are rarely related to antibiotics, meats and fruit induced by antibiotic residues have been reported in the literature 1, 8. The occurrence of antibiotic toxic effects has negative consequences on the gastrointestinal tract, skin, central nervous system, and even accumulating in calcium‐rich organs such as bones and teeth 9, 10, 11. Food intolerance has described in gym subjects due to intake of meat derived from administration of animals‐fed tetracycline 12.…”

Section: Introductionmentioning

confidence: 99%

Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline

Cerbo

Palatucci

Rubino

et al. 2015

J Biochem & Molecular Tox

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Antibiotics are widely used in zoo technical and veterinary practices as feed supplementation to ensure wellness of farmed animals and livestock. Several evidences have been suggesting both the toxic role for tetracyclines, particularly for oxytetracycline (OTC). This potential toxicity appears of great relevance for human nutrition and for domestic animals. This study aimed to extend the evaluation of such toxicity. The biologic impact of the drug was assessed by evaluating the proinflammatory effect of OTC and their bone residues on cytokine secretion by in vitro human peripheral blood lymphocytes. Our results showed that both OTC and OTC‐bone residues significantly induced the T lymphocyte and non‐T cell secretion of interferon (IFN)‐γ, as cytokine involved in inflammatory responses in humans as well as in animals. These results may suggest a possible implication for new potential human and animal health risks depending on the entry of tetracyclines in the food‐processing chain.

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“…No clinical data are available for the potential use of tigecycline for the treatment of MDR-TB in humans. The most common side-effects of doxycycline are gastrointestinal problems and skin reactions [77]. In a study with healthy subjects, tigecycline had no serious side-effects except for nausea and vomiting, which were dose-related [54].…”

Section: Tetracyclinesmentioning

confidence: 99%

Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

Alsaad

Wilffert

Altena

et al. 2013

European Respiratory Journal

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Treatment of multidrug-resistant (MDR) tuberculosis (TB) is challenging because of the high toxicity of second-line drugs and the longer treatment duration than for drug-susceptible TB patients. In order to speed up novel treatment for MDR-TB, we suggest considering expanding the indications of already available drugs. Six drugs with antimicrobial activity (phenothiazine, metronidazole, doxycycline, disulfiram, tigecycline and co-trimoxazole) are not listed in the World Health Organization guidelines on MDR-TB treatment but could be potential candidates for evaluation against Mycobacterium tuberculosis.A systematic review was conducted to evaluate antituberculous activity of these drugs against M. tuberculosis. We searched PubMed, Google Scholar and Embase for English articles published up to December 31, 2012.We reviewed in vitro, in vivo and clinical antituberculous activity of these drugs in addition to pharmacokinetics and side-effects. Of the drugs effective against actively replicating M. tuberculosis, cotrimoxazole seems to be the most promising, because of its consistent pharmacokinetic profile, easy penetration into tissue and safety profile. For the dormant state of TB, thioridazine may play a potential role as an adjuvant for treatment of MDR-TB. A strategy consisting of pharmacokinetic/pharmacodynamic studies, dose finding and phase III studies is needed to explore the role of these drugs in MDR-TB treatment.@ERSpublications Six antimicrobial drugs are not listed in WHO guidelines on MDR-TB treatment but could offer potential for TB treatment

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Safety of doxycycline and minocycline: A systematic review

Cited by 295 publications

References 146 publications

Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm

Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm

Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline

Potential antimicrobial agents for the treatment of multidrug-resistant tuberculosis

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